Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Chiranjeev Sharma"'
Publikováno v:
Biomolecules, Vol 14, Iss 3, p 310 (2024)
Diabetes and its associated complications have increasingly become major challenges for global healthcare. The current therapeutic strategies involve insulin replacement therapy for type 1 diabetes (T1D) and small-molecule drugs for type 2 diabetes (
Externí odkaz:
https://doaj.org/article/72dc85f879804ea59a7b7b1139e2f30c
Publikováno v:
ACS Omega, Vol 5, Iss 12, Pp 6472-6480 (2020)
Externí odkaz:
https://doaj.org/article/d8650d3daafe42f4a11baaef451b3115
Publikováno v:
Nutrients, Vol 14, Iss 19, p 3889 (2022)
Among all the NAD+ precursors, nicotinamide riboside (NR) has gained the most attention as a potent NAD+-enhancement agent. This recently discovered vitamin, B3, has demonstrated excellent safety and efficacy profiles and is orally bioavailable in hu
Externí odkaz:
https://doaj.org/article/dcb18272489345aebc7889de913a6e44
Publikováno v:
Biomolecules, Vol 12, Iss 8, p 1109 (2022)
Inhibition of Plasmodium falciparum nicotinamidase could represent a potential antimalarial since parasites require nicotinic acid to successfully recycle nicotinamide to NAD+, and importantly, humans lack this biosynthetic enzyme. Recently, mechanis
Externí odkaz:
https://doaj.org/article/4abcd91df22840f38cea03ca3b884ac5
Publikováno v:
Molecules, Vol 27, Iss 5, p 1655 (2022)
PROTACs employ the proteosome-mediated proteolysis via E3 ligase and recruit the natural protein degradation machinery to selectively degrade the cancerous proteins. Herein, we have designed and synthesized heterobifunctional small molecules that con
Externí odkaz:
https://doaj.org/article/5b39aadd098b4415afbc18cb5f2e6a3a
Autor:
Chiranjeev Sharma, Young Ho Seo
Publikováno v:
Molecules, Vol 23, Iss 11, p 2757 (2018)
Targeted therapy is an emerging paradigm in the development of next-generation anticancer drugs. Heat shock factor 1 (HSF1) has been identified as a promising drug target because it regulates several pathways responsible for cancer cell growth, metas
Externí odkaz:
https://doaj.org/article/b922eb3ce4d44da7901fbe038c2cdf31
Publikováno v:
RSC Advances. 13:11771-11781
Multifunctional activity-based chemical probes enable sirtuin labeling, affinity capture, PROTAC construction, and inhibitor discovery.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0ae9a245b7124deea39357b002193c20
https://doi.org/10.1039/d3ra02133e
https://doi.org/10.1039/d3ra02133e
Publikováno v:
Archives of Pharmacal Research. 44:310-321
Protein tyrosine phosphatases (PTPs) have an emerging paradigm for the development of antidiabetic drugs. Herein, we provide a comprehensive overview of the relevance of PTPs to type 2 diabetes (T2D) and the therapeutic opportunities thereof, while c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9b98b3f34628bca608bd5e97e34eb28
https://doi.org/10.1007/s12272-021-01315-9
https://doi.org/10.1007/s12272-021-01315-9
Autor:
Preeti Singh, Chiranjeev Sharma, Bhawana Sharma, Anupam Mishra, Drishti Agarwal, Deepika Kannan, Jana Held, Shailja Singh, Satish K. Awasthi
Publikováno v:
European journal of medicinal chemistry. 244
The artemisinin resistance has posed a serious threat against malaria elimination lately. Past few years have seen important development of several peroxide based medicinal compounds and their derivatives such as trioxanes and tetraoxanes. Here, we r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::caaf1896ddc05f6fab8eed4f9bb0f94e
https://pubmed.ncbi.nlm.nih.gov/36306538
https://pubmed.ncbi.nlm.nih.gov/36306538
Autor:
TaeJin Lee, Ju Hwan Kim, Se Jeong Kwon, Jin Woo Seo, Sun Hee Park, Jinyoung Kim, Jonghwa Jin, Ji Hye Hong, Hyo Jin Kang, Chiranjeev Sharma, Ji Hoon Choi, Sang J. Chung
Publikováno v:
Journal of medicinal chemistry. 65(7)
Immunoglobulin Gs (IgGs) contain many Lys and Cys residues, which results in an unwanted complex product mixture with conventional drug conjugation methods. We selectively acylated the ε-NH
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b54b58b173fd4432ef37c62ac401da2
https://pubmed.ncbi.nlm.nih.gov/35319890
https://pubmed.ncbi.nlm.nih.gov/35319890