Using a fed-batch culture process to enhance rAAV production in baculovirus/insect system and development of asthma therapy with rAAV-mediated AMCase shRNA

Autor: Ching Jen Yang, 楊靜仁

97
Recombinant adeno-associated virus (rAAV) is one of the most promising vectors for human gene therapy. However, the production systems that are currently available have a limited capacity and cannot provide sufficient quantities of rAAV for p

Externí odkaz: http://ndltd.ncl.edu.tw/handle/23561730640106449524

Resveratrol or Its Metabolites Modulate TNF-α And IL-13 Mediated Changes In IL-8 and Acidic Mammalian Chitinase In Cultured Human Pulmonary Artery Endothelial Cells

Autor: Joseph M. Wu, Ching-Jen Yang, Tze-chen Hsieh, Susan C. Olson

Publikováno v: jcvm. 1:1-5

Chronic inflammation is implicated in the etiology of Cardiovascular Disease (CVD), the leading cause of death among men and women. Accordingly, the discovery of inflammation biomarkers, identification of agents with anti-inflammation properties, and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fe4cbf74049f6a0dfcb7502bc7b31c5e
https://doi.org/10.17303/jcvm.2013.1.202

The Correlation between Chitin and Acidic Mammalian Chitinase in Animal Models of Allergic Asthma

Autor: Ming-Ling Kuo, Horng-Heng Juang, Chao-Lin Liu, Jeen-Kuan Chen, Meng-Hua Lee, Chia-Jen Wu, Ya-Shan Chen, Hui-Shan Chen, Yih-Shiou Hwang, Ching-Jen Yang, Chia-Rui Shen

Publikováno v: International Journal of Molecular Sciences, Vol 16, Iss 11, Pp 27371-27377 (2015)
International Journal of Molecular Sciences
International Journal of Molecular Sciences; Volume 16; Issue 11; Pages: 27371-27377

Asthma is the result of chronic inflammation of the airways which subsequently results in airway hyper-responsiveness and airflow obstruction. It has been shown that an elicited expression of acidic mammalian chitinase (AMCase) may be involved in the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::502df765c36cc76e40e28bba97e9859a
http://www.mdpi.com/1422-0067/16/11/26033

HBV maintains electrostatic homeostasis by modulating negative charges from phosphoserine and encapsidated nucleic acids

Autor: Chiaho Shih, Chih-Hsu Chang, Chiayn Chiang, Tien-Hua Chu, Pei-Yi Su, Chih-Yin Lee, Fan-Mei Tang, Ching-Jen Yang

Publikováno v: Scientific Reports

Capsid assembly and stability of hepatitis B virus (HBV) core protein (HBc) particles depend on balanced electrostatic interactions between encapsidated nucleic acids and an arginine-rich domain (ARD) of HBc in the capsid interior. Arginine-deficient

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1562fecf963e15818bd89db48e4239d3

Colloid Chitin Azure Is a Dispersible, Low-Cost Substrate for Chitinase Measurements in a Sensitive, Fast, Reproducible Assay

Autor: Ching-Jen Yang, Chen Yu-Sheng, Chia-Rui Shen, Chao-Lin Liu, Jeen-Kuan Chen

Publikováno v: SLAS Discovery. 15:213-217

Chitin and its derivatives are widely used as biomedical materials because of their versatility and biocompatibility. Chitinases are enzymes that produce chito-oligosaccharides from chitin. The assay of chitinase activity is difficult because few app

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd386ea7f1150c2c77e754e03d892604
https://doi.org/10.1177/1087057109355057