Metabolic dysregulation in Huntington's disease: Neuronal and glial perspectives

Autor: Ching-Pang Chang, Ching-Wen Wu, Yijuang Chern

Publikováno v: Neurobiology of Disease, Vol 201, Iss , Pp 106672- (2024)

Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder caused by a mutant huntingtin protein with an abnormal CAG/polyQ expansion in the N-terminus of HTT exon 1. HD is characterized by progressive neurodegeneration and metabol

Externí odkaz: https://doaj.org/article/aea99a4fd40047b0b5414155e0f1db5f

Equilibrative nucleoside transporter 1 inhibition rescues energy dysfunction and pathology in a model of tauopathy

Autor: Ching-Pang Chang, Ya-Gin Chang, Pei-Yun Chuang, Thi Ngoc Anh Nguyen, Kuo-Chen Wu, Fang-Yi Chou, Sin-Jhong Cheng, Hui-Mei Chen, Lee-Way Jin, Kevin Carvalho, Vincent Huin, Luc Buée, Yung-Feng Liao, Chun-Jung Lin, David Blum, Yijuang Chern

Publikováno v: Acta Neuropathologica Communications, Vol 9, Iss 1, Pp 1-18 (2021)

Abstract Tau pathology is instrumental in the gradual loss of neuronal functions and cognitive decline in tauopathies, including Alzheimer’s disease (AD). Earlier reports showed that adenosine metabolism is abnormal in the brain of AD patients whil

Externí odkaz: https://doaj.org/article/8e4c10b7573a4385835d8307e2cb35af

Equilibrative nucleoside transporter ENT1 as a biomarker of Huntington disease

Autor: Xavier Guitart, Jordi Bonaventura, William Rea, Marco Orrú, Lucrezia Cellai, Ilaria Dettori, Felicita Pedata, Marc Brugarolas, Antonio Cortés, Vicent Casadó, Ching-Pang Chang, Manikandan Narayanan, Yijuang Chern, Sergi Ferré

Publikováno v: Neurobiology of Disease, Vol 96, Iss , Pp 47-53 (2016)

The initial goal of this study was to investigate alterations in adenosine A2A receptor (A2AR) density or function in a rat model of Huntington disease (HD) with reported insensitivity to an A2AR antagonist. Unsuspected negative results led to the hy

Externí odkaz: https://doaj.org/article/5f0fc91ff1fc465fa5369d2dd9737a1f

Equilibrative nucleoside transporter 1 inhibition rescues energy dysfunction and pathology in a model of tauopathy

Autor: Ya Gin Chang, Luc Buée, Kuo Chen Wu, Ching Pang Chang, Fang Yi Chou, Vincent Huin, Lee-Way Jin, Sin-Jhong Cheng, David Blum, Yung-Feng Liao, Pei Yun Chuang, Thi Ngoc Anh Nguyen, Hui Mei Chen, Chun-Jung Lin, Yijuang Chern, Kevin Carvalho

Publikováno v: Acta Neuropathologica Communications
Acta Neuropathologica Communications, 2021, 9 (1), pp.112. ⟨10.1186/s40478-021-01213-7⟩
Acta Neuropathologica Communications, Vol 9, Iss 1, Pp 1-18 (2021)
Acta Neuropathologica Communications, BioMed Central part of Springer Science, 2021, 9 (1), pp.112. ⟨10.1186/s40478-021-01213-7⟩
Acta neuropathologica communications, vol 9, iss 1

Tau pathology is instrumental in the gradual loss of neuronal functions and cognitive decline in tauopathies, including Alzheimer’s disease (AD). Earlier reports showed that adenosine metabolism is abnormal in the brain of AD patients while consequ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6f0ba8cb343743295eb8124c0c2fa3c
https://www.hal.inserm.fr/inserm-03366697/file/s40478-021-01213-7.pdf

Longitudinal evaluation of an N-ethyl-N-nitrosourea-created murine model with normal pressure hydrocephalus.

Autor: Ming-Jen Lee, Ching-Pang Chang, Yi-Hsin Lee, Yi-Chih Wu, Hsu-Wen Tseng, Yu-Ying Tung, Min-Tzu Wu, Yen-Hui Chen, Lu-Ting Kuo, Dennis Stephenson, Shuen-Iu Hung, Jer-Yuarn Wu, Chen Chang, Yuan-Tsong Chen, Yijuang Chern

Publikováno v: PLoS ONE, Vol 4, Iss 11, p e7868 (2009)

BACKGROUND:Normal-pressure hydrocephalus (NPH) is a neurodegenerative disorder that usually occurs late in adult life. Clinically, the cardinal features include gait disturbances, urinary incontinence, and cognitive decline. METHODOLOGY/PRINCIPAL FIN

Externí odkaz: https://doaj.org/article/0ffa8da6c72d4d118d450ac150f08ff3