Zobrazeno 1 - 10
of 256
pro vyhledávání: '"Ching Kang Chen"'
Autor:
Mritunjay Pandey, Jian-Hua Zhang, Poorni R. Adikaram, Claire Kittock, Nicole Lue, Adam Awe, Katherine Degner, Nirmal Jacob, Jenna Staples, Rachel Thomas, Allison B. Kohnen, Sundar Ganesan, Juraj Kabat, Ching-Kang Chen, William F. Simonds
Publikováno v:
JCI Insight, Vol 8, Iss 13 (2023)
Mechanical, thermal, and chemical pain sensation is conveyed by primary nociceptors, a subset of sensory afferent neurons. The intracellular regulation of the primary nociceptive signal is an area of active study. We report here the discovery of a G
Externí odkaz:
https://doaj.org/article/04100bd6616e4b5b8c76a81a09c61a61
Publikováno v:
Cells, Vol 11, Iss 14, p 2203 (2022)
The retina, the accessible part of the central nervous system, has served as a model system to study the relationship between energy utilization and metabolite supply. When the metabolite supply cannot match the energy demand, retinal neurons are at
Externí odkaz:
https://doaj.org/article/970c061b7b5041e783173fb83f17340c
Autor:
Takae Kiyama, Ching-Kang Chen, Steven W Wang, Ping Pan, Zhenlin Ju, Jing Wang, Shinako Takada, William H Klein, Chai-An Mao
Publikováno v:
Molecular Neurodegeneration, Vol 13, Iss 1, Pp 1-23 (2018)
Abstract Background Mitochondrial dysfunction has been implicated in the pathologies of a number of retinal degenerative diseases in both the outer and inner retina. In the outer retina, photoreceptors are particularly vulnerable to mutations affecti
Externí odkaz:
https://doaj.org/article/86e23958dde9462c9e095325aaa44ae2
Autor:
Takae Kiyama, Ye Long, Ching-Kang Chen, Christopher M. Whitaker, Allison Shay, Hongyu Wu, Tudor C. Badea, Amir Mohsenin, Jan Parker-Thornburg, William H. Klein, Stephen L. Mills, Stephen C. Massey, Chai-An Mao
Publikováno v:
Cell Reports, Vol 27, Iss 3, Pp 900-915.e5 (2019)
Summary: In the mouse retina, more than 30 retinal ganglion cell (RGC) subtypes have been classified based on a combined metric of morphological and functional characteristics. RGCs arise from a common pool of retinal progenitor cells during embryoni
Externí odkaz:
https://doaj.org/article/9c325aa44e9d4b08967f1de839af1fac
Autor:
Tudor C. Badea, Ching-Kang Chen, Nicole Weber, Ping Pan, Christopher M. Whitaker, Chai-An Mao, Stephen C. Massey, Takae Kiyama
Publikováno v:
J Comp Neurol
The mammalian retina contains more than 40 retinal ganglion cell (RGC) subtypes based on their unique morphologies, functions, and molecular profiles. Among them, intrinsically photosensitive RGCs (ipRGCs) are the first specified RGC type emerging fr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6cf93b171245b582a2499b5c629d2aa
https://doi.org/10.1002/cne.25208
https://doi.org/10.1002/cne.25208
Autor:
Christopher M Tracy, Alexander V Kolesnikov, Devon R Blake, Ching-Kang Chen, Wolfgang Baehr, Vladimir J Kefalov, Barry M Willardson
Publikováno v:
PLoS ONE, Vol 10, Iss 2, p e0117129 (2015)
G protein β subunits (Gβ) play essential roles in phototransduction as part of G protein βγ (Gβγ) and regulator of G protein signaling 9 (RGS9)-Gβ5 heterodimers. Both are obligate dimers that rely on the cytosolic chaperone CCT and its co-chap
Externí odkaz:
https://doaj.org/article/41dd7572ce18406d9175fa0dc4ac2c64
Autor:
William H. Klein, Allison Shay, Amir Mohsenin, Christopher M. Whitaker, Stephen L. Mills, Takae Kiyama, Chai An Mao, Ye Long, Tudor C. Badea, Stephen C. Massey, Jan Parker-Thornburg, Hongyu Wu, Ching-Kang Chen
Publikováno v:
Cell Reports, Vol 27, Iss 3, Pp 900-915.e5 (2019)
Summary: In the mouse retina, more than 30 retinal ganglion cell (RGC) subtypes have been classified based on a combined metric of morphological and functional characteristics. RGCs arise from a common pool of retinal progenitor cells during embryoni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a9a9631921906669b88ac3cdecf557e
http://www.sciencedirect.com/science/article/pii/S2211124719304164
http://www.sciencedirect.com/science/article/pii/S2211124719304164
Publikováno v:
The Journal of Neuroscience. 39:3041-3056
The mammalian visual system operates over an extended range of ambient light levels by switching between rod and cone photoreceptors. Rod-driven vision is sluggish, highly sensitive, and operates in dim or scotopic lights, whereas cone-driven vision
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ded0242a6d59ae2ba98a05fa3c544822
https://doi.org/10.1523/jneurosci.1404-18.2019
https://doi.org/10.1523/jneurosci.1404-18.2019
Autor:
J Christopher Octeau, Joseph M Schrader, Ikuo Masuho, Meenakshi Sharma, Christopher Aiudi, Ching-Kang Chen, Abraham Kovoor, Jeremy Celver
Publikováno v:
PLoS ONE, Vol 9, Iss 8, p e105791 (2014)
G beta 5 (Gbeta5, Gβ5) is a unique G protein β subunit that is thought to be expressed as an obligate heterodimer with R7 regulator of G protein signaling (RGS) proteins instead of with G gamma (Gγ) subunits. We found that D2-dopamine receptor (D2
Externí odkaz:
https://doaj.org/article/57c65d263ef84be59288b515d21880a6