Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Chirgwin John Mitchell"'
Publikováno v:
Biochemistry. 20:1756-1761
A new covalent active site reagent, 1-chloro-2-oxo-6-hexanol 6-phosphate, has been synthesized from glutaric acid monomethyl ester and characterized by NMR spectroscopy. Inactivation of phosphoglucose isomerase, when incubated with various modifier c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e26740077c270f2cbbc8d30c69449df3
https://doi.org/10.1021/bi00510a008
https://doi.org/10.1021/bi00510a008
Autor:
Nina Piccini, Peter Rotwein, Chirgwin John Mitchell, Ida M. Schaefer, S. L. Naylor, Kenneth W. Gross
Publikováno v:
Somatic Cell and Molecular Genetics. 10:415-421
DNA sequences encoding kidney renin were localized to region p21----qter of human chromosome 1 by Southern blot analysis of mouse-human somatic cell hybrids with a cloned human renin DNA probe. The renin gene may be a member of a chromosome 1 linkage
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1dd9b44700dafb9b3a6b00219deb1dbf
https://doi.org/10.1007/bf01535637
https://doi.org/10.1007/bf01535637
Autor:
Edmund Tischer, Axel Ullrich, Howard M. Goodman, Chirgwin John Mitchell, John Shine, William J. Rutter, Raymond Pictet
Publikováno v:
Science. 196:1313-1319
Recombinant bacterial plasmids have been constructed that contain complementary DNA prepared from rat islets of Langerhans messenger RNA. Three plasmids contain cloned sequences representing the complete coding region of rat proinsulin I, part of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e022281b1199c323de0e156b8de21458
https://doi.org/10.1126/science.325648
https://doi.org/10.1126/science.325648
Publikováno v:
The Journal of Cell Biology
Renin is an aspartyl protease which is highly homologous to the lysosomal aspartyl protease cathepsin D. During its biosynthesis, cathepsin D acquires phosphomannosyl residues that enable it to bind to the mannose 6-phosphate (Man-6-P) receptor and t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a5f19388c57659048ce1932200460ce
http://europepmc.org/articles/PMC2114873
http://europepmc.org/articles/PMC2114873
Publikováno v:
Diabetes Care. 7:386-394
This review focuses on recent advances in molecular biology as they pertain to the insulin gene and diabetes mellitus. The structure of the human insulin gene is examined, andfactors related to its normal functioning in the beta cells of the pancreas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6b123e018221d100c19c5ba4a2e9ea7
https://doi.org/10.2337/diacare.7.4.386
https://doi.org/10.2337/diacare.7.4.386
Autor:
Chirgwin John Mitchell, Jasjit S. Bindra, Beryl W. Dominy, Peter M. Hobart, B. L. Sibanda, Tom L. Blundell, Michael Fogliano
Publikováno v:
FEBS Letters. 174:102-111
A model has been constructed using computer graphics for human renin based on the sequence derived from that of the gene and the 3-dimensional structure defined at high resolution for other homologous aspartic proteinases. Human renin can adopt a 3-d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bea27f521be4fe4dfd43c41c5ef12e39
https://doi.org/10.1016/0014-5793(84)81086-8
https://doi.org/10.1016/0014-5793(84)81086-8
Publikováno v:
Diabetes. 31:624-629
The purpose of these studies was to determine whether glucose, the principal regulator of insulin biosynthesis in mammals, controls synthesis through alterations in levels of proinsulin mRNA in whole animals. Rats were starved for 3 days and then eit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cd871214d31da650fbd69e8625cb271
https://doi.org/10.2337/diab.31.7.624
https://doi.org/10.2337/diab.31.7.624
Autor:
Raymond J. MacDonald, Alan Przybyla, Raymond Pictet, J. D. Harding, Chirgwin John Mitchell, William J. Rutter
Publikováno v:
Journal of Biological Chemistry. 252:7391-7397
The sequence complexity and frequency distribution of adult rat pancreas polyadenylated RNAs and the changes in these pancreas transcripts during development have been analyzed by means of complementary DNA-RNA hybridization analysis. The following r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f4f63d047322f9df3ac0efdc7d4993d4
https://doi.org/10.1016/s0021-9258(19)66977-2
https://doi.org/10.1016/s0021-9258(19)66977-2
Publikováno v:
Clinical Biochemistry. 14:230-236
This review reports the use of recombinant DNA techniques in the study of the structure and regulation of expression of insulin genes in man and experimental animals. Insulin biosynthesis by pancreatic islet cells is predominantly regulated by change
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67241adf5e9724bb6c46dde316302ade
https://doi.org/10.1016/s0009-9120(81)90940-1
https://doi.org/10.1016/s0009-9120(81)90940-1
Autor:
Chirgwin John Mitchell, Peter M. Hobart, Barbra A. O'Connor, Ida M. Schaefer, Michael Fogliano
Publikováno v:
Proceedings of the National Academy of Sciences. 81:5026-5030
The complete protein precursor of human kidney renin has been determined from the sequence of cloned genomic DNA. The gene spans 12 kilobases of DNA and is interrupted by eight intervening sequences. The nine regions (exons) encoding the protein were
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f21e6ec01af4d1444a62316eae85b79f
https://doi.org/10.1073/pnas.81.16.5026
https://doi.org/10.1073/pnas.81.16.5026