In vivo activation of the hypoxia-targeted cytotoxin AQ4N in human tumor xenografts

Autor: Williams, K. J., Albertella, M. R., Fitzpatrick, B., Loadman, P. M., Shnyder, S. D., Chinje, E. C., Telfer, B. A., Dunk, C. R., Harris, P. A., Stratford, I. J.

AQ4N (banoxantrone) is a prodrug that, under hypoxic conditions, is enzymatically converted to a cytotoxic DNA-binding agent, AQ4. Incorporation of AQ4N into conventional chemoradiation protocols therefore targets both oxygenated and hypoxic regions

Externí odkaz: http://hdl.handle.net/10454/6236

NADPH:cytochrome c (P450) reductase activates tirapazamine (SR4233) to restore hypoxic and oxic cytotoxicity in an aerobic resistant derivative of the A549 lung cancer cell line.

Autor: Saunders, M P, Patterson, A V, Chinje, E C, Harris, A L, Stratford, I J

Publikováno v: British Journal of Cancer; 2/1/2000, Vol. 82 Issue 3, p651-656, 6p

Development and validation of a spectrophotometric assay for measuring the activity of NADH: cytochrome b5 reductase in human tumour cells.

Autor: Barham, HM, Inglis, R, Chinje, EC, Stratford, IJ, Barham, H M, Chinje, E C, Stratford, I J

Publikováno v: British Journal of Cancer; Oct1996, Vol. 74 Issue 8, p1188-1193, 6p

S-2-Amino-5-azolylpentanoic acids related to L-ornithine as inhibitors of the isoforms of nitric oxide a synthase (NOS)

Autor: Ulhaq, S., Chinje, E. C., Naylor, M. A., Jaffar, M., Stratford, I. J., Threadgill, M. D.

Publikováno v: Bioorganic & Medicinal Chemistry; 1998, Vol. 6 Issue: 11 p2139-2150, 12p

17beta-Oestradiol treatment modulates nitric oxide synthase activity in MDA231 tumour with implications on growth and radiation response.

Autor: Chinje EC; Experimental Oncology Group, School of Pharmacy and Pharmaceutical Sciences, University of Manchester, Oxford Road, Manchester M13 9PL, UK. edwin.chinje@man.ac.uk, Williams KJ, Telfer BA, Wood PJ, van der Kogel AJ, Stratford IJ

Publikováno v: British journal of cancer [Br J Cancer] 2002 Jan 07; Vol. 86 (1), pp. 136-42.