Zobrazeno 1 - 10
of 154
pro vyhledávání: '"Chirag G. Patil"'
Autor:
Robert H. Baloh, J. Patrick Johnson, Pablo Avalos, Peggy Allred, Soshana Svendsen, Genevieve Gowing, Kristina Roxas, Amanda Wu, Becky Donahue, Sheryl Osborne, George Lawless, Brandon Shelley, Koral Wheeler, Carolyn Prina, Dana Fine, Tami Kendra-Romito, Haniah Stokes, Vicki Manoukian, Abirami Muthukumaran, Leslie Garcia, Maria G. Bañuelos, Marlesa Godoy, Catherine Bresee, Hong Yu, Doniel Drazin, Lindsey Ross, Robert Naruse, Harish Babu, Eric A. Macklin, Ashley Vo, Ashraf Elsayegh, Warren Tourtellotte, Marcel Maya, Matthew Burford, Frank Diaz, Chirag G. Patil, Richard A. Lewis, Clive N. Svendsen
Publikováno v:
Nature Medicine. 28:1813-1822
Amyotrophic lateral sclerosis (ALS) involves progressive motor neuron loss, leading to paralysis and death typically within 3–5 years of diagnosis. Dysfunctional astrocytes may contribute to disease and glial cell line-derived neurotrophic factor (
Autor:
Chirag G. Patil, Padraig Buckley, Ryosuke Yamada, Kunal Varshneya, Alexey Bazarov, Christopher J. Wheeler, Kolin C. Hribar
A cell culture platform that enables ex vivo tissue growth from patients or patient-derived xenograft (PDX) models and assesses sensitivity to approved therapies (e.g., temozolomide) in a clinically relevant time frame would be very useful in transla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1810a772b43ecc2c1e81c9499e1235d4
https://doi.org/10.1158/1535-7163.c.6538006.v1
https://doi.org/10.1158/1535-7163.c.6538006.v1
Autor:
Chirag G. Patil, Padraig Buckley, Ryosuke Yamada, Kunal Varshneya, Alexey Bazarov, Christopher J. Wheeler, Kolin C. Hribar
Supplementary Figure 1: spheroid growth in VersaGel using tumor cell lines. A) HepG2 hepatocarcinoma cell line; B) LN18 glioblastoma cell line. Scale bar = 1 millimeter. Supplementary Figure 2: VersaGel vs. BME (Matrigel) for Patient 4, Partial Respo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a8d5717779e4b782c4cca8554103850
https://doi.org/10.1158/1535-7163.22505251
https://doi.org/10.1158/1535-7163.22505251
Autor:
Julia Y. Ljubimova, Keith L. Black, Alexander V. Ljubimov, Eggehard Holler, Manuel L. Penichet, Tracy R. Daniels-Wells, Lai S. Leoh, Yongmei L. Chen, Alexander V. Lyubimov, Vida Falahatian, Arthur Rekechenetskiy, Zachary B. Grodzinski, Jethro Hu, Jeremy D. Rudnick, Chirag G. Patil, Serguei I. Bannykh, Adam N. Mamelak, Debiao Li, Shawn Wagner, Ekaterina S. Shatalova, Vladimir A. Ljubimov, Frank B. Furnari, Webster K. Cavenee, Alexandra Chesnokova, Hui Ding, Dmytro Klymyshyn, Anna Galstyan, Rameshwar Patil, Tao Sun
Figures S2, S3 and S4. Morphometric analysis of laminin-411 β1 chain (S2) and cancer stem cell markers (Notch-1, Notch-3, CD133, Nestin, and c-Myc; S3 and S4) on frozen sections of patient brain tumors. The expression of all markers significantly co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7954ae943f08a0594bc3fcdb183822b6
https://doi.org/10.1158/0008-5472.22423184.v1
https://doi.org/10.1158/0008-5472.22423184.v1
Autor:
Julia Y. Ljubimova, Keith L. Black, Alexander V. Ljubimov, Eggehard Holler, Manuel L. Penichet, Tracy R. Daniels-Wells, Lai S. Leoh, Yongmei L. Chen, Alexander V. Lyubimov, Vida Falahatian, Arthur Rekechenetskiy, Zachary B. Grodzinski, Jethro Hu, Jeremy D. Rudnick, Chirag G. Patil, Serguei I. Bannykh, Adam N. Mamelak, Debiao Li, Shawn Wagner, Ekaterina S. Shatalova, Vladimir A. Ljubimov, Frank B. Furnari, Webster K. Cavenee, Alexandra Chesnokova, Hui Ding, Dmytro Klymyshyn, Anna Galstyan, Rameshwar Patil, Tao Sun
Video schematically shows the mechanism of glioblastoma treatment by laminin-411 inhibiting nanobioconjugate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b1bcf1d94d457d8f4402664174692d4
https://doi.org/10.1158/0008-5472.22423166.v1
https://doi.org/10.1158/0008-5472.22423166.v1
Autor:
Julia Y. Ljubimova, Keith L. Black, Alexander V. Ljubimov, Eggehard Holler, Manuel L. Penichet, Tracy R. Daniels-Wells, Lai S. Leoh, Yongmei L. Chen, Alexander V. Lyubimov, Vida Falahatian, Arthur Rekechenetskiy, Zachary B. Grodzinski, Jethro Hu, Jeremy D. Rudnick, Chirag G. Patil, Serguei I. Bannykh, Adam N. Mamelak, Debiao Li, Shawn Wagner, Ekaterina S. Shatalova, Vladimir A. Ljubimov, Frank B. Furnari, Webster K. Cavenee, Alexandra Chesnokova, Hui Ding, Dmytro Klymyshyn, Anna Galstyan, Rameshwar Patil, Tao Sun
Figure S5. Binding of the nanobioconjugates to U87MG studied by flow cytometry is inhibited by human soluble TfR. This shows that the chimeric anti-human TfR antibody as part of nanobioconjugate fully retained its activity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a3255e723448b91bdefabf1741fac2b
https://doi.org/10.1158/0008-5472.22423181
https://doi.org/10.1158/0008-5472.22423181
Autor:
John S. Yu, Rongfu Wang, Stephen L. Shiao, Keith L. Black, Chirag G. Patil, Ray M. Chu, Toni Ganaway, Mia Mazer, Hongqiang Wang, Surasak Phuphanich, Mourad Tighiouart, Sungjin Kim, Jeremy D. Rudnick, Oluwaseun A. Omofoye, Jethro L. Hu
Purpose:Glioblastoma (GBM) is a heterogeneous malignancy with multiple subpopulations of cancer cells present within any tumor. We present the results of a phase I clinical trial using an autologous dendritic cell (DC) vaccine pulsed with lysate deri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87f039b07666b8b51ad1599f07b88128
https://doi.org/10.1158/1078-0432.c.6530820.v1
https://doi.org/10.1158/1078-0432.c.6530820.v1
Autor:
John S. Yu, Rongfu Wang, Stephen L. Shiao, Keith L. Black, Chirag G. Patil, Ray M. Chu, Toni Ganaway, Mia Mazer, Hongqiang Wang, Surasak Phuphanich, Mourad Tighiouart, Sungjin Kim, Jeremy D. Rudnick, Oluwaseun A. Omofoye, Jethro L. Hu
Supplementary Data from A Phase I Study of Autologous Dendritic Cell Vaccine Pulsed with Allogeneic Stem-like Cell Line Lysate in Patients with Newly Diagnosed or Recurrent Glioblastoma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41b5b15845b5aac4b794e8b448e60bdb
https://doi.org/10.1158/1078-0432.22482096.v1
https://doi.org/10.1158/1078-0432.22482096.v1
Autor:
Julia Y. Ljubimova, Keith L. Black, Alexander V. Ljubimov, Eggehard Holler, Manuel L. Penichet, Tracy R. Daniels-Wells, Lai S. Leoh, Yongmei L. Chen, Alexander V. Lyubimov, Vida Falahatian, Arthur Rekechenetskiy, Zachary B. Grodzinski, Jethro Hu, Jeremy D. Rudnick, Chirag G. Patil, Serguei I. Bannykh, Adam N. Mamelak, Debiao Li, Shawn Wagner, Ekaterina S. Shatalova, Vladimir A. Ljubimov, Frank B. Furnari, Webster K. Cavenee, Alexandra Chesnokova, Hui Ding, Dmytro Klymyshyn, Anna Galstyan, Rameshwar Patil, Tao Sun
Figure S10. Expression of Notch-1 and its ligand Jagged1 is significantly decreased in patient-derived glioblastoma cell lines with laminin-411 disruption by CRISPR/Cas9
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19cdcf76995919f58fa3d462d85011ad
https://doi.org/10.1158/0008-5472.22423172.v1
https://doi.org/10.1158/0008-5472.22423172.v1
Autor:
Julia Y. Ljubimova, Keith L. Black, Alexander V. Ljubimov, Eggehard Holler, Manuel L. Penichet, Tracy R. Daniels-Wells, Lai S. Leoh, Yongmei L. Chen, Alexander V. Lyubimov, Vida Falahatian, Arthur Rekechenetskiy, Zachary B. Grodzinski, Jethro Hu, Jeremy D. Rudnick, Chirag G. Patil, Serguei I. Bannykh, Adam N. Mamelak, Debiao Li, Shawn Wagner, Ekaterina S. Shatalova, Vladimir A. Ljubimov, Frank B. Furnari, Webster K. Cavenee, Alexandra Chesnokova, Hui Ding, Dmytro Klymyshyn, Anna Galstyan, Rameshwar Patil, Tao Sun
Figures S8 and S9. Quantification of expression of laminin-411 β1 chain, its binding β1 integrin, Notch family members and other stem cell markers after nanobioconjugate treatment. All markers were significantly suppressed in treated tumors.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c025739000157f1340b145f3c28041b
https://doi.org/10.1158/0008-5472.22423175.v1
https://doi.org/10.1158/0008-5472.22423175.v1