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Dynamin inhibitors induce caspase-mediated apoptosis following cytokinesis failure in human cancer cells and this is blocked by Bcl-2 overexpression

Autor: Braithwaite Antony W, Joshi Sanket, Robinson Phillip J, Chircop Megan

Publikováno v: Molecular Cancer, Vol 10, Iss 1, p 78 (2011)

Abstract Background The aim of both classical (e.g. taxol) and targeted anti-mitotic agents (e.g. Aurora kinase inhibitors) is to disrupt the mitotic spindle. Such compounds are currently used in the clinic and/or are being tested in clinical trials

Externí odkaz: https://doaj.org/article/3ccfb57c39cb4468a0abdcc649d021ec

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Building a Better Dynasore: The Dyngo Compounds Potently Inhibit Dynamin and Endocytosis

Autor: McCluskey, Adam, Daniel, James A, Hadzic, Gordana, Chau, Ngoc, Clayton, Emma L, Mariana, Anna, Whiting, Ainslie, Gorgani, Nick N, Lloyd, Jonathan, Quan, Annie, Moshkanbaryans, Lia, Krishnan, Sai, Perera, Swetha, Chircop, Megan, von Kleist, Lisa, McGeachie, Andrew B, Howes, Mark T, Parton, Robert G, Campbell, Michael, Sakoff, Jennette A, Wang, Xuefeng, Sun, Jian-Yuan, Robertson, Mark J, Deane, Fiona M, Nguyen, Tam H, Meunier, Frederic A, Cousin, Michael A, Robinson, Phillip J

Publikováno v: Traffic (Copenhagen, Denmark)
McCluskey, A, Daniel, J A, Hadzic, G, Chau, N, Clayton, E L, Mariana, A, Whiting, A, Gorgani, N N, Lloyd, J, Quan, A, Moshkanbaryans, L, Krishnan, S, Perera, S, Chircop, M, von Kleist, L, McGeachie, A B, Howes, M T, Parton, R G, Campbell, M, Sakoff, J A, Wang, X, Sun, J-Y, Robertson, M J, Deane, F M, Nguyen, T H, Meunier, F A, Cousin, M A & Robinson, P J 2013, ' Building a better dynasore : the dyngo compounds potently inhibit dynamin and endocytosis ', Traffic, vol. 14, no. 12, pp. 1272-89 . https://doi.org/10.1111/tra.12119

Dynamin GTPase activity increases when it oligomerizes either into helices in the presence of lipid templates or into rings in the presence of SH3 domain proteins. Dynasore is a dynamin inhibitor of moderate potency (IC₅₀ ~ 15 μM in vitro). We s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::376b1fd71eba7bf6d7f5c406b5f1ca37
http://europepmc.org/articles/PMC4138991

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