Zobrazeno 1 - 10
of 145
pro vyhledávání: '"Chinnaswamy, Jagannath"'
Autor:
Alexis R. Steinmetz, Morgan Pierce, Alberto Martini, Come Tholomier, Ganiraju Manyam, Yan Chen, Akshay Sood, Jonathan J. Duplisea, Burles A. Johnson, Bogdan A. Czerniak, Byron H. Lee, Chinnaswamy Jagannath, Seppo Yla-Herttuala, Nigel R. Parker, David J. McConkey, Colin P. Dinney, Sharada Mokkapati
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionNadofaragene firadenovec (Ad-IFNα/Syn3) is now approved for BCG-unresponsive bladder cancer (BLCA). IFNα is a pleiotropic cytokine that causes direct tumor cell killing via TRAIL-mediated apoptosis, angiogenesis inhibition, and activati
Externí odkaz:
https://doaj.org/article/63a622d2fe494a5898ec7dc003c1d01b
Autor:
Abhishek Mishra, Arshad Khan, Vipul Kumar Singh, Emily Glyde, Sankaralingam Saikolappan, Omar Garnica, Kishore Das, Raja Veerapandian, Subramanian Dhandayuthapani, Chinnaswamy Jagannath
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Tuberculosis (TB) remains a significant global health challenge, with approximately 1.5 million deaths per year. The Bacillus Calmette-Guérin (BCG) vaccine against TB is used in infants but shows variable protection. Here, we introduce a novel appro
Externí odkaz:
https://doaj.org/article/50fe6729025b4050bf607384e5c03d58
Autor:
José Alejandro Bohórquez, Sitaramaraju Adduri, Danish Ansari, Sahana John, Jon Florence, Omoyeni Adejare, Gaurav Singh, Nagarjun V. Konduru, Chinnaswamy Jagannath, Guohua Yi
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
BackgroundTuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), continues to be a major public health problem worldwide. The human immunodeficiency virus (HIV) is another equally important life-threatening pathogen. HIV infection decreases C
Externí odkaz:
https://doaj.org/article/752bd6e80b5c40a1b4f45441275f46a8
Publikováno v:
Vaccines, Vol 12, Iss 8, p 901 (2024)
Coinfection with Mycobacterium tuberculosis (Mtb) and the human immunodeficiency virus (HIV) is a significant public health concern. Individuals infected with Mtb who acquire HIV are approximately 16 times more likely to develop active tuberculosis.
Externí odkaz:
https://doaj.org/article/15dd51a202db421dbb6f5880072185b4
Autor:
Ekramy E. Sayedahmed, Marcelo Valdemir Araújo, Taiana Tainá Silva-Pereira, Shubhada K. Chothe, Ahmed Elkashif, Marwa Alhashimi, Wen-Chien Wang, Andrea P. Santos, Meera Surendran Nair, Abhinay Gontu, Ruth Nissly, Antônio Francisco de Souza Filho, Mariana Silva Tavares, Marina Caçador Ayupe, Caio Loureiro Salgado, Érika Donizetti de Oliveira Candido, Danielle Bruna Leal Oliveira, Edison Luiz Durigon, Marcos Bryan Heinemann, Denise Morais da Fonseca, Chinnaswamy Jagannath, Ana Marcia Sá Guimarães, Suresh V. Kuchipudi, Suresh K. Mittal
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 30, Iss , Pp 194-207 (2023)
Because of continual generation of new variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), it is critical to design the next generation of vaccines to combat the threat posed by SARS-CoV-2 variants. We developed human adenovirus
Externí odkaz:
https://doaj.org/article/4546dbaeda5b4dfa95545d2dbef95e54
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Arginine and tryptophan are pivotal in orchestrating cytokine-driven macrophage polarization and immune activation. Specifically, interferon-gamma (IFN-γ) stimulates inducible nitric oxide synthase (iNOS) expression), leading to the conversion of ar
Externí odkaz:
https://doaj.org/article/fd907904c788402097905712695a29a8
Publikováno v:
Vaccines, Vol 12, Iss 5, p 530 (2024)
Tuberculosis (TB), a chronic infectious disease affecting humans, causes over 1.3 million deaths per year throughout the world. The current preventive vaccine BCG provides protection against childhood TB, but it fails to protect against pulmonary TB.
Externí odkaz:
https://doaj.org/article/bafa08b414094cab88bc47a4892dcf2d
Autor:
Ekramy E. Sayedahmed, Nelly O. Elshafie, Andrea P. dos Santos, Chinnaswamy Jagannath, Suryaprakash Sambhara, Suresh K. Mittal
Publikováno v:
Vaccines, Vol 12, Iss 2, p 157 (2024)
The nucleoprotein (NP) is a vital target for the heterosubtypic immunity of CD8+ cytotoxic T lymphocytes (CTLs) due to its conservation among influenza virus subtypes. To further enhance the T cell immunity of NP, autophagy-inducing peptide C5 (AIP-C
Externí odkaz:
https://doaj.org/article/5db201f60a3540b78f779c4abf24a943
Autor:
Arshad Khan, Kangling Zhang, Vipul K. Singh, Abhishek Mishra, Priyanka Kachroo, Tian Bing, Jong Hak Won, Arunmani Mani, Ramesha Papanna, Lovepreet K. Mann, Eder Ledezma-Campos, Genesis Aguillon-Duran, David H. Canaday, Sunil A. David, Blanca I. Restrepo, Nhung Nguyen Viet, Ha Phan, Edward A. Graviss, James M. Musser, Deepak Kaushal, Marie Claire Gauduin, Chinnaswamy Jagannath
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-19 (2022)
Khan et al. use human blood and a macaque model of tuberculosis (TB) to assess whether macrophage heterogeneity contributes to TB immunity. They demonstrate that human macrophages show unique patterns of gene expression that enable differential contr
Externí odkaz:
https://doaj.org/article/8cf06a1a4f1b42998d5b3586157a23de
Autor:
Kangling Zhang, Mark L. Sowers, Ellie I. Cherryhomes, Vipul K. Singh, Abhishek Mishra, Blanca I. Restrepo, Arshad Khan, Chinnaswamy Jagannath
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Macrophages are the preeminent phagocytic cells which control multiple infections. Tuberculosis a leading cause of death in mankind and the causative organism Mycobacterium tuberculosis (MTB) infects and persists in macrophages. Macrophages use react
Externí odkaz:
https://doaj.org/article/430127cf2afd426fafd65b8cca7fff42