Zobrazeno 1 - 10
of 205
pro vyhledávání: '"Ching-Chuan Kuo"'
Autor:
Chih-Peng Lin, Shu-Hui Wu, Tzu-Yin Lin, Chia-Hui Chu, Leu-Wei Lo, Ching-Chuan Kuo, Jang-Yang Chang, Szu-Chun Hsu, Bor-Sheng Ko, Ming Yao, Jong-Kai Hsiao, Shih-Wei Wang, Dong-Ming Huang
Publikováno v:
Pharmacological Research, Vol 197, Iss , Pp 106945- (2023)
Multidrug resistance (MDR) is a major challenge in cancer chemotherapy. Nanoparticles as drug delivery systems (DDSs) show promise for MDR cancer therapy. However, current DDSs require sophisticated design and construction based on xenogeneic nanomat
Externí odkaz:
https://doaj.org/article/86f572430e7749389f8fa9beb3b0a6e4
Autor:
Chi-I Chang, Cheng-Chih Hsieh, Yung-Shung Wein, Ching-Chuan Kuo, Chi-Yen Chang, Jrhau Lung, Jong-Yuh Cherng, Po-Chen Chu, Jang-Yang Chang, Yueh-Hsiung Kuo
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 7, p 6386 (2023)
Salvinal is a natural lignan isolated from the roots of Salvia mitorrhiza Bunge (Danshen). Previous studies have demonstrated its anti-proliferative activity in both drug-sensitive and -resistant cancer cell lines, with IC50 values ranging from 4–1
Externí odkaz:
https://doaj.org/article/467288e91d924e40a9e0b10ff248ce42
Autor:
Shine-Gwo Shiah, Jenn-Ren Hsiao, Hsiao-Ju Chang, Yuan-Ming Hsu, Guan-Hsun Wu, Hsuan-Yu Peng, Sung-Tau Chou, Ching-Chuan Kuo, Jang-Yang Chang
Publikováno v:
Journal of Biomedical Science, Vol 27, Iss 1, Pp 1-13 (2020)
Abstract Background Epigenetic silencing of retinoic acid (RA) signaling-related genes have been linked with the pathogenesis and clinical outcome in oral squamous cell carcinoma (OSCC) carcinogenesis. However, the precise mechanisms underlying the a
Externí odkaz:
https://doaj.org/article/8eb2b9f459944aa48d0ec169c427c2d6
Publikováno v:
Frontiers in Nutrition, Vol 8 (2022)
Sleep disturbances have been the hallmark of the recent coronavirus disease 2019 pandemic. Studies have shown that once sleep is disrupted, it can lead to psychological and physical health issues which can, in turn, disrupt circadian rhythm and induc
Externí odkaz:
https://doaj.org/article/edbf2dcb2ee6467c92b2a2f61993c36a
Autor:
Wen‐Jui Lee, Li‐Ching Chen, Juo‐Han Lin, Tzu‐Chun Cheng, Ching‐Chuan Kuo, Chih‐Hsiung Wu, Hui‐Wen Chang, Shih‐Hsin Tu, Yuan‐Soon Ho
Publikováno v:
Cancer Medicine, Vol 8, Iss 10, Pp 4821-4835 (2019)
Abstract Neuroblastoma is the second most common pediatric malignancy and has a high rate of spontaneous remission. Uncovering the mechanisms underlying neuroblastoma cell differentiation is critical for therapeutic purposes. A neuroblastoma cell lin
Externí odkaz:
https://doaj.org/article/7db11a9223b44eb8bb62dcd816d0ed33
Publikováno v:
Journal of Biomedical Science, Vol 25, Iss 1, Pp 1-12 (2018)
Abstract Background Tumor hypoxia-induced epithelial–mesenchymal transition (EMT) is critical in promoting cancer metastasis. We recently discovered a novel microtubule inhibitor, MPT0B098, that employs a novel antitumor mechanism. It destabilizes
Externí odkaz:
https://doaj.org/article/e22f493fa73243738f5e15e66b8f8542
Autor:
Wen-Jui Lee, Shih-Hsin Tu, Tzu-Chun Cheng, Juo-Han Lin, Ming-Thau Sheu, Ching-Chuan Kuo, Chun A. Changou, Chih-Hsiung Wu, Hui-Wen Chang, Hang-Lung Chang, Li-Ching Chen, Yuan-Soon Ho
Publikováno v:
Molecules, Vol 26, Iss 21, p 6548 (2021)
The microenvironment for tumor growth and developing metastasis should be essential. This study demonstrated that the hyaluronic acid synthase 3 (HAS3) protein and its enzymatic product hyaluronic acid (HA) encompassed in the subcutaneous extracellul
Externí odkaz:
https://doaj.org/article/75da9fb660f848f9a5d1943f57c0c831
Autor:
Hsuan-Yu Peng, Yun-Ching Cheng, Yuan-Ming Hsu, Guan-Hsun Wu, Ching-Chuan Kuo, Jing-Ping Liou, Jang-Yang Chang, Shiow-Lian Catherine Jin, Shine-Gwo Shiah
Publikováno v:
PLoS ONE, Vol 11, Iss 7, p e0158440 (2016)
Microtubule inhibitors have been shown to inhibit Janus kinase 2/signal transducer and activator of transcription 3 (JAK2/STAT3) signal transduction pathway in various cancer cells. However, little is known of the mechanism by which the microtubule i
Externí odkaz:
https://doaj.org/article/ad73fcf91c054cb490d13e16a9687a2c
Publikováno v:
Journal of Traditional and Complementary Medicine, Vol 2, Iss 4, Pp 267-275 (2012)
Adlay (薏苡 yì yĭ; “soft-shelled job’s tears”, the seeds of Coix lachryma-jobi L. var. ma-yuen Stapf) is a grass crop that has long been used in traditional Chinese medicine (TCM) and as a nourishing food in China for the treatment of warts
Externí odkaz:
https://doaj.org/article/4434147ced824d0aabb61b963082ff57
Autor:
Jing-Ping Liou, Jang-Yang Chang, Chih-Ying Nien, Cheng-Chih Hsieh, Chi-Yen Chang, Ching-Chuan Kuo, Hsueh-Yun Lee
Publikováno v:
Molecules, Vol 16, Iss 3, Pp 2274-2284 (2011)
A series of 2-aroyl and 2-aryl-5,6,7-trimethoxyquinoline and 4-aroyl-6,7,8-trimethoxyquinoline combretastatin analogs were synthesized and evaluated for their potential anticancer activity. The 4-aroylquinoline 11 inhibited the growth of the human ca
Externí odkaz:
https://doaj.org/article/c5757fd4e4e44640934a2f3f6505fcb8