Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Chirine Toufaily"'
Autor:
Kaleeckal G Harikumar, Peishen Zhao, Brian P Cary, Xiaomeng Xu, Aditya J Desai, Maoqing Dong, Jesse I Mobbs, Chirine Toufaily, Sebastian G B Furness, Arthur Christopoulos, Matthew J Belousoff, Denise Wootten, Patrick M Sexton, Laurence J Miller
Publikováno v:
PLoS Biology, Vol 22, Iss 7, p e3002673 (2024)
Development of optimal therapeutics for disease states that can be associated with increased membrane cholesterol requires better molecular understanding of lipid modulation of the drug target. Type 1 cholecystokinin receptor (CCK1R) agonist actions
Externí odkaz:
https://doaj.org/article/897ba52f46f9422aa4eba66be6e9d3a4
Autor:
Frederique Ruf-Zamojski, Zidong Zhang, Michel Zamojski, Gregory R. Smith, Natalia Mendelev, Hanqing Liu, German Nudelman, Mika Moriwaki, Hanna Pincas, Rosa Gomez Castanon, Venugopalan D. Nair, Nitish Seenarine, Mary Anne S. Amper, Xiang Zhou, Luisina Ongaro, Chirine Toufaily, Gauthier Schang, Joseph R. Nery, Anna Bartlett, Andrew Aldridge, Nimisha Jain, Gwen V. Childs, Olga G. Troyanskaya, Joseph R. Ecker, Judith L. Turgeon, Corrine K. Welt, Daniel J. Bernard, Stuart C. Sealfon
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-20 (2021)
The pituitary gland plays important roles in the regulation of key physiological functions. Here the authors provide a multiomics atlas including transcriptome, chromatin accessibility, and methylation status of over 70,000 single nuclei (sn) from mo
Externí odkaz:
https://doaj.org/article/c782850ef40d4c03ac0d69ac797d06d6
Autor:
Chirine Toufaily, Jérôme Fortin, Carlos AI Alonso, Evelyne Lapointe, Xiang Zhou, Yorgui Santiago-Andres, Yeu-Farn Lin, Yiming Cui, Ying Wang, Dominic Devost, Ferdinand Roelfsema, Frederik Steyn, Aylin C Hanyaloglu, Terence E Hébert, Tatiana Fiordelisio, Derek Boerboom, Daniel J Bernard
Publikováno v:
eLife, Vol 10 (2021)
Gonadotropin-releasing hormone (GnRH) is the primary neuropeptide controlling reproduction in vertebrates. GnRH stimulates follicle-stimulating hormone (FSH) and luteinizing hormone (LH) synthesis via a G-protein-coupled receptor, GnRHR, in the pitui
Externí odkaz:
https://doaj.org/article/67a8eb78b0ce46eab129601c15478f79
Publikováno v:
Viruses, Vol 3, Iss 11, Pp 2146-2159 (2011)
Human endogenous retroviruses (HERVs) represent approximately 8% of our genome. HERVs influence cellular gene expression and contribute to normal physiological processes such as cellular differentiation and morphogenesis. HERVs have also been associa
Externí odkaz:
https://doaj.org/article/6d4ca26b934844969a9f8f208cbd91d3
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0121468 (2015)
Syncytin-2 is encoded by the envelope gene of Endogenous Retrovirus-FRD (ERVFRD-1) and plays a critical role in fusion of placental trophoblasts leading to the formation of the multinucleated syncytiotrophoblast. Its expression is consequently regula
Externí odkaz:
https://doaj.org/article/0860b912dd9d4ea3b3489bb48952e3ba
Autor:
Carlos A I Alonso, Caroline D David, Chirine Toufaily, Ying Wang, Xiang Zhou, Luisina Ongaro, German Nudelman, Venugopalan D Nair, Frederique Ruf-Zamojski, Ulrich Boehm, Stuart C Sealfon, Daniel J Bernard
Publikováno v:
Endocrinology. 164
Follicle-stimulating hormone (FSH), a dimeric glycoprotein produced by pituitary gonadotrope cells, regulates spermatogenesis in males and ovarian follicle growth in females. Hypothalamic gonadotropin-releasing hormone (GnRH) stimulates FSHβ subunit
Autor:
Ferdinand Roelfsema, Chirine Toufaily, Philipp Wartenberg, Xiang Zhou, Daniel J. Bernard, Ulrich Boehm, Gauthier Schang, John P. Lydon
Publikováno v:
Journal of Endocrinology, 244(1), 111-122. BIOSCIENTIFICA LTD
The progesterone receptor (PR, encoded by Pgr) plays essential roles in reproduction. Female mice lacking the PR are infertile, due to the loss of the protein’s functions in the brain, ovary, and uterus. PR is also expressed in pituitary gonadotrop
Autor:
Dominic Devost, Ying Wang, Xiang Zhou, Carlos A. I. Alonso, Frederik J. Steyn, Yorgui Santiago-Andres, Ferdinand Roelfsema, Terence E. Hébert, Yeu-Farn Lin, Evelyn Lapointe, Yimming Cui, Derek Boerboom, Aylin C. Hanyaloglu, Jérôme Fortin, Daniel J. Bernard, Tatiana Fiordelisio, Chirine Toufaily
Gonadotropin-releasing hormone (GnRH) is the primary neuropeptide controlling reproduction in vertebrates. GnRH stimulates follicle-stimulating hormone (FSH) and luteinizing hormone (LH) synthesis via a G protein-coupled receptor, GnRHR, in the pitui
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3c3280f500213107f7a8650184ae736d
https://doi.org/10.1101/2021.09.13.460073
https://doi.org/10.1101/2021.09.13.460073
Autor:
George A Stamatiades, Chirine Toufaily, Han Kyeol Kim, Xiang Zhou, Iain R Thompson, Rona S Carroll, Min Chen, Lee S Weinstein, Stefan Offermanns, Ulrich Boehm, Daniel J Bernard, Ursula B Kaiser
Publikováno v:
Endocrinology
Gonadotropin-releasing hormone (GnRH) regulates gonadal function via its stimulatory effects on gonadotropin production by pituitary gonadotrope cells. GnRH is released from the hypothalamus in pulses and GnRH pulse frequency differentially regulates
Autor:
Cristina Montagna, Jidong Shan, Pranav Nair, Yinghui Song, Stuart C. Sealfon, Hanna Pincas, Pamela L. Mellon, Kevin Kelley, Yongchao Ge, Nika Hines, Judith L Turgeon, Frederique Ruf-Zamojski, Venugopalan D. Nair, Chirine Toufaily, Daniel J. Bernard
Publikováno v:
Ruf-Zamojski, Frederique; Ge, Yongchao; Pincas, Hanna; Shan, Jidong; Song, Yinghui; Hines, Nika; et al.(2019). Cytogenetic, Genomic, and Functional Characterization of Pituitary Gonadotrope Cell Lines.. Journal of the Endocrine Society, 3(5), 902-920. doi: 10.1210/js.2019-00064. UC Davis: Retrieved from: http://www.escholarship.org/uc/item/6637m3d2
Journal of the Endocrine Society, vol 3, iss 5
Journal of the Endocrine Society
Journal of the Endocrine Society, vol 3, iss 5
Journal of the Endocrine Society
LβT2 and αT3-1 are important, widely studied cell line models for the pituitary gonadotropes that were generated by targeted tumorigenesis in transgenic mice. LβT2 cells are more mature gonadotrope precursors than αT3-1 cells. Microsatellite auth