Escape from recognition of SARS-CoV-2 variant spike epitopes but overall preservation of T cell immunity.

Autor: Riou C; Wellcome Centre for Infectious Diseases Research in Africa, University of Cape Town, Observatory 7925, South Africa.; Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory 7925, South Africa.; Division of Medical Virology, Department of Pathology, University of Cape Town, Observatory 7925, South Africa., Keeton R; Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory 7925, South Africa.; Division of Medical Virology, Department of Pathology, University of Cape Town, Observatory 7925, South Africa., Moyo-Gwete T; National Institute for Communicable Diseases of the National Health Laboratory Services, Johannesburg, South Africa.; MRC Antibody Immunity Research Unit, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa., Hermanus T; National Institute for Communicable Diseases of the National Health Laboratory Services, Johannesburg, South Africa.; MRC Antibody Immunity Research Unit, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa., Kgagudi P; National Institute for Communicable Diseases of the National Health Laboratory Services, Johannesburg, South Africa.; MRC Antibody Immunity Research Unit, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa., Baguma R; Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory 7925, South Africa.; Division of Medical Virology, Department of Pathology, University of Cape Town, Observatory 7925, South Africa., Valley-Omar Z; Division of Medical Virology, Department of Pathology, University of Cape Town, Observatory 7925, South Africa., Smith M; Division of Medical Virology, Department of Pathology, University of Cape Town, Observatory 7925, South Africa., Tegally H; KwaZulu-Natal Research Innovation and Sequencing Platform, Durban, South Africa., Doolabh D; Division of Medical Virology, Department of Pathology, University of Cape Town, Observatory 7925, South Africa., Iranzadeh A; Division of Medical Virology, Department of Pathology, University of Cape Town, Observatory 7925, South Africa., Tyers L; Division of Medical Virology, Department of Pathology, University of Cape Town, Observatory 7925, South Africa., Mutavhatsindi H; Wellcome Centre for Infectious Diseases Research in Africa, University of Cape Town, Observatory 7925, South Africa.; Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory 7925, South Africa., Tincho MB; Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory 7925, South Africa.; Division of Medical Virology, Department of Pathology, University of Cape Town, Observatory 7925, South Africa., Benede N; Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory 7925, South Africa.; Division of Medical Virology, Department of Pathology, University of Cape Town, Observatory 7925, South Africa., Marais G; Division of Medical Virology, Department of Pathology, University of Cape Town, Observatory 7925, South Africa.; Groote Schuur Hospital Medical Virology Laboratory of the National Health Laboratory Service, Observatory 7925, South Africa., Chinhoyi LR; Department of Medicine, University of Cape Town and Groote Schuur Hospital, Observatory 7925, South Africa.; Hatter Institute for Cardiovascular Research in Africa, Faculty of Health Sciences, University of Cape Town, Observatory 7925, South Africa., Mennen M; Department of Medicine, University of Cape Town and Groote Schuur Hospital, Observatory 7925, South Africa.; Hatter Institute for Cardiovascular Research in Africa, Faculty of Health Sciences, University of Cape Town, Observatory 7925, South Africa., Skelem S; Department of Medicine, University of Cape Town and Groote Schuur Hospital, Observatory 7925, South Africa.; Hatter Institute for Cardiovascular Research in Africa, Faculty of Health Sciences, University of Cape Town, Observatory 7925, South Africa., du Bruyn E; Wellcome Centre for Infectious Diseases Research in Africa, University of Cape Town, Observatory 7925, South Africa.; Department of Medicine, University of Cape Town and Groote Schuur Hospital, Observatory 7925, South Africa., Stek C; Wellcome Centre for Infectious Diseases Research in Africa, University of Cape Town, Observatory 7925, South Africa.; Department of Medicine, University of Cape Town and Groote Schuur Hospital, Observatory 7925, South Africa.; Department of Infectious Diseases, Imperial College London, London W12 0NN, UK., de Oliveira T; KwaZulu-Natal Research Innovation and Sequencing Platform, Durban, South Africa., Williamson C; Wellcome Centre for Infectious Diseases Research in Africa, University of Cape Town, Observatory 7925, South Africa.; Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory 7925, South Africa.; Division of Medical Virology, Department of Pathology, University of Cape Town, Observatory 7925, South Africa., Moore PL; National Institute for Communicable Diseases of the National Health Laboratory Services, Johannesburg, South Africa.; MRC Antibody Immunity Research Unit, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa., Wilkinson RJ; Wellcome Centre for Infectious Diseases Research in Africa, University of Cape Town, Observatory 7925, South Africa.; Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory 7925, South Africa.; Department of Medicine, University of Cape Town and Groote Schuur Hospital, Observatory 7925, South Africa.; Department of Infectious Diseases, Imperial College London, London W12 0NN, UK.; The Francis Crick Institute, London NW1 1AT, UK., Ntusi NAB; Wellcome Centre for Infectious Diseases Research in Africa, University of Cape Town, Observatory 7925, South Africa.; Department of Medicine, University of Cape Town and Groote Schuur Hospital, Observatory 7925, South Africa.; Hatter Institute for Cardiovascular Research in Africa, Faculty of Health Sciences, University of Cape Town, Observatory 7925, South Africa., Burgers WA; Wellcome Centre for Infectious Diseases Research in Africa, University of Cape Town, Observatory 7925, South Africa.; Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory 7925, South Africa.; Division of Medical Virology, Department of Pathology, University of Cape Town, Observatory 7925, South Africa.

Publikováno v: Science translational medicine [Sci Transl Med] 2022 Feb 09; Vol. 14 (631), pp. eabj6824. Date of Electronic Publication: 2022 Feb 09.

SARS-CoV-2 501Y.V2 (B.1.351) elicits cross-reactive neutralizing antibodies.

Autor: Moyo-Gwete T; National Institute for Communicable Diseases of the National Health Laboratory Service, Johannesburg, South Africa.; Antibody Immunity Research Unit, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa., Madzivhandila M; National Institute for Communicable Diseases of the National Health Laboratory Service, Johannesburg, South Africa., Makhado Z; National Institute for Communicable Diseases of the National Health Laboratory Service, Johannesburg, South Africa., Ayres F; National Institute for Communicable Diseases of the National Health Laboratory Service, Johannesburg, South Africa., Mhlanga D; National Institute for Communicable Diseases of the National Health Laboratory Service, Johannesburg, South Africa., Oosthuysen B; National Institute for Communicable Diseases of the National Health Laboratory Service, Johannesburg, South Africa., Lambson BE; National Institute for Communicable Diseases of the National Health Laboratory Service, Johannesburg, South Africa.; Antibody Immunity Research Unit, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa., Kgagudi P; National Institute for Communicable Diseases of the National Health Laboratory Service, Johannesburg, South Africa., Tegally H; KwaZulu-Natal Research Innovation and Sequencing Platform (KRISP), Department of Laboratory Medicine & Medical Sciences, University of KwaZulu-Natal, Durban, South Africa., Iranzadeh A; Institute of Infectious Disease and Molecular Medicine, Division of Medical Virology, Department of Pathology, University of Cape Town, Cape Town, South Africa., Doolabh D; Institute of Infectious Disease and Molecular Medicine, Division of Medical Virology, Department of Pathology, University of Cape Town, Cape Town, South Africa., Tyers L; Institute of Infectious Disease and Molecular Medicine, Division of Medical Virology, Department of Pathology, University of Cape Town, Cape Town, South Africa., Chinhoyi LR; Wellcome Centre for Infectious Diseases Research in Africa, University of Cape Town, Cape Town, South Africa.; Division of Cardiology, Department of Medicine, University of Cape Town and Groote Schuur Hospital, Cape Town, South Africa.; Hatter Institute for Cardiovascular Research in Africa, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa., Mennen M; Wellcome Centre for Infectious Diseases Research in Africa, University of Cape Town, Cape Town, South Africa.; Division of Cardiology, Department of Medicine, University of Cape Town and Groote Schuur Hospital, Cape Town, South Africa.; Hatter Institute for Cardiovascular Research in Africa, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa., Skelem S; Wellcome Centre for Infectious Diseases Research in Africa, University of Cape Town, Cape Town, South Africa.; Division of Cardiology, Department of Medicine, University of Cape Town and Groote Schuur Hospital, Cape Town, South Africa.; Hatter Institute for Cardiovascular Research in Africa, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa., Marais G; Institute of Infectious Disease and Molecular Medicine, Division of Medical Virology, Department of Pathology, University of Cape Town, Cape Town, South Africa.; National Health Laboratory Services, Groote Schuur Hospital, Cape Town, South Africa., Wibmer CK; National Institute for Communicable Diseases of the National Health Laboratory Service, Johannesburg, South Africa., Bhiman JN; National Institute for Communicable Diseases of the National Health Laboratory Service, Johannesburg, South Africa.; Department of Virology, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa., Ueckermann V; Division for Infectious Diseases, Department of Internal Medicine, Steve Biko Academic Hospital and University of Pretoria, Pretoria, South Africa., Rossouw T; Department of Immunology, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa., Boswell M; Division for Infectious Diseases, Department of Internal Medicine, Steve Biko Academic Hospital and University of Pretoria, Pretoria, South Africa., de Oliveira T; KwaZulu-Natal Research Innovation and Sequencing Platform (KRISP), Department of Laboratory Medicine & Medical Sciences, University of KwaZulu-Natal, Durban, South Africa.; Centre for the AIDS Programme of Research in South Africa (CAPRISA), Durban, South Africa.; Department of Global Health, University of Washington, Seattle, USA., Williamson C; Institute of Infectious Disease and Molecular Medicine, Division of Medical Virology, Department of Pathology, University of Cape Town, Cape Town, South Africa.; Wellcome Centre for Infectious Diseases Research in Africa, University of Cape Town, Cape Town, South Africa.; National Health Laboratory Services, Groote Schuur Hospital, Cape Town, South Africa., Burgers WA; Institute of Infectious Disease and Molecular Medicine, Division of Medical Virology, Department of Pathology, University of Cape Town, Cape Town, South Africa.; Wellcome Centre for Infectious Diseases Research in Africa, University of Cape Town, Cape Town, South Africa., Ntusi N; Wellcome Centre for Infectious Diseases Research in Africa, University of Cape Town, Cape Town, South Africa.; Division of Cardiology, Department of Medicine, University of Cape Town and Groote Schuur Hospital, Cape Town, South Africa.; Hatter Institute for Cardiovascular Research in Africa, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa., Morris L; National Institute for Communicable Diseases of the National Health Laboratory Service, Johannesburg, South Africa.; Antibody Immunity Research Unit, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.; Centre for the AIDS Programme of Research in South Africa (CAPRISA), Durban, South Africa., Moore PL; National Institute for Communicable Diseases of the National Health Laboratory Service, Johannesburg, South Africa.; Antibody Immunity Research Unit, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.; Centre for the AIDS Programme of Research in South Africa (CAPRISA), Durban, South Africa.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2021 Mar 11. Date of Electronic Publication: 2021 Mar 11.