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pro vyhledávání: '"Chiral pool synthesis"'
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Publikováno v:
Archiv der PharmazieREFERENCES. 355(2)
Two independent chiral pool syntheses of both enantiomers of the TRPML inhibitor, trans-ML-SI3, were developed, starting from commercially available (1S,2R)- and (1R,2S)-configured cis-2-aminocyclohexanols. Both routes lead to the target compounds in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::248c0b8beeaedc630227ecbe9aa728a7
https://pubmed.ncbi.nlm.nih.gov/34738656
https://pubmed.ncbi.nlm.nih.gov/34738656
Autor:
Kirstin Lehmkuhl, Patrizia Diana, Hendrik Jonas, Jens Köhler, Dirk Schepmann, Daniele Aiello, Bernhard Wünsch, Bastian Frehland
Conformationally restricted bicyclic KOR agonists 10 with an endo configured amino moiety were synthesized to analyze the bioactive conformation of conformationally flexible KOR agonists such as 2-5. A seven-step, chiral pool synthesis starting with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eaea984e7f93d339c717b4dac4c9a226
http://hdl.handle.net/10447/521671
http://hdl.handle.net/10447/521671
Autor:
Wolfgang Sippl, Stefan Wagner, Jelena Melesina, Burkhard Riemann, Hélène Van de Vyver, Dmitrii V. Kalinin, Bettina Löffler, Ralph Holl, Michael Schäfers, Oriana Agoglitta
Publikováno v:
Bioorganic & Medicinal Chemistry. 27:1997-2018
The Zn2+-dependent deacetylase LpxC is an essential enzyme in Gram-negative bacteria, which has been validated as antibacterial drug target. Herein we report the chiral-pool synthesis of novel d - and l -proline-derived 3,4-dihydroxypyrrolidine hydro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be97ff8ee7e901db5181b4956431f561
https://doi.org/10.1016/j.bmc.2019.03.056
https://doi.org/10.1016/j.bmc.2019.03.056
Autor:
Ralph Holl, Alexander Dreger, Wolfgang Sippl, Oriana Agoglitta, Omar Kharwb, Emre F. Bülbül, Jelena Melesina
Publikováno v:
ChemMedChem. 14:871-886
Inhibitors of the bacterial deacetylase LpxC are a promising class of novel antibiotics, being selectively active against Gram-negative bacteria. To improve the biological activity of reported C-furanosidic LpxC inhibitors, the stereochemistry at pos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da8a8df119f21a883c5635b61d97bc58
https://doi.org/10.1002/cmdc.201900068
https://doi.org/10.1002/cmdc.201900068
Publikováno v:
Chemistry (Weinheim an Der Bergstrasse, Germany)
Pseudaminic acid (Pse) is a significant prokaryotic monosaccharide found in important Gram‐negative and Gram‐positive bacteria. This unique sugar serves as a component of cell‐surface‐associated glycans or glycoproteins and is associated with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b627ba42b0f3d1e34c9077cda89687e
https://doi.org/10.1002/chem.202100443
https://doi.org/10.1002/chem.202100443
Autor:
Lucía Viejo, María Isabel Rodríguez-Franco, Elies Molins, Daniel J. V. A. dos Santos, Lídia Gonçalves, Maria M. M. Santos, Clara Herrera-Arozamena, Cristóbal de los Ríos, Margarida Espadinha, Ricardo M R M Lopes
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
instname
N-Methyl-D-aspartate receptors (NMDARs) are crucial for the normal function of the central nervous system (CNS), and fundamental in memory and learning-related processes. The overactivation of these receptors is associated with numerous neurodegenera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a397ed2a33305f849048690268adb758
http://hdl.handle.net/10261/219127
http://hdl.handle.net/10261/219127
Publikováno v:
Tetrahedron Letters. 60:1597-1599
Herein we report our efforts toward unequivocal assignment of the hitherto unknown absolute configurations of two naturally occurring phenylpropanoids from Abies delavayi and Abies fabri via a combination of chiral pool synthesis and single crystal X
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::493d16f576c3708a2d385742cd2aaa95
https://doi.org/10.1016/j.tetlet.2019.05.022
https://doi.org/10.1016/j.tetlet.2019.05.022