Zobrazeno 1 - 10 of 195 pro vyhledávání: '"Chiriano, G"'
1
Akademický článek
Compound K14 inhibits bacterial killing and protease activity in Dictyostelium discoideum phagosomes.
Autor: Ifrid E; Department of Cell Physiology and Metabolism, Faculty of Medicine, University of Geneva, Geneva, Switzerland., Ouertatani-Sakouhi H; Department of Cell Physiology and Metabolism, Faculty of Medicine, University of Geneva, Geneva, Switzerland., Zein El Dine H; Department of Cell Physiology and Metabolism, Faculty of Medicine, University of Geneva, Geneva, Switzerland., Jauslin T; Department of Cell Physiology and Metabolism, Faculty of Medicine, University of Geneva, Geneva, Switzerland., Chiriano G; Pharmaceutical biochemistry, School of pharmaceutical sciences, University of Geneva, Geneva, Switzerland., Scapozza L; Pharmaceutical biochemistry, School of pharmaceutical sciences, University of Geneva, Geneva, Switzerland., Lamrabet O; Department of Cell Physiology and Metabolism, Faculty of Medicine, University of Geneva, Geneva, Switzerland., Cosson P; Department of Cell Physiology and Metabolism, Faculty of Medicine, University of Geneva, Geneva, Switzerland.
Publikováno v: PloS one [PLoS One] 2024 Aug 26; Vol. 19 (8), pp. e0309327. Date of Electronic Publication: 2024 Aug 26 (Print Publication: 2024).
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2
Akademický článek
5-ethyl-2'-deoxyuridine fragilizes Klebsiella pneumoniae outer wall and facilitates intracellular killing by phagocytic cells.
Autor: Ifrid E; Department of Cell Physiology and Metabolism, Faculty of Medicine, University of Geneva, Centre Médical Universitaire, Geneva, Switzerland., Ouertatani-Sakouhi H; Department of Cell Physiology and Metabolism, Faculty of Medicine, University of Geneva, Centre Médical Universitaire, Geneva, Switzerland., Jauslin T; Department of Cell Physiology and Metabolism, Faculty of Medicine, University of Geneva, Centre Médical Universitaire, Geneva, Switzerland., Kicka S; Department of Biochemistry, Faculty of Science, University of Geneva, Geneva, Switzerland., Chiriano G; Pharmaceutical Biochemistry, School of Pharmaceutical Sciences, University of Geneva, Geneva, Switzerland., Harrison CF; Max von Pettenkofer Institute, Department of Medicine, Ludwig-Maximilians University Munich, Munich, Germany., Hilbi H; Institute of Medical Microbiology, Department of Medicine, University of Zürich, Zürich, Switzerland., Scapozza L; Pharmaceutical Biochemistry, School of Pharmaceutical Sciences, University of Geneva, Geneva, Switzerland., Soldati T; Department of Biochemistry, Faculty of Science, University of Geneva, Geneva, Switzerland., Cosson P; Department of Cell Physiology and Metabolism, Faculty of Medicine, University of Geneva, Centre Médical Universitaire, Geneva, Switzerland.
Publikováno v: PloS one [PLoS One] 2022 Oct 31; Vol. 17 (10), pp. e0269093. Date of Electronic Publication: 2022 Oct 31 (Print Publication: 2022).
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4
Sequential virtual screening approach to the identification of small organic molecules as potential BACE-1 inhibitors
Autor: Chiriano G., Sartini A., Carloni P., MANCINI, FRANCESCA, ANDRISANO, VINCENZA, BOLOGNESI, MARIA LAURA, ROBERTI, MARINELLA, RECANATINI, MAURIZIO, CAVALLI, ANDREA
Publikováno v: Chemical biologydrug design. 77(4)
In this letter, we report on the sequential application of two different in silico screening approaches combined with bioassays aimed at the identification of small organic molecules as potential BACE-1 inhibitors. Two hits endowed of micromolar inhi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::d9e6f5bbd353cead2b0715bc219c56f1
https://pubmed.ncbi.nlm.nih.gov/21244641
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5
Akademický článek
Identification of Anti- Mycobacterium and Anti- Legionella Compounds With Potential Distinctive Structural Scaffolds From an HD-PBL Using Phenotypic Screens in Amoebae Host Models.
Autor: Hanna N; Department of Biochemistry, Faculty of Sciences, University of Geneva, Geneva, Switzerland., Kicka S; Department of Biochemistry, Faculty of Sciences, University of Geneva, Geneva, Switzerland., Chiriano G; Pharmaceutical Biochemistry/Chemistry, School of Pharmaceutical Sciences, University of Geneva, Geneva, Switzerland., Harrison C; Max von Pettenkofer Institute, Ludwig Maximilian University of Munich, Munich, Germany., Sakouhi HO; Department of Cell Physiology and Metabolism, Faculty of Medicine, University of Geneva, Geneva, Switzerland., Trofimov V; Department of Biochemistry, Faculty of Sciences, University of Geneva, Geneva, Switzerland., Kranjc A; Pharmaceutical Biochemistry/Chemistry, School of Pharmaceutical Sciences, University of Geneva, Geneva, Switzerland., Nitschke J; Department of Biochemistry, Faculty of Sciences, University of Geneva, Geneva, Switzerland., Pagni M; Swiss Institute of Bioinformatics, Lausanne, Switzerland., Cosson P; Department of Cell Physiology and Metabolism, Faculty of Medicine, University of Geneva, Geneva, Switzerland., Hilbi H; Institute of Medical Microbiology, University of Zurich, Zurich, Switzerland., Scapozza L; Pharmaceutical Biochemistry/Chemistry, School of Pharmaceutical Sciences, University of Geneva, Geneva, Switzerland., Soldati T; Department of Biochemistry, Faculty of Sciences, University of Geneva, Geneva, Switzerland.
Publikováno v: Frontiers in microbiology [Front Microbiol] 2020 Feb 21; Vol. 11, pp. 266. Date of Electronic Publication: 2020 Feb 21 (Print Publication: 2020).
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7
Design of ligands with a high affinity to PrPC
Autor: Kranjc, A., Bongarzone, S., Chiriano, G., Rossetti, G., Biarnés, X., ANDREA CAVALLI, Maria Laura Bolognesi, MARINELLA ROBERTI, Legname, G., Carloni, P.
Publikováno v: Alma Mater Studiorum Università di Bologna-IRIS
Prion diseases, also known as transmissible spongiform encephalopathies (TSE), are fatal neurodegenerative disorders of the central nervous system. The main molecular mechanism underlining TSE is based on the aberrant misfolding of the cellular form
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::ba7b8fb2d6c2e1850dc912948fe4f96d
http://hdl.handle.net/20.500.11767/15549
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8
Akademický článek
Targeting RNA structure in SMN2 reverses spinal muscular atrophy molecular phenotypes.
Autor: Garcia-Lopez A; Pharmaceutical Biochemistry Group, School of Pharmaceutical Sciences, University of Lausanne and University of Geneva, Rue Michel-Servet 1, 1211, Geneva, Switzerland. amparo.garcialopez@unige.ch., Tessaro F; Pharmaceutical Biochemistry Group, School of Pharmaceutical Sciences, University of Lausanne and University of Geneva, Rue Michel-Servet 1, 1211, Geneva, Switzerland., Jonker HRA; Institut für Organische Chemie und Chemische Biologie, Center for Biomolecular Magnetic Resonance (BMRZ), Johann Wolfgang Goethe-University Frankfurt, Max-von-Laue-Strasse 7, 60438, Frankfurt, Germany., Wacker A; Institut für Organische Chemie und Chemische Biologie, Center for Biomolecular Magnetic Resonance (BMRZ), Johann Wolfgang Goethe-University Frankfurt, Max-von-Laue-Strasse 7, 60438, Frankfurt, Germany., Richter C; Institut für Organische Chemie und Chemische Biologie, Center for Biomolecular Magnetic Resonance (BMRZ), Johann Wolfgang Goethe-University Frankfurt, Max-von-Laue-Strasse 7, 60438, Frankfurt, Germany., Comte A; Institut de Chimie et Biochimie Moléculaires et Supramoléculaires (ICBMS), UMR CNRS 5246, University Claude Bernard Lyon 1, 43 Bd du 11 Novembre 1918, F-69622, Villeurbanne cedex, France., Berntenis N; Pharmaceutical Research and Early Development, F. Hoffmann-La Roche, Roche Innovation Center Basel, Grenzacherstrasse 124, 4070, Basel, Switzerland., Schmucki R; Pharmaceutical Research and Early Development, F. Hoffmann-La Roche, Roche Innovation Center Basel, Grenzacherstrasse 124, 4070, Basel, Switzerland., Hatje K; Pharmaceutical Research and Early Development, F. Hoffmann-La Roche, Roche Innovation Center Basel, Grenzacherstrasse 124, 4070, Basel, Switzerland., Petermann O; Pharmaceutical Biochemistry Group, School of Pharmaceutical Sciences, University of Lausanne and University of Geneva, Rue Michel-Servet 1, 1211, Geneva, Switzerland., Chiriano G; Pharmaceutical Biochemistry Group, School of Pharmaceutical Sciences, University of Lausanne and University of Geneva, Rue Michel-Servet 1, 1211, Geneva, Switzerland., Perozzo R; Pharmaceutical Biochemistry Group, School of Pharmaceutical Sciences, University of Lausanne and University of Geneva, Rue Michel-Servet 1, 1211, Geneva, Switzerland., Sciarra D; Pharmaceutical Biochemistry Group, School of Pharmaceutical Sciences, University of Lausanne and University of Geneva, Rue Michel-Servet 1, 1211, Geneva, Switzerland., Konieczny P; Translational Genomics Group, Incliva Health Research Institute, Menendez Pelayo 4, 46010, Valencia, Spain.; Department of Genetics and Interdisciplinary Research Structure for Biotechnology and Biomedicine (ERI BIOTECMED), University of Valencia, Dr Moliner 50, 46100, Burjassot, Spain., Faustino I; Institute for Research in Biomedicine (IRB), Barcelona Institute of Science and Technology (BIST), Joint BSC-IRB Research Program in Computational Biology, Baldiri Reixac 10, 08028, Barcelona, Spain., Fournet G; Institut de Chimie et Biochimie Moléculaires et Supramoléculaires (ICBMS), UMR CNRS 5246, University Claude Bernard Lyon 1, 43 Bd du 11 Novembre 1918, F-69622, Villeurbanne cedex, France., Orozco M; Institute for Research in Biomedicine (IRB), Barcelona Institute of Science and Technology (BIST), Joint BSC-IRB Research Program in Computational Biology, Baldiri Reixac 10, 08028, Barcelona, Spain., Artero R; Translational Genomics Group, Incliva Health Research Institute, Menendez Pelayo 4, 46010, Valencia, Spain.; Department of Genetics and Interdisciplinary Research Structure for Biotechnology and Biomedicine (ERI BIOTECMED), University of Valencia, Dr Moliner 50, 46100, Burjassot, Spain., Metzger F; Pharmaceutical Research and Early Development, F. Hoffmann-La Roche, Roche Innovation Center Basel, Grenzacherstrasse 124, 4070, Basel, Switzerland., Ebeling M; Pharmaceutical Research and Early Development, F. Hoffmann-La Roche, Roche Innovation Center Basel, Grenzacherstrasse 124, 4070, Basel, Switzerland., Goekjian P; Institut de Chimie et Biochimie Moléculaires et Supramoléculaires (ICBMS), UMR CNRS 5246, University Claude Bernard Lyon 1, 43 Bd du 11 Novembre 1918, F-69622, Villeurbanne cedex, France., Joseph B; Institut de Chimie et Biochimie Moléculaires et Supramoléculaires (ICBMS), UMR CNRS 5246, University Claude Bernard Lyon 1, 43 Bd du 11 Novembre 1918, F-69622, Villeurbanne cedex, France., Schwalbe H; Institut für Organische Chemie und Chemische Biologie, Center for Biomolecular Magnetic Resonance (BMRZ), Johann Wolfgang Goethe-University Frankfurt, Max-von-Laue-Strasse 7, 60438, Frankfurt, Germany., Scapozza L; Pharmaceutical Biochemistry Group, School of Pharmaceutical Sciences, University of Lausanne and University of Geneva, Rue Michel-Servet 1, 1211, Geneva, Switzerland. leonardo.scapozza@unige.ch.
Publikováno v: Nature communications [Nat Commun] 2018 May 23; Vol. 9 (1), pp. 2032. Date of Electronic Publication: 2018 May 23.
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9
Akademický článek
Inhibitors of Mycobacterium marinum virulence identified in a Dictyostelium discoideum host model.
Autor: Ouertatani-Sakouhi H; Faculty of Medicine, Department of Cell Physiology and Metabolism, University of Geneva, Geneva, Switzerland., Kicka S; Department of Biochemistry, University of Geneva, Geneva, Switzerland., Chiriano G; Pharmaceutical biochemistry, School of pharmaceutical sciences, University of Geneva, University of Lausanne, 30 Quai Ernst Ansermet, Geneva, Switzerland., Harrison CF; Max von Pettenkofer Institute, Department of Medicine, Ludwig-Maximilians University Munich, Munich, Germany., Hilbi H; Max von Pettenkofer Institute, Department of Medicine, Ludwig-Maximilians University Munich, Munich, Germany.; Institute of Medical Microbiology, Department of Medicine, University of Zürich, Gloriastrasse 30/32, Zürich, Switzerland., Scapozza L; Pharmaceutical biochemistry, School of pharmaceutical sciences, University of Geneva, University of Lausanne, 30 Quai Ernst Ansermet, Geneva, Switzerland., Soldati T; Department of Biochemistry, University of Geneva, Geneva, Switzerland., Cosson P; Faculty of Medicine, Department of Cell Physiology and Metabolism, University of Geneva, Geneva, Switzerland.
Publikováno v: PloS one [PLoS One] 2017 Jul 20; Vol. 12 (7), pp. e0181121. Date of Electronic Publication: 2017 Jul 20 (Print Publication: 2017).
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10
Akademický článek
The Involvement of Reactive Oxygen Species in Causing Chronic Cardiovascular and Neurodegenerative Diseases and Some Cancers.
Autor: Tiwana, Jasneet K.1, Shah, Anureet K.2, Dhalla, Naranjan S.1 nsdhalla@sbrc.ca
Publikováno v: Scripta Medica. Mar/Apr2024, Vol. 55 Issue 2, p199-217. 19p.
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