Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Chirag M. Lakhani"'
Autor:
Sara J. Cromer, Chirag M. Lakhani, Josep M. Mercader, Timothy D. Majarian, Philip Schroeder, Joanne B. Cole, Jose C. Florez, Chirag J. Patel, Alisa K. Manning, Sherri-Ann M. Burnett-Bowie, Jordi Merino, Miriam S. Udler
OBJECTIVE Quantify the impact of genetic and socioeconomic factors on risk of type 2 diabetes (T2D) and obesity. RESEARCH DESIGN AND METHODS Among participants in the Mass General Brigham Biobank (MGBB) and UK Biobank (UKB), we used logistic regressi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2cb83380ceb2e7bf50ab865434d96ff
https://doi.org/10.2337/figshare.21754235
https://doi.org/10.2337/figshare.21754235
Autor:
Bryan Andrews, Chirayu Wongchokprasitti, Shyam Visweswaran, Chirag M. Lakhani, Chirag J. Patel, Gregory F. Cooper
Publikováno v:
Artificial Intelligence in Medicine. 139:102546
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b1d379102393fae7576bfa54b6768b3c
https://doi.org/10.1016/j.artmed.2023.102546
https://doi.org/10.1016/j.artmed.2023.102546
Autor:
Devi Sai Sri Kavya Boorgu, Shruthi Venkatesh, Chirag M. Lakhani, Elizabeth Walker, Ines M. Aguerre, Claire Riley, Chirag J. Patel, Philip L. De Jager, Zongqi Xia
Publikováno v:
Mult Scler Relat Disord
BACKGROUND: To examine whether lower neighborhood-level and individual-level indicators of socioeconomic status (SES) are associated with subsequently worse neurological disability in people with MS (pwMS). METHODS: In a multi-center study using pros
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1985e261c8259b6cd397baacc6a1ad8b
https://pubmed.ncbi.nlm.nih.gov/35780727
https://pubmed.ncbi.nlm.nih.gov/35780727
Autor:
Chirag M. Lakhani, Miriam S. Udler, Jose C. Florez, Tim Majarian, Jordi Merino, Josep M. Mercader, Alisa K. Manning, Sara Jane Cromer
Publikováno v:
Diabetes. 70
Genetics and socioeconomic status (SES) are key drivers of increased type 2 diabetes (T2D) risk, but the extent to which they impact disease in an additive or non-additive manner is unknown. We examined T2D prevalence using cross-sectional electronic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::96d1a56f27972c2bcfae68625430f6b9
https://doi.org/10.2337/db21-325-or
https://doi.org/10.2337/db21-325-or
Autor:
Peter M. Visscher, Braden T. Tierney, Chirag J. Patel, Jian Yang, Arjun K. Manrai, Chirag M. Lakhani
Publikováno v:
Nature genetics
We analyzed a large health insurance dataset to assess the genetic and environmental contributions of 560 disease-related phenotypes in 56,396 twin pairs and 724,513 sibling pairs out of 44,859,462 individuals that live in the United States. We estim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73bf2620bc6b9e1477b0a5afb9db2c67
http://europepmc.org/articles/PMC6358510
http://europepmc.org/articles/PMC6358510
Autor:
Ioanna Tzoulaki, Chirag J. Patel, Yixuan He, Danielle Rasooly, Chirag M. Lakhani, Arjun K. Manrai
Publikováno v:
Diabetes Care
OBJECTIVE To establish a polyexposure score (PXS) for type 2 diabetes (T2D) incorporating 12 nongenetic exposures and examine whether a PXS and/or a polygenic risk score (PGS) improves diabetes prediction beyond traditional clinical risk factors. RES
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2de1eef87d7b2a956e18ead319b699b8
https://doi.org/10.2337/figshare.13607828.v2
https://doi.org/10.2337/figshare.13607828.v2
Autor:
Deborah J. Wexler, Chirag M. Lakhani, Sherri-Ann M. Burnett-Bowie, Miriam S. Udler, Sara Jane Cromer, Chirag J. Patel
Publikováno v:
medRxiv
article-version (status) pre
article-version (number) 1
article-version (status) pre
article-version (number) 1
BackgroundThe SARS-CoV-2 pandemic has disproportionately affected racial and ethnic minority communities across the United States. We sought to disentangle individual and census tract-level sociodemographic and economic factors associated with these
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::068292407eb1d2cd15b0f70f173573b3
https://doi.org/10.1101/2020.09.30.20201830
https://doi.org/10.1101/2020.09.30.20201830
Publikováno v:
JMIR Public Health and Surveillance
Background Although it is well-known that older individuals with certain comorbidities are at the highest risk for complications related to COVID-19 including hospitalization and death, we lack tools to identify communities at the highest risk with f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4397c1a3aa8a0e9458be9e503bbdb718
https://doi.org/10.2196/26604
https://doi.org/10.2196/26604
While polygenic risk scores (PRSs) have been shown to identify a small number of individuals with increased clinical risk for several common diseases, non-genetic factors that change during a lifetime, such as lifestyle, employment, diet, and polluti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d14449e940fe36ff006e83a7c79eec15
https://doi.org/10.1101/833632
https://doi.org/10.1101/833632
Autor:
Jian Yang, Chirag J. Patel, Peter M. Visscher, Arjun K. Manrai, Braden T. Tierney, Chirag M. Lakhani
Publikováno v:
Nature Genetics. 51:764-765
In the version of this article initially published, in Fig. 4b, the shared environmental variance (c2) values for all MaTCH functional domains except ‘all traits’ were erroneously estimated because of a coding error. Figure 4 has been revised to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::20ae951e4c19649a7d7033cc580b9389
https://doi.org/10.1038/s41588-019-0377-z
https://doi.org/10.1038/s41588-019-0377-z