Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Chirag Mandavia"'
Autor:
Chirag Mandavia
Publikováno v:
Medical Hypotheses. 84:204-208
The environmental toxin 2,3,7,8 tetrachlorodibenzo p-dioxin (TCDD) plays an important role in the development of chloracne. Chloracne is characterized by hyperkeratosis of the interfollicular squamous epithelium and metaplasia of sebaceous glands. Dy
Publikováno v:
Life Sciences. 92:601-608
Diabetes mellitus type 2 (T2DM) is a widespread chronic medical condition with prevalence bordering on the verge of an epidemic. It is of great concern that cardiovascular disease is more common in patients with diabetes than the non-diabetic populat
Publikováno v:
Heart Failure Clinics. 8:609-617
This article addresses the issue of insulin resistance and associated reductions in cardiac insulin metabolic signaling, which is emerging as a major factor in the development of heart failure, and assumes more importance because of an epidemic incre
Publikováno v:
Cardiorenal Medicine. 2:268-280
Since the classic experiments by Tigerstedt and Bergman that established the role of renin in hypertension a century ago, aggressive efforts have been launched to effectively block the renin-angiotensin system (RAS). Blockade of RAS is advocated at m
Autor:
James R. Sowers, Catherine Sinak, Alex Meuth, Thomas J. Thekkumkara, Robert C. Speth, Bradley T. Andresen, Ravi Nistala, Lakshmi Pulakat, Chirag Mandavia, Adam Whaley-Connell
Blockade of the angiotensin (ANG) II receptor type 1 (AT1R) with angiotensin receptor blockers (ARBs) is widely used in the treatment of hypertension. However, ARBs are variably effective in reducing blood pressure, likely due, in part, to polymorphi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::446d58686d54c02d8822ec3b9cba5302
https://europepmc.org/articles/PMC3625841/
https://europepmc.org/articles/PMC3625841/
Autor:
Chirag Mandavia, James R. Sowers
Insulin (INS) metabolic signaling is important for normal cardiovascular and renal function as well as for exerting the classic actions of INS, such as glucose uptake in skeletal muscle tissue. There is emerging evidence that tyrosine phosphatases as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d29e6366129101f0ba998a76a2c6f7e
https://europepmc.org/articles/PMC3551395/
https://europepmc.org/articles/PMC3551395/
Cardiovascular disease, which accounts for the highest morbidity and mortality in the United States, has several major risk factors, including aging and diabetes. Overweight and obesity, especially abdominal obesity, have been increasingly implicated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c388eabe59afef87c3ab75f81214d64
https://europepmc.org/articles/PMC3393834/
https://europepmc.org/articles/PMC3393834/
Mitochondria play a fundamental role in the maintenance of normal structure, function, and survival of tissues. There is considerable evidence for mitochondrial dysfunction in association with metabolic diseases including insulin resistance, obesity,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b82600500bfa1810f1a8857b434e6d33
https://europepmc.org/articles/PMC3357146/
https://europepmc.org/articles/PMC3357146/
Publikováno v:
The FASEB Journal. 22