Výsledky vyhledávání - "Chirag D. Badami"

HIF-1 mediates pathogenic inflammatory responses to intestinal ischemia-reperfusion injury

Autor: Qi Lu, Iriana Colorado, Marta Bosch-Marce, Kolenkode B. Kannan, Madhuri Ramanathan, Sharvil U. Sheth, Rena Feinman, Francis J. Caputo, Edwin A. Deitch, Chirag D. Badami, Gregg L. Semenza, Billy Abungu, Anthony C. Watkins, Danielle Doucet, Da Zhong Xu, Dimitrios Barlos, Shirhan Attan

Publikováno v: American Journal of Physiology-Gastrointestinal and Liver Physiology. 299:G833-G843

Acute lung injury (ALI) and the development of the multiple organ dysfunction syndrome (MODS) are major causes of death in trauma patients. Gut inflammation and loss of gut barrier function as a consequence of splanchnic ischemia-reperfusion (I/R) ha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d90df5e3ccbc0653b91bc5ffbbc4cc65
https://doi.org/10.1152/ajpgi.00065.2010

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The Use of Barbiturate Coma as Salvage Therapy in a Postoperative Jehovah's Witness Patient with Life-Threatening Anemia

Autor: Chirag D. Badami, Steve W Wang, Edwin A. Deitch

Publikováno v: The American Surgeon. 75:1175-1178

Management of the patient who refuses blood products based on religious grounds poses ethical and clinical challenges, especially when the degree of anemia becomes life-threatening. In this report, we present the case of a 52-year-old Jehovah's Witne

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c2f3be5684c372b342489800303a564
https://doi.org/10.1177/000313480907501205

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MESENTERIC LYMPH DUCT LIGATION IMPROVES SURVIVAL IN A LETHAL SHOCK MODEL

Autor: Maheswari Senthil, Vadim Pisarenko, Qi Lu, Edwin A. Deitch, Chirag D. Badami, Bobby Rupani, Rena Feinman, Francis J. Caputo, Danielle Doucet, Da-Zhong Xu

Publikováno v: Shock. 30:680-685

The goal of this study was to test the hypothesis that factors released from the gut and carried in the mesenteric lymph contribute to mortality in a lethal gut I/R model. To test this hypothesis, a lethal splanchnic artery occlusion (SAO) shock mode

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe2032570575676667adbe2ba7905eab
https://doi.org/10.1097/shk.0b013e318173edd1

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The Influence of the Type of Resuscitation Fluid on Gut Injury and Distant Organ Injury in a Rat Model of Trauma/Hemorrhagic Shock

Autor: Tamara L. Berezina, Elenora Feketeova, Chirag D. Badami, Qi Lu, Dennis Vega, Sergey B. Zaets, Da Zhong Xu, Francis J. Caputo, Anthony C. Watkins, Edwin A. Deitch

Publikováno v: Journal of Trauma: Injury, Infection & Critical Care. 65:409-415

Background: Recognition that resuscitation with Ringers lactate (RL) potentiates trauma-hemorrhagic shock (T/HS)-induced organ injury and systemic inflammation has led to a search for improved initial fluid resuscitation regimens. However, one relati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9171b5276888bbc9c0c3d7668137acd5
https://doi.org/10.1097/ta.0b013e3181719708

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Cellular mechanisms of burn-related changes in contractility and its prevention by mesenteric lymph ligation

Autor: Justin T. Sambol, Chirag D. Badami, Atsuko Yatani, Da-Zhong Xu, Zhiqiang Yuan, Kentaro Kawai, Tomoko Kawai, Edwin A. Deitch, Francis J. Caputo

Publikováno v: American Journal of Physiology-Heart and Circulatory Physiology. 292:H2475-H2484

Major burn injury results in impairment of left ventricular (LV) contractile function. There is strong evidence to support the involvement of gut-derived factor(s) transported in mesenteric lymph in the development of burn-related contractile dysfunc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::795ef3b1e606efaa7250b2fb223befb5
https://doi.org/10.1152/ajpheart.01164.2006

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Estrogen receptor hormone agonists limit trauma hemorrhage shock-induced gut and lung injury in rats

Autor: Iriana Colorado, Danielle Doucet, R Paul Bonitz, Chirag D. Badami, Kolenkode B. Kannan, Edwin A. Deitch, Da Zhong Xu, Rena Feinman, David Palange, Qi Lu

Publikováno v: PLoS ONE, Vol 5, Iss 2, p e9421 (2010)
PLoS ONE

Background Acute lung injury (ALI) and the development of the multiple organ dysfunction syndrome (MODS) is a major cause of death in trauma patients. Earlier studies in trauma hemorrhagic shock (T/HS) have documented that splanchnic ischemia leading

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2566ba7421d3f4a87f6606f456947a7
http://europepmc.org/articles/PMC2828476?pdf=render

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Mesenteric lymph duct ligation prevents trauma/hemorrhage shock-induced cardiac contractile dysfunction

Autor: Francis J. Caputo, Marlon A. Lee, Atsuko Yatani, Justin Sambol, Edwin A. Deitch, Chirag D. Badami, Tomoko Kawai, Kentaro Kawai

Clinical and experimental studies have shown that trauma combined with hemorrhage shock (T/HS) is associated with myocardial contractile dysfunction. However, the initial events triggering the cardiac dysfunction are not fully elucidated. Thus we tes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36d723e79ed097016e717a8cc5d1b16a
https://europepmc.org/articles/PMC2636941/

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Mesenteric lymph duct ligation attenuates lung injury and neutrophil activation after intraperitoneal injection of endotoxin in rats

Autor: Eleanora Feketeova, Anthony C. Watkins, Edwin A. Deitch, Qi Lu, Dimitrios Barlos, Chirag D. Badami, Francis J. Caputo, Da Zhong Xu

Publikováno v: The Journal of trauma. 64(1)

The release of injurious factors into the mesenteric lymph from the ischemic intestine has been shown to contribute to lung injury and systemic inflammation after shock and trauma. Since endotoxemia is also associated with gut injury, we tested the h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6628ac6fc3aa036562fe3b6898e42cb8
https://pubmed.ncbi.nlm.nih.gov/18188110

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Trauma-shock-induced gut injury and the production of biologically active intestinal lymph is abrogated by castration in a large animal porcine model

Autor: Edwin A. Deitch, Qi Lu, Francis J. Caputo, Margaret Brown, Maheswari Senthil, Vadim Pisarenko, Eleonora Feketeova, Chirag D. Badami, Anthony C. Watkins, Danielle Doucet, Da-Zhong Xu, Devashish J. Anjaria

Publikováno v: Shock (Augusta, Ga.). 30(2)

Although small animal rodent studies indicate that there is a sexual dimorphism in the resistance to organ injury after trauma-hemorrhagic shock (T/HS), confirmatory studies are largely lacking in more clinically relevant large animal species. Thus,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71fc3bf8102d5ae3de3c74f808e22572
https://pubmed.ncbi.nlm.nih.gov/18180696

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Hematopoietic progenitor cells mobilize to the site of injury after trauma and hemorrhagic shock in rats

Autor: Francis J. Caputo, Alicia M. Mohr, Ziad C. Sifri, Edwin A. Deitch, Larissa Bonilla, David H. Livingston, Chirag D. Badami

Publikováno v: The Journal of trauma. 63(3)

BACKGROUND Trauma and hemorrhagic shock (T/HS) has been demonstrated to result in bone marrow (BM) suppression and the release of hematopoietic progenitor cells (HPC) into the peripheral blood in both human beings and experimental animals. HPC have a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8517a330979e0103c357d936088c0e86
https://pubmed.ncbi.nlm.nih.gov/18073606

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