A Classical Epithelial State Drives Acute Resistance to KRAS Inhibition in Pancreatic Cancer.

Autor: Singhal A; Cancer Biology and Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York.; David M. Rubenstein Center for Pancreatic Cancer, Memorial Sloan Kettering Cancer Center, New York, New York.; Gastrointestinal Oncology Service, Memorial Sloan Kettering Cancer Center, New York, New York., Styers HC; Cancer Biology and Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York., Rub J; Cancer Biology and Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York., Li Z; Cancer Biology and Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York.; Weill Cornell Graduate School of Medical Science, Weill Cornell Medicine, New York, New York., Torborg SR; Cancer Biology and Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York.; Weill Cornell/Rockefeller/Sloan Kettering Tri-Institutional MD-PhD Program, New York, New York., Kim JY; Cancer Biology and Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York., Grbovic-Huezo O; Cancer Biology and Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York., Feng H; Institute for Cancer Genetics, Department of Genetics and Development and Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, New York., Tarcan ZC; David M. Rubenstein Center for Pancreatic Cancer, Memorial Sloan Kettering Cancer Center, New York, New York.; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York., Sahin Ozkan H; David M. Rubenstein Center for Pancreatic Cancer, Memorial Sloan Kettering Cancer Center, New York, New York.; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York., Hallin J; Mirati Therapeutics, San Diego, California., Basturk O; David M. Rubenstein Center for Pancreatic Cancer, Memorial Sloan Kettering Cancer Center, New York, New York.; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York., Yaeger R; Gastrointestinal Oncology Service, Memorial Sloan Kettering Cancer Center, New York, New York., Christensen JG; Mirati Therapeutics, San Diego, California., Betel D; Institute for Computational Biomedicine, Weill Cornell Medicine, New York, New York.; Division of Hematology and Oncology, Department of Medicine, Weill Cornell Medicine, New York, New York., Yan Y; Cancer Biology and Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York., Chio IIC; Institute for Cancer Genetics, Department of Genetics and Development and Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, New York., de Stanchina E; Cancer Biology and Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York.; Antitumor Assessment Core Facility, Molecular Pharmacology Program, MSKCC, New York, New York., Tammela T; Cancer Biology and Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York.; David M. Rubenstein Center for Pancreatic Cancer, Memorial Sloan Kettering Cancer Center, New York, New York.

Publikováno v: Cancer discovery [Cancer Discov] 2024 Nov 01; Vol. 14 (11), pp. 2122-2134.

Targeted delivery of napabucasin with radiotherapy improves outcomes in diffuse midline glioma.

Autor: Gallitto M; Department of Radiation Oncology, Columbia University Vagelos College of Physicians and Surgeons and NewYork-Presbyterian, New York, NY, USA.; Herbert Irving Comprehensive Cancer Center, Columbia University Vagelos College of Physicians and Surgeons and NewYork-Presbyterian, New York, NY USA., Zhang X; Institute for Cancer Genetics, Department of Genetics and Development, Columbia University Irving Medical Center, New York, NY, USA., De Los Santos G; Department of Radiation Oncology, Columbia University Vagelos College of Physicians and Surgeons and NewYork-Presbyterian, New York, NY, USA., Wei HJ; Department of Radiation Oncology, Columbia University Vagelos College of Physicians and Surgeons and NewYork-Presbyterian, New York, NY, USA.; Herbert Irving Comprehensive Cancer Center, Columbia University Vagelos College of Physicians and Surgeons and NewYork-Presbyterian, New York, NY USA.; Department of Biomedical Engineering and Mechanics, Virginia Tech School of Medicine, Roanoke, VA., Fernández EC; Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA USA.; Broad Institute of MIT and Harvard, Cambridge, MA USA.; Department of Systems Biology, Columbia University Irving Medical Center, New York, NY, USA.; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY USA., Duan S; Institute for Cancer Genetics, Department of Genetics and Development, Columbia University Irving Medical Center, New York, NY, USA., Sedor G; Department of Radiation Oncology, Columbia University Vagelos College of Physicians and Surgeons and NewYork-Presbyterian, New York, NY, USA.; Herbert Irving Comprehensive Cancer Center, Columbia University Vagelos College of Physicians and Surgeons and NewYork-Presbyterian, New York, NY USA., Yoh N; Department of Neurological Surgery, Columbia University Irving Medical Center, New York, NY USA., Kokosi D; Department of Radiation Oncology, Columbia University Vagelos College of Physicians and Surgeons and NewYork-Presbyterian, New York, NY, USA., Angel JC; Department of Biomedical Informatics, Columbia University, New York, NY USA.; Department of Molecular Pharmacology and Therapeutics, Columbia University, New York, NY USA., Wang YF; Department of Radiation Oncology, Columbia University Vagelos College of Physicians and Surgeons and NewYork-Presbyterian, New York, NY, USA., White E; Department of Systems Biology, Columbia University Irving Medical Center, New York, NY, USA., Kinslow CJ; Department of Radiation Oncology, Columbia University Vagelos College of Physicians and Surgeons and NewYork-Presbyterian, New York, NY, USA.; Herbert Irving Comprehensive Cancer Center, Columbia University Vagelos College of Physicians and Surgeons and NewYork-Presbyterian, New York, NY USA., Berg X; Department of Radiation Oncology, Columbia University Vagelos College of Physicians and Surgeons and NewYork-Presbyterian, New York, NY, USA., Tomassoni L; Department of Systems Biology, Columbia University Irving Medical Center, New York, NY, USA., Zandkarimi F; Department of Chemistry, Columbia University, New York, USA., Chio IIC; Institute for Cancer Genetics, Department of Genetics and Development, Columbia University Irving Medical Center, New York, NY, USA., Canoll PD; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY USA., Bruce JN; Department of Neurological Surgery, Columbia University Irving Medical Center, New York, NY USA., Feldstein NA; Department of Neurological Surgery, Columbia University Irving Medical Center, New York, NY USA., Gartrell RD; Department of Oncology, Division of Pediatric Oncology, Johns Hopkins University School of Medicine, Baltimore, MD USA.; Department of Pediatrics, Columbia University Irving Medical Center, New York, NY, USA., Cheng S; Department of Radiation Oncology, Columbia University Vagelos College of Physicians and Surgeons and NewYork-Presbyterian, New York, NY, USA.; Herbert Irving Comprehensive Cancer Center, Columbia University Vagelos College of Physicians and Surgeons and NewYork-Presbyterian, New York, NY USA., Garvin JH; Department of Pediatrics, Columbia University Irving Medical Center, New York, NY, USA., Zacharoulis S; Department of Pediatrics, Columbia University Irving Medical Center, New York, NY, USA., Wechsler-Reya RJ; Herbert Irving Comprehensive Cancer Center, Columbia University Vagelos College of Physicians and Surgeons and NewYork-Presbyterian, New York, NY USA.; Department of Neurology, Columbia University Irving Medical Center, New York, NY, USA., Pavisic J; Department of Pediatrics, Columbia University Irving Medical Center, New York, NY, USA., Califano A; Herbert Irving Comprehensive Cancer Center, Columbia University Vagelos College of Physicians and Surgeons and NewYork-Presbyterian, New York, NY USA.; Department of Systems Biology, Columbia University Irving Medical Center, New York, NY, USA.; Department of Biomedical Informatics, Columbia University, New York, NY USA.; Chan Zuckerberg Biohub New York, New York, NY USA.; Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY USA.; Department of Medicine, Columbia University, New York, NY USA., Zhang Z; Institute for Cancer Genetics, Department of Genetics and Development, Columbia University Irving Medical Center, New York, NY, USA., Wu CC; Department of Biomedical Engineering and Mechanics, Virginia Tech School of Medicine, Roanoke, VA.

Publikováno v: Neuro-oncology [Neuro Oncol] 2024 Oct 12. Date of Electronic Publication: 2024 Oct 12.

Distinct Nrf2 Signaling Thresholds Mediate Lung Tumor Initiation and Progression.

Autor: DeBlasi JM; Department of Metabolism & Physiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.; Cancer Biology PhD Program, University of South Florida, Tampa, Florida., Falzone A; Department of Metabolism & Physiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida., Caldwell S; Department of Metabolism & Physiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida., Prieto-Farigua N; Department of Metabolism & Physiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida., Prigge JR; Microbiology & Cell Biology Department, Montana State University, Bozeman, Montana., Schmidt EE; Microbiology & Cell Biology Department, Montana State University, Bozeman, Montana., Chio IIC; Department of Genetics and Development, Institute for Cancer Genetics, Columbia University Irving Medical Center, New York, New York.; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, New York., Karreth FA; Department of Molecular Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida., DeNicola GM; Department of Metabolism & Physiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.

Publikováno v: Cancer research [Cancer Res] 2023 Jun 15; Vol. 83 (12), pp. 1953-1967.

Inactivation of Notch4 Attenuated Pancreatic Tumorigenesis in Mice.

Autor: Saeki K; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, New York.; Department of Pathology & Cell Biology, Columbia University Irving Medical Center, New York, New York., Qiu W; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, New York.; Department of Pathology & Cell Biology, Columbia University Irving Medical Center, New York, New York., Friedman RA; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, New York.; Department of Biomedical Informatics, Columbia University Irving Medical Center, New York, New York., Pan S; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, New York.; Department of Biostatistics, Columbia University Irving Medical Center, New York, New York., Lu J; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, New York.; Institute for Cancer Genetics, Columbia University Irving Medical Center, New York, New York., Ichimiya S; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, New York.; Institute for Cancer Genetics, Columbia University Irving Medical Center, New York, New York., Chio IIC; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, New York.; Institute for Cancer Genetics, Columbia University Irving Medical Center, New York, New York., Shawber CJ; Deparments of Obstetrics and Gynecology and Surgery, Columbia University Irving Medical Center, New York, New York., Kitajewski J; Department of Physiology and Biophysics, University of Illinois Cancer Center, University of Illinois Chicago, Chicago, Illinois., Hu J; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, New York.; Department of Biostatistics, Columbia University Irving Medical Center, New York, New York., Su GH; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, New York.; Department of Pathology & Cell Biology, Columbia University Irving Medical Center, New York, New York.

Publikováno v: Cancer research communications [Cancer Res Commun] 2022 Dec 12; Vol. 2 (12), pp. 1601-1616. Date of Electronic Publication: 2022 Dec 12 (Print Publication: 2022).

Methionine oxidation activates pyruvate kinase M2 to promote pancreatic cancer metastasis.

Autor: He D; Department of Chemistry, University of California, Berkeley, Berkeley, CA 94720, USA., Feng H; Institute for Cancer Genetics, Department of Genetics and Development, Columbia University Irving Medical Center, New York, NY 10032, USA; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY 10032, USA., Sundberg B; Institute for Cancer Genetics, Department of Genetics and Development, Columbia University Irving Medical Center, New York, NY 10032, USA; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY 10032, USA., Yang J; Institute for Cancer Genetics, Department of Genetics and Development, Columbia University Irving Medical Center, New York, NY 10032, USA; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY 10032, USA., Powers J; Institute for Cancer Genetics, Department of Genetics and Development, Columbia University Irving Medical Center, New York, NY 10032, USA; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY 10032, USA., Christian AH; Department of Chemistry, University of California, Berkeley, Berkeley, CA 94720, USA., Wilkinson JE; University of Michigan Medical School, Ann Arbor, MI 48109, USA., Monnin C; Metabolomics Innovation Resource, Rosalind and Morris Goodman Cancer Institute, McGill University, Montreal, QC H3A 1A3, Canada., Avizonis D; Metabolomics Innovation Resource, Rosalind and Morris Goodman Cancer Institute, McGill University, Montreal, QC H3A 1A3, Canada., Thomas CJ; Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD 20850, USA; Lymphoid Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA., Friedman RA; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY 10032, USA; Department of Biomedical Informatics, Columbia University Irving Medical Center, New York, NY 10032, USA., Kluger MD; Division of Gastrointestinal & Endocrine Surgery, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA., Hollingsworth MA; Eppley Institute for Research in Cancer and Allied Diseases, Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE 68198, USA., Grandgenett PM; Eppley Institute for Research in Cancer and Allied Diseases, Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE 68198, USA., Klute KA; Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE 68198, USA., Toste FD; Department of Chemistry, University of California, Berkeley, Berkeley, CA 94720, USA., Chang CJ; Department of Chemistry, University of California, Berkeley, Berkeley, CA 94720, USA; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA. Electronic address: chrischang@berkeley.edu., Chio IIC; Institute for Cancer Genetics, Department of Genetics and Development, Columbia University Irving Medical Center, New York, NY 10032, USA; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY 10032, USA. Electronic address: christine.chio@columbia.edu.

Publikováno v: Molecular cell [Mol Cell] 2022 Aug 18; Vol. 82 (16), pp. 3045-3060.e11. Date of Electronic Publication: 2022 Jun 24.