Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Ching-Shin Huang"'
Publikováno v:
mAbs, Vol 16, Iss 1 (2024)
Natural killer (NK) cells are effector cells of the innate immune system that distinguish between healthy and abnormal cells through activating and inhibitory receptor signaling. NKG2D, a homodimeric activating receptor expressed on NK cells, recogni
Externí odkaz:
https://doaj.org/article/226c08477f9a4a3aac1f4727a2361136
Autor:
Hanzhi Zhang, Ching-Shin Huang, Xinchao Yu, Jonas Lee, Amit Vaish, Qing Chen, Mingyue Zhou, Zhulun Wang, Xiaoshan Min
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-9 (2021)
Zhang et al. present the cryo-EM structure of ATP-binding cassette transporters ABCG5/G8 in complex with the Fab fragments from two monoclonal antibodies at 3.3 Å resolution. This study provides structural insights into the transport cycle and poten
Externí odkaz:
https://doaj.org/article/89adae28264f40d7b90ec8bef59c63f3
Autor:
Fernando Garces, Christopher Mohr, Li Zhang, Ching-Shin Huang, Qing Chen, Chadwick King, Cen Xu, Zhulun Wang
Publikováno v:
Cell Reports, Vol 30, Iss 6, Pp 1714-1723.e6 (2020)
Summary: Calcitonin-gene-related peptide (CGRP) plays a key role in migraine pathophysiology. Aimovig (erenumab; erenumab-aooe in the United States) is the only US Food and Drug Administration (FDA)-approved monoclonal antibody (mAb) therapy against
Externí odkaz:
https://doaj.org/article/14b9f6be07614e2c913c5e20ce95fd7a
Autor:
Xiaoshan Min, Junming Yie, Jinghong Wang, Ben C. Chung, Ching-Shin Huang, Haoda Xu, Jie Yang, Liying Deng, Joanne Lin, Qing Chen, Christina M. Abbott, Caroline Gundel, Stephen A. Thibault, Tina Meng, Darren L. Bates, David J. Lloyd, Murielle M. Véniant, Zhulun Wang
Publikováno v:
mAbs, Vol 12, Iss 1 (2020)
Glucose-dependent insulinotropic polypeptide (GIP) is an incretin hormone involved in regulating glucose and lipid metabolism. GIP receptor (GIPR) antagonism is believed to offer therapeutic potential for various metabolic diseases. Pharmacological i
Externí odkaz:
https://doaj.org/article/968f0a3d32354e02bad2c843bdc326da
Autor:
Ching-Shin Huang, 黃慶鑫
96
Heterotrimeric G-protein system serves many important roles in signal transduction and physiologies of mammalian and yeast. Upon ligand activation, G-protein coupled receptor (GPCR) could lead to a conformational change in Gα subunit and tri
Heterotrimeric G-protein system serves many important roles in signal transduction and physiologies of mammalian and yeast. Upon ligand activation, G-protein coupled receptor (GPCR) could lead to a conformational change in Gα subunit and tri
Externí odkaz:
http://ndltd.ncl.edu.tw/handle/06300639542651996331
Autor:
Amit Vaish, Zhulun Wang, Xiaoshan Min, Ching-Shin Huang, Jonas Lee, Xinchao Yu, Mingyue Zhou, Qing Chen, Hanzhi Zhang
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-9 (2021)
Communications Biology
Communications Biology
The heterodimer of ATP-binding cassette transporter ABCG5 and ABCG8 mediates the excretion of sterols from liver and intestine, playing a critical role in cholesterol homeostasis. Here, we present the cryo-EM structure of ABCG5/G8 in complex with the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ebc2c4ebf287433b9a8c309ff1e954f
https://doaj.org/article/89adae28264f40d7b90ec8bef59c63f3
https://doaj.org/article/89adae28264f40d7b90ec8bef59c63f3
Autor:
Wah Chiu, Preston Fordstrom, Zhulun Wang, Soung Hun Roh, Xiaoshan Min, Xinchao Yu, Kaylee Choi, Mingyue Zhou, Ben C. Chung, Ching-Shin Huang
Publikováno v:
Science Advances
Details of intestinal sterol absorption and inhibition by cholesterol-lowering drug are uncovered in new protein structures.
The intestinal absorption of cholesterol is mediated by a multipass membrane protein, Niemann-Pick C1-Like 1 (NPC1L1), t
The intestinal absorption of cholesterol is mediated by a multipass membrane protein, Niemann-Pick C1-Like 1 (NPC1L1), t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1e6c9fd61eb2984c17ff9f774d73ed3
https://pubmed.ncbi.nlm.nih.gov/32596471
https://pubmed.ncbi.nlm.nih.gov/32596471
Autor:
Ching-Shin Huang, Caroline Gundel, Ben C. Chung, Joanne Lin, Qing Chen, Liying Deng, Darren L. Bates, Zhulun Wang, Jinghong Wang, Jie Yang, Murielle M. Véniant, David Lloyd, Xiaoshan Min, Stephen A. Thibault, Haoda Xu, Christina Abbott, Tina Meng, Junming Yie
Publikováno v:
mAbs
Glucose-dependent insulinotropic polypeptide (GIP) is an incretin hormone involved in regulating glucose and lipid metabolism. GIP receptor (GIPR) antagonism is believed to offer therapeutic potential for various metabolic diseases. Pharmacological i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5ec036e73660230e011396dc0673377
https://doi.org/10.1080/19420862.2019.1710047
https://doi.org/10.1080/19420862.2019.1710047
Publikováno v:
Nature
Huang, C-S, Pedersen, B P & Stokes, D 2017, ' Crystal structure of the potassium-importing KdpFABC membrane complex ', Nature, vol. 546, no. 7660, pp. 681-685 . https://doi.org/10.1038/nature22970
Huang, C-S, Pedersen, B P & Stokes, D 2017, ' Crystal structure of the potassium-importing KdpFABC membrane complex ', Nature, vol. 546, no. 7660, pp. 681-685 . https://doi.org/10.1038/nature22970
Cellular potassium import systems play a fundamental role in osmoregulation, pH homeostasis and membrane potential in all domains of life. In bacteria, the kdp operon encodes a four subunit potassium pump that maintains intracellular homeostasis as w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed0a80d9a4cbf2f31ee0ce35cc3b69c2
https://doi.org/10.1038/nature22970
https://doi.org/10.1038/nature22970
Autor:
Ching-Shin Huang1, Xinchao Yu1, Fordstrom, Preston2, Kaylee Choi1, Chung, Ben C.1, Soung-Hun Roh3, Wah Chiu3,4, Mingyue Zhou2, Xiaoshan Min1,5, Zhulun Wang1 zwang@amgen.com
Publikováno v:
Science Advances. 6/17/2020, Vol. 6 Issue 25, p1-11. 11p.