Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Ching-Hsuen Chu"'
Autor:
Yanling Ma, Hong Cai, Julia Smith, Ching-Hsuen Chu, Stephen E. Mercer, Stephanie Boehm, Ivar Mcdonald, Bradley Zinker, Dong Cheng
Publikováno v:
Journal of Lipid Research, Vol 65, Iss 3, Pp 100514- (2024)
Human genetic evidence suggests a protective role of loss-of-function variants in 17-beta hydroxysteroid dehydrogenase 13 (HSD17B13) for liver fibrotic diseases. Although there is limited preclinical experimental data on Hsd17b13 antisense oligonucle
Externí odkaz:
https://doaj.org/article/961d2ae3e8bd48ffa4f295bbb6a4f902
Autor:
Joelle M. Onorato, Ching-Hsuen Chu, Zhengping Ma, Lisa M. Kopcho, Hannguang J. Chao, R.Michael Lawrence, Dong Cheng
Publikováno v:
Journal of Lipid Research, Vol 56, Iss 3, Pp 747-753 (2015)
To demonstrate monoacylglycerol acyltransferase 2 (MGAT2)-mediated enzyme activity in a cellular context, cells of the murine secretin tumor cell-1 line of enteroendocrine origin were used to construct human MGAT2-expressing recombinant cell lines. L
Externí odkaz:
https://doaj.org/article/d164256204b843b0ad2be9f52d8848a8
Publikováno v:
Journal of Lipid Research, Vol 50, Iss 10, Pp 2131-2135 (2009)
ATP citrate lyase (ACL) is a cytosolic enzyme that catalyzes the synthesis of acetyl-CoA and oxaloacetate using citrate, CoA, and ATP as substrates and Mg2+ as a necessary cofactor. The ACL-dependent synthesis of acetyl-CoA is thought to be an essent
Externí odkaz:
https://doaj.org/article/cc03d4a67f0b42a48ee23df9ffa99763
Autor:
Haris Jamil, Ching-Hsuen Chu, John K. Dickson, Jr., Ying Chen, Mujing Yan, Scott A. Biller, Richard E. Gregg, John R. Wetterau, David A. Gordon
Publikováno v:
Journal of Lipid Research, Vol 39, Iss 7, Pp 1448-1454 (1998)
The microsomal triglyceride transfer protein (MTP) is a heterodimeric lipid transfer protein that is required for the assembly and secretion of apolipoprotein B (apoB)-containing lipoproteins. A key unresolved question is whether the MTP-mediated ste
Externí odkaz:
https://doaj.org/article/16c45b43aabf402ba2850fe8686267a1
Autor:
Brian J. Murphy, Daniel Smith, Julia Sapuppo, Giridhar S. Tirucherai, Lawrence J. Kennedy, Ching-Hsuen Chu, Anthony V. Azzara, Shiwei Tao, Glenn D. Rosen, Subramaniam Krishnananthan, Jun Li, Victor R. Guarino, Lisa Burns, Joseph R. Taylor, Milinda Ziegler, Lakshmi Sivaraman, Bruce A. Ellsworth, Selvakumar Kumaravel, Hao Zhang, Tao Wang, Jun Shi, Atsu Apedo, Dhanusu Suresh, Kathy Mosure, Gerry Everlof, David A. Gordon, Lisa Zhang, Michael Gill, Chen-Pin Hung, Jianqing Li, Peter T. W. Cheng, Robert F. Kaltenbach, Sutjano Jusuf, Ying Wang, Stephanie Boehm, Mary Ellen Cvijic, Matthew G. Soars, Chi Shing Sum, Yan Shi, Jeffrey A. Robl, Reddigunta Ramesh Babu, Bradley A. Zinker, Yanou Yang, Stephen S. Kalinowski, Carrie Xu, Steven J. Walker, Sarah C. Traeger, Rebekah Heiry, Kimberley A. Lentz, Qian Ruan
Publikováno v:
Journal of Medicinal Chemistry. 64:15549-15581
The oxycyclohexyl acid BMS-986278 (33) is a potent lysophosphatidic acid receptor 1 (LPA1) antagonist, with a human LPA1 Kb of 6.9 nM. The structure-activity relationship (SAR) studies starting from the LPA1 antagonist clinical compound BMS-986020 (1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c00ce908946d21bafba2486eb2e08c90
https://doi.org/10.1021/acs.jmedchem.1c01256
https://doi.org/10.1021/acs.jmedchem.1c01256
Autor:
Shu Chang, Anthony V. Azzara, Yi-Xin Li, Marta Dabros, James Kempson, Reshma Panemangelor, Huji Turdi, Kimberly A. Foster, William J. Keim, Jean M. Whaley, Jeffrey A. Robl, Fang Moore, Luping Chen, Mary Jane Cullen, Xiaoping Hou, Atsu Apedo, R. Michael Lawrence, Arvind Mathur, David G. Harden, Wei Meng, Kevin O'Malley, Mary Ann Pelleymounter, Hannguang Chao, Pratik Devasthale, Jon J. Hangeland, Zhengping Ma, Dauh-Rurng Wu, Robert Paul Brigance, Guohua Zhao, Lynn M. Abell, Qi Gao, Susan Harvey, Lisa M. Kopcho, Dong Cheng, Elizabeth A. Dierks, Ching-Hsuen Chu, Suzanne Rooney, Xiang-Yang Ye, Saleem Ahmad, Wei Wang
Publikováno v:
Journal of Medicinal Chemistry. 64:14773-14792
MGAT2 inhibition is a potential therapeutic approach for the treatment of metabolic disorders. High-throughput screening of the BMS internal compound collection identified the aryl dihydropyridinone compound 1 (hMGAT2 IC50 = 175 nM) as a hit. Compoun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40e90999a2854f1a395c0459b5cd876d
https://doi.org/10.1021/acs.jmedchem.1c01356
https://doi.org/10.1021/acs.jmedchem.1c01356
Autor:
Dong Cheng, Bradley A. Zinker, Yi Luo, Petia Shipkova, Claudia H. De Oliveira, Gopal Krishna, Elizabeth A. Brown, Stephanie L. Boehm, Giridhar S. Tirucherai, Huidong Gu, Zhengping Ma, Ching-Hsuen Chu, Joelle M. Onorato, Lisa M. Kopcho, Ron Ammar, Julia Smith, Pratik Devasthale, R. Michael Lawrence, Steven A. Stryker, Elizabeth A. Dierks, Anthony V. Azzara, Leon Carayannopoulos, Edgar D. Charles, Kimberley A. Lentz, David A. Gordon
Publikováno v:
Cell metabolism. 34(11)
Monoacylglycerol acyltransferase 2 (MGAT2) is an important enzyme highly expressed in the human small intestine and liver for the regulation of triglyceride absorption and homeostasis. We report that treatment with BMS-963272, a potent and selective
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::394387e9e73eae85eafb5bf7ab1908f8
https://pubmed.ncbi.nlm.nih.gov/36323235
https://pubmed.ncbi.nlm.nih.gov/36323235
Autor:
Peter T W, Cheng, Robert F, Kaltenbach, Hao, Zhang, Jun, Shi, Shiwei, Tao, Jun, Li, Lawrence J, Kennedy, Steven J, Walker, Yan, Shi, Ying, Wang, Suresh, Dhanusu, Ramesh, Reddigunta, Selvakumar, Kumaravel, Sutjano, Jusuf, Daniel, Smith, Subramaniam, Krishnananthan, Jianqing, Li, Tao, Wang, Rebekah, Heiry, Chi Shing, Sum, Stephen S, Kalinowski, Chen-Pin, Hung, Ching-Hsuen, Chu, Anthony V, Azzara, Milinda, Ziegler, Lisa, Burns, Bradley A, Zinker, Stephanie, Boehm, Joseph, Taylor, Julia, Sapuppo, Kathy, Mosure, Gerry, Everlof, Victor, Guarino, Lisa, Zhang, Yanou, Yang, Qian, Ruan, Carrie, Xu, Atsu, Apedo, Sarah C, Traeger, Mary Ellen, Cvijic, Kimberley A, Lentz, Giridhar, Tirucherai, Lakshmi, Sivaraman, Jeffrey, Robl, Bruce A, Ellsworth, Glenn, Rosen, David A, Gordon, Matthew G, Soars, Michael, Gill, Brian J, Murphy
Publikováno v:
Journal of medicinal chemistry. 64(21)
The oxycyclohexyl acid BMS-986278 (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::80069106f38ceb56aa2828cf9bc68357
https://pubmed.ncbi.nlm.nih.gov/34709814
https://pubmed.ncbi.nlm.nih.gov/34709814
Autor:
Michael Gill, Matt Soars, Robert F. Kaltenbach, Mosure Kathy, Peter T. W. Cheng, Anthony V. Azzara, Stephen S. Kalinowski, Shiwei Tao, Chen-Pin Hung, Larry Kennedy, Yan Shi, Lisa Burns, Julia Sapuppo, Tao Wang, David A. Gordon, Roble Jeffrey, Cvijic Mary-Ellen, Hao Zhang, Ching-Hsuen Chu, Reddigunta Ramesh Babu, Jun Shi, Bruce A. Ellsworth, Jun Li, Bradley A. Zinker, Brian J. Murphy, Dhanusu Suresh, Joseph R. Taylor, Ying Wang, Chi-Shing Sum, Ziegler Milinda, Rebekah Heiry, Steve Walker, Stephanie Boehm
Publikováno v:
Idiopathic interstitial pneumonias.
Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive and fatal fibrosing lung disease with limited approved treatment options. The bioactive lysophospholipid lysophosphatidic acid (LPA) and the LPA1 receptor have been implicated in the etiol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8b54aea41cff0b233b97a0c88ca4d9ae
https://doi.org/10.1183/13993003.congress-2019.pa5383
https://doi.org/10.1183/13993003.congress-2019.pa5383
Autor:
Huji Turdi, Hannguang Chao, Hangeland, Jon J., Ahmad, Saleem, Wei Meng, Brigance, Robert, Guohua Zhao, Wei Wang, Fang Moore, Xiang-Yang Ye, Mathur, Arvind, Xiaoping Hou, Kempson, James, Dauh-Rurng Wu, Yi-Xin Li, Azzara, Anthony V., Zhengping Ma, Ching-Hsuen Chu, Luping Chen, Cullen, Mary Jane
Publikováno v:
Journal of Medicinal Chemistry; 10/14/2021, Vol. 64 Issue 19, p14773-14792, 20p