Zobrazeno 1 - 10
of 68
pro vyhledávání: '"Chirayu Chokshi"'
Autor:
Michelle M. Kameda-Smith, Helen Zhu, En-Ching Luo, Yujin Suk, Agata Xella, Brian Yee, Chirayu Chokshi, Sansi Xing, Frederick Tan, Raymond G. Fox, Ashley A. Adile, David Bakhshinyan, Kevin Brown, William D. Gwynne, Minomi Subapanditha, Petar Miletic, Daniel Picard, Ian Burns, Jason Moffat, Kamil Paruch, Adam Fleming, Kristin Hope, John P. Provias, Marc Remke, Yu Lu, Tannishtha Reya, Chitra Venugopal, Jüri Reimand, Robert J. Wechsler-Reya, Gene W. Yeo, Sheila K. Singh
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
MYC amplification is an independent prognostic factor for the most aggressive subgroup (Group 3) of pediatric medulloblastoma (G3 MB). Here, the authors highlight the role of the RNA-binding protein, Musashi-1 (MSI1) in G3 MB and identify MSI1-bound
Externí odkaz:
https://doaj.org/article/3eace71e4f774decb598d79c690ed3aa
Autor:
Kevin Brown, Sheila Singh, Hong Han, Mathieu Seyfrid, William Thomas Maich, Vaseem Muhammad Shaikh, Nazanin Tatari, Deepak Upreti, Deween Piyasena, Minomi Subapanditha, Neil Savage, Dillon McKenna, Nicholas Mikolajewicz, Chirayu Chokshi, Laura Kuhlmann, Amanda Khoo, Sabra Khalid Salim, Blessing Archibong-Bassey, William Gwynne, Nadeem Murtaza, David Bakhshinyan, Parvez Vora, Chitra Venugopal, Jason Moffat, Thomas Kislinger
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 10, Iss 1 (2022)
Externí odkaz:
https://doaj.org/article/58fa9edb89474cc79d6aba282cfc533f
Autor:
Michelle M. Kameda-Smith, Helen Zhu, En-Ching Luo, Yujin Suk, Agata Xella, Brian Yee, Chirayu Chokshi, Sansi Xing, Frederick Tan, Raymond G. Fox, Ashley A. Adile, David Bakhshinyan, Kevin Brown, William D. Gwynne, Minomi Subapanditha, Petar Miletic, Daniel Picard, Ian Burns, Jason Moffat, Kamil Paruch, Adam Fleming, Kristin Hope, John P. Provias, Marc Remke, Yu Lu, Tannishtha Reya, Chitra Venugopal, Jüri Reimand, Robert J. Wechsler-Reya, Gene W. Yeo, Sheila K. Singh
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/a3f8e3d5b4894e4aa4350454d71f0f4e
Autor:
Sheila K. Singh, Sachdev Sidhu, Jason Moffat, David Kaplan, Johan Nilvebrant, Naresh K. Murty, Kevin R. Brown, Natalie Grinshtein, David Bobrowski, Alexander Gont, Max London, Chirayu Chokshi, Jiahe Yang, Neil Savage, Minomi K. Subapanditha, Maryna Gorelik, Amy Hu, Mohini Singh, Jarrett Adams, Chitra Venugopal, Parvez Vora, Maleeha A. Qazi
Glioblastoma (GBM) carries a dismal prognosis and inevitably relapses despite aggressive therapy. Many members of the Eph receptor tyrosine kinase (EphR) family are expressed by GBM stem cells (GSC), which have been implicated in resistance to GBM th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5839f426a7976b2e29484db2fef4779e
https://doi.org/10.1158/0008-5472.c.6512080
https://doi.org/10.1158/0008-5472.c.6512080
Autor:
Sheila K. Singh, Sachdev Sidhu, Jason Moffat, David Kaplan, Johan Nilvebrant, Naresh K. Murty, Kevin R. Brown, Natalie Grinshtein, David Bobrowski, Alexander Gont, Max London, Chirayu Chokshi, Jiahe Yang, Neil Savage, Minomi K. Subapanditha, Maryna Gorelik, Amy Hu, Mohini Singh, Jarrett Adams, Chitra Venugopal, Parvez Vora, Maleeha A. Qazi
Protein expression of EphA2, EphA3, CD133, CD15, Bmi1, Sox2, FoxG1 and ITGA6 in GBM.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c1935ad29429eaf1a3ae77b3efbd606
https://doi.org/10.1158/0008-5472.22425589.v1
https://doi.org/10.1158/0008-5472.22425589.v1
Autor:
Sheila K. Singh, Sachdev Sidhu, Jason Moffat, David Kaplan, Johan Nilvebrant, Naresh K. Murty, Kevin R. Brown, Natalie Grinshtein, David Bobrowski, Alexander Gont, Max London, Chirayu Chokshi, Jiahe Yang, Neil Savage, Minomi K. Subapanditha, Maryna Gorelik, Amy Hu, Mohini Singh, Jarrett Adams, Chitra Venugopal, Parvez Vora, Maleeha A. Qazi
Patient demographics.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09041ba6988404cf92d42f31f4f80762
https://doi.org/10.1158/0008-5472.22425562.v1
https://doi.org/10.1158/0008-5472.22425562.v1
Autor:
Neil Savage, Franz Zemp, Nick Mikolajewicz, Hong Han, Chitra Venugopal, Chirayu Chokshi, Nazanin Tatari, Thomas Kislinger, Jason Moffat, Doug Mahoney, Sheila Singh
Publikováno v:
Regular and Young Investigator Award Abstracts.
Autor:
Zsolt Zador, Nicholas Mikolajewicz, Hong Han, Mathew Voisin, Chitra Venugopal, Chirayu Chokshi, Will Maich, Moffat Jason, Gelareh Zadeh, Sheila Singh
Publikováno v:
Neuro-Oncology. 24:vii291-vii292
Persister states are proposed oncogenic substrates of disease recurrence in cancer. Recent concepts suggest persisters may occur in dynamic states of the cell cycle (such as cycling and non-cycling states). We therefore investigated biological progra
Autor:
Sheila Singh, Chirayu Chokshi, David Tieu, Kevin Brown, Chitra Venugopal, Martin Rossotti, Katherine Chan, Amy Tong, Laura Kuhlmann, Lina Liu, Benjamin Brakel, Vaseem Shaikh, William Maich, Yujin Suk, Daniel Mobilio, Neil Savage, Nikoo Aghaei, Minomi Subapanditha, Dillon McKenna, Vladimir Ignatchenko, Joseph Salamoun, Peter Wipf, Elizabeth Sharlow, John Provias, Jian-Qiang Lu, Naresh Murty, John Lazo, Thomas Kislinger, Kevin Henry, Yu Lu, Jason Moffat
Resistance to genotoxic therapies and tumor recurrence are hallmarks of glioblastoma (GBM), an aggressive brain tumor. Here, we explore the functional drivers of post-treatment recurrent GBM. By conducting genome-wide CRISPR-Cas9 screens in patient-d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::934ca2c72f06c0fdd3cbf32e27e60300
https://doi.org/10.21203/rs.3.rs-1871890/v1
https://doi.org/10.21203/rs.3.rs-1871890/v1
Autor:
William D. Gwynne, Yujin Suk, Stefan Custers, Nicholas Mikolajewicz, Jeremy K. Chan, Zsolt Zador, Shawn C. Chafe, Kui Zhai, Laura Escudero, Cunjie Zhang, Olga Zaslaver, Chirayu Chokshi, Muhammad Vaseem Shaikh, David Bakhshinyan, Ian Burns, Iqra Chaudhry, Omri Nachmani, Daniel Mobilio, William T. Maich, Patricia Mero, Kevin R. Brown, Andrew T. Quaile, Chitra Venugopal, Jason Moffat, J. Rafael Montenegro-Burke, Sheila K. Singh
Publikováno v:
Cancer cell. 40(12)
MYC-driven medulloblastoma (MB) is an aggressive pediatric brain tumor characterized by therapy resistance and disease recurrence. Here, we integrated data from unbiased genetic screening and metabolomic profiling to identify multiple cancer-selectiv