Zobrazeno 1 - 10
of 139
pro vyhledávání: '"Chisa Shukunami"'
Autor:
Shinsei Yambe, Yuki Yoshimoto, Kazutaka Ikeda, Koichiro Maki, Aki Takimoto, Akihide Tokuyama, Shinnosuke Higuchi, Xinyi Yu, Kenta Uchibe, Shigenori Miura, Hitomi Watanabe, Tetsushi Sakuma, Takashi Yamamoto, Kotaro Tanimoto, Gen Kondoh, Masataka Kasahara, Toshihide Mizoguchi, Denitsa Docheva, Taiji Adachi, Chisa Shukunami
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 12 (2024)
Fibrocartilaginous entheses consist of tendons, unmineralized and mineralized fibrocartilage, and subchondral bone, each exhibiting varying stiffness. Here we examined the functional role of sclerostin, expressed in mature mineralized fibrochondrocyt
Externí odkaz:
https://doaj.org/article/427052bd41564fbcaaa067f05c89e21b
Autor:
Viviana Reyes Alcaraz, Girish Pattappa, Shigenori Miura, Peter Angele, Torsten Blunk, Maximilian Rudert, Yuji Hiraki, Chisa Shukunami, Denitsa Docheva
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 11, p 5839 (2024)
Articular cartilage is crucial for joint function but its avascularity limits intrinsic repair, leading to conditions like osteoarthritis (OA). Chondromodulin-I (Cnmd) has emerged as a key molecule in cartilage biology, with potential implications fo
Externí odkaz:
https://doaj.org/article/53fd6ff84f4748ab8554616831778c6a
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
In vitro models allow for the study of developmental processes outside of the embryo. To gain access to the cells mediating digit and joint development, we identified a unique property of undifferentiated mesenchyme isolated from the distal early aut
Externí odkaz:
https://doaj.org/article/c2b23199d6a34bc8a9cc2873afec880b
Autor:
Junki Kawakami, Satoshi Hisanaga, Yuki Yoshimoto, Tomoji Mashimo, Takehito Kaneko, Naoto Yoshimura, Masaki Shimada, Makoto Tateyama, Hideto Matsunaga, Yuto Shibata, Shuntaro Tanimura, Kosei Takata, Takahiro Arima, Kazuya Maeda, Yuko Fukuma, Masaru Uragami, Katsumasa Ideo, Kazuki Sugimoto, Ryuji Yonemitsu, Kozo Matsushita, Masaki Yugami, Yusuke Uehara, Takayuki Nakamura, Takuya Tokunaga, Tatsuki Karasugi, Takanao Sueyoshi, Chisa Shukunami, Nobukazu Okamoto, Tetsuro Masuda, Takeshi Miyamoto
Publikováno v:
PLoS ONE, Vol 18, Iss 11, p e0293944 (2023)
When ruptured, ligaments and tendons have limited self-repair capacity and rarely heal spontaneously. In the knee, the Anterior Cruciate Ligament (ACL) often ruptures during sports activities, causing functional impairment and requiring surgery using
Externí odkaz:
https://doaj.org/article/8e17a326e2b4440793e160479a3c504c
Autor:
Kiminori Yukata, Chisa Shukunami, Yoshito Matsui, Aki Takimoto, Tomohiro Goto, Mitsuhiko Takahashi, Atsushi Mihara, Tetsuya Seto, Takashi Sakai, Yuji Hiraki, Natsuo Yasui
Publikováno v:
PLoS ONE, Vol 18, Iss 2 (2023)
Chondromodulin (Cnmd) is a glycoprotein known to stimulate chondrocyte growth. We examined in this study the expression and functional role of Cnmd during distraction osteogenesis that is modulated by mechanical forces. The right tibiae of the mice w
Externí odkaz:
https://doaj.org/article/a043a9130ce0427fa1c173fc0ced48cb
Autor:
Takenori Omoto, Dilimulati Yimiti, Yohei Sanada, Minoru Toriyama, Chenyang Ding, Yuta Hayashi, Yasunari Ikuta, Tomoyuki Nakasa, Masakazu Ishikawa, Masayuki Sano, Minjung Lee, Takayuki Akimoto, Chisa Shukunami, Shigeru Miyaki, Nobuo Adachi
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Tendon is a fibrous connective tissue, that is, transmitting the forces that permit body movement. However, tendon/ligament biology is still not fully understood and especially, the role of miRNAs in tendon/ligament is sparse and uncharacterized in i
Externí odkaz:
https://doaj.org/article/af9fa7052f93483fa724fe98b65a079f
Autor:
Long Guo, Aritoshi Iida, Gandham SriLakshmi Bhavani, Kalpana Gowrishankar, Zheng Wang, Jing-yi Xue, Juan Wang, Noriko Miyake, Naomichi Matsumoto, Takanori Hasegawa, Yusuke Iizuka, Masashi Matsuda, Tomoki Nakashima, Masaki Takechi, Sachiko Iseki, Shinsei Yambe, Gen Nishimura, Haruhiko Koseki, Chisa Shukunami, Katta M. Girisha, Shiro Ikegawa
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Sclerosing bone disorder (SBD) includes a broad spectrum of monogenic diseases characterised by increased bone density. Here, the authors describe a previously unknown SBD in four families caused by mutations in TMEM53 and demonstrate the role this p
Externí odkaz:
https://doaj.org/article/39666f07f5524b20abbe44216deb698c
Autor:
Niklas Kroner-Weigl, Jin Chu, Maximilian Rudert, Volker Alt, Chisa Shukunami, Denitsa Docheva
Publikováno v:
Biomedicines, Vol 11, Iss 3, p 772 (2023)
Self-assembling three-dimensional organoids that do not rely on an exogenous scaffold but maintain their native cell-to-cell and cell-to-matrix interactions represent a promising model in the field of tendon tissue engineering. We have identified der
Externí odkaz:
https://doaj.org/article/50ec4cd03730492483f99e0d035db7a3
Autor:
Yuki Yoshimoto, Akiyoshi Uezumi, Madoka Ikemoto-Uezumi, Kaori Tanaka, Xinyi Yu, Tamaki Kurosawa, Shinsei Yambe, Kazumitsu Maehara, Yasuyuki Ohkawa, Yusuke Sotomaru, Chisa Shukunami
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
The musculoskeletal system is integrated by tendons that are characterized by the expression of scleraxis (Scx), a functionally important transcription factor. Here, we newly developed a tenocyte induction method using induced pluripotent stem cells
Externí odkaz:
https://doaj.org/article/1d3079a60d864623becd1ac8a7366eaf
Autor:
Katsumasa Ideo, Takuya Tokunaga, Chisa Shukunami, Aki Takimoto, Yuki Yoshimoto, Ryuji Yonemitsu, Tatsuki Karasugi, Hiroshi Mizuta, Yuji Hiraki, Takeshi Miyamoto
Publikováno v:
PLoS ONE, Vol 15, Iss 12, p e0242286 (2020)
A multipotent cell population co-expressing a basic-helix-loop-helix transcription factor scleraxis (Scx) and SRY-box 9 (Sox9) has been shown to contribute to the establishment of entheses (tendon attachment sites) during mouse embryonic development.
Externí odkaz:
https://doaj.org/article/71dd67dfc26943afb3f5a20815ac82be