Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Ching-Ni Njauw"'
Publikováno v:
JID Innovations, Vol 4, Iss 3, Pp 100266- (2024)
Acral and mucosal melanomas are often driven by sequence variants in the KIT receptor tyrosine kinase, with nearly 40% harboring alterations in the KIT locus. Despite advances in the knowledge of KIT-mutated melanomas, little is known about the molec
Externí odkaz:
https://doaj.org/article/4d33b7b87030482486f967ed5c11b9b7
Autor:
Adriana Sanna, Bengt Phung, Shamik Mitra, Martin Lauss, Jiyeon Choi, Tongwu Zhang, Ching-Ni Njauw, Eugenia Cordero, Katja Harbst, Frida Rosengren, Rita Cabrita, Iva Johansson, Karolin Isaksson, Christian Ingvar, Ana Carneiro, Kevin Brown, Hensin Tsao, My Andersson, Kristian Pietras, Göran Jönsson
Publikováno v:
JCI Insight, Vol 7, Iss 19 (2022)
Cellular stress contributes to the capacity of melanoma cells to undergo phenotype switching into highly migratory and drug-tolerant dedifferentiated states. Such dedifferentiated melanoma cell states are marked by loss of melanocyte-specific gene ex
Externí odkaz:
https://doaj.org/article/37d81ad9a39246c69b971323fad1eabb
Autor:
Fani Karagianni, Ching-Ni Njauw, Katerina P. Kypreou, Aravela Stergiopoulou, Michaela Plaka, Dorothea Polydorou, Vasiliki Chasapi, Leontios Pappas, Ioannis A. Stratigos, Gregory Champsas, Peter Panagiotou, Helen Gogas, Evangelos Evangelou, Hensin Tsao, Alexander J. Stratigos, Irene Stefanaki
Publikováno v:
Acta Dermato-Venereologica, Vol 98, Iss 9, Pp 862-866 (2018)
Approximately 5–10% of melanoma cases occur in a familial context. CDKN2A/CDK4 were the first high-penetrance melanoma genes identified. The aims of this study were to evaluate CDKN2A/CDK4 variants in Greek familial melanoma patients and to correla
Externí odkaz:
https://doaj.org/article/a4a434b325354ada9b03910e61a6bf55
One of the physiologic consequences of excessive UV radiation (UVR) exposure is apoptosis. This critical response serves to eliminate genetically injured cells and arises, in part, from activation of DNA damage and p53 signaling. Other contributory p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7db2d9c5ba5f23f29b5bddf99bf68c76
https://doi.org/10.1158/0008-5472.c.6497306
https://doi.org/10.1158/0008-5472.c.6497306
Supplementary Figure 1 from EphA2 Is an Essential Mediator of UV Radiation–Induced Apoptosis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38d38017a36f92f7d31cf91d8d4528e3
https://doi.org/10.1158/0008-5472.22374035.v1
https://doi.org/10.1158/0008-5472.22374035.v1
Autor:
Samantha M. Guhan, Mykyta Artomov, Alexander J. Stratigos, Hensin Tsao, Kristen M. Shannon, Shelley R. McCormick, Ching-Ni Njauw, Leif W. Ellisen
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-5 (2020)
Scientific Reports
Scientific Reports
The MITF(E318K) variant confers moderate risk for cutaneous melanoma. While there are small studies suggesting that this risk is associated with other malignancies (e.g. renal cell carcinoma), little is known about the role of this variant in specify
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30717cae8ec89f85738ea95ee4397256
http://link.springer.com/article/10.1038/s41598-020-74237-z
http://link.springer.com/article/10.1038/s41598-020-74237-z
Autor:
Adriana, Sanna, Bengt, Phung, Shamik, Mitra, Martin, Lauss, Jiyeon, Choi, Tongwu, Zhang, Ching-Ni, Njauw, Eugenia, Cordero, Katja, Harbst, Frida, Rosengren, Rita, Cabrita, Iva, Johansson, Karolin, Isaksson, Christian, Ingvar, Ana, Carneiro, Kevin, Brown, Hensin, Tsao, My, Andersson, Kristian, Pietras, Göran, Jönsson
Publikováno v:
JCI insight. 7(19)
Cellular stress contributes to the capacity of melanoma cells to undergo phenotype switching into highly migratory and drug-tolerant dedifferentiated states. Such dedifferentiated melanoma cell states are marked by loss of melanocyte-specific gene ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f93663c2e9e4e0a07e424c491ce61f7c
https://pubmed.ncbi.nlm.nih.gov/36040798
https://pubmed.ncbi.nlm.nih.gov/36040798
Oncogenic KIT Induces Replication Stress and Confers Cell Cycle Checkpoint Vulnerability in Melanoma
Autor:
Raj Kumar, Lee Zou, Zhenyu Ji, Ching-Ni Njauw, Antoine Simoneau, Duc Daniel M. Pham, Hensin Tsao, Keith T. Flaherty
Publikováno v:
Journal of Investigative Dermatology. 142:1413-1424.e6
Acral and mucosal melanomas (AMM’s) arise from sun-protected sites, disproportionately impact darker-skinned individuals and exact a higher mortality than common types of cutaneous melanoma. Genetically, AMM’s harbor more alterations of KIT compa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::822dfb8f4832712f1dbcdd1040d72153
https://doi.org/10.1016/j.jid.2021.07.188
https://doi.org/10.1016/j.jid.2021.07.188
Autor:
Hensin Tsao, Nathanael S. Gray, Tinghu Zhang, Ching-Ni Njauw, Brian J. Abraham, Camilla L. Christensen, Kwok-Kin Wong, Raj Kumar, Michael Taylor, Philip Eliades, Zhenyu Ji, Benchun Miao, Nicholas Kwiatkowski, David Miller, Richard A. Young
Publikováno v:
PMC
Cutaneous melanoma is an aggressive tumor that accounts for most skin cancer deaths. Among the physiological barriers against therapeutic success is a strong survival program driven by genes such as MITF that specify melanocyte identity, a phenomenon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc5d8c40dced4686b9266e3ef2eb4098
https://doi.org/10.1016/j.jid.2017.09.056
https://doi.org/10.1016/j.jid.2017.09.056
Autor:
Vasiliki Chasapi, Katerina P. Kypreou, Peter Panagiotou, I. Stefanaki, Evangelos Evangelou, Fani Karagianni, Dorothea Polydorou, Helen Gogas, Alexander J. Stratigos, Gregory Champsas, Hensin Tsao, Michaela Plaka, Ioannis A. Stratigos, Leontios Pappas, Aravela Stergiopoulou, Ching-Ni Njauw
Publikováno v:
Acta Dermato-Venereologica, Vol 98, Iss 9, Pp 862-866 (2018)
Acta dermato-venereologica
Acta dermato-venereologica
Approximately 5–10% of melanoma cases occur in a familial context. CDKN2A/CDK4 were the first high- penetrance melanoma genes identified. The aims of this study were to evaluate CDKN2A/CDK4 variants in Greek familial melanoma patients and to correl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::708d1e3e51d321cb22a6f59fdb12dca4
https://doi.org/10.2340/00015555-2969
https://doi.org/10.2340/00015555-2969