Gene Set Enrichment Analsyes Identify Pathways Involved in Genetic Risk for Diabetic Retinopathy

Autor: Jie Jin Wang, Robert P. Igo, Barry I. Freedman, Jerome I. Rotter, Kathyrn P. Burdon, Alan D. Penman, Albert V. Smith, Xiaohui Li, Jamie E. Craig, Paul Mitchell, Brian L. Yaspan, Mary Frances Cotch, John M. Rouhana, Ayellet V. Segrè, Barbara E.K. Klein, Ashley Li, Richard A. Jensen, Gayatri Susarla, Lynn K. Stanwyck, Sudha K. Iyengar, Maggie C.Y. Ng, Ching J. Chen, Kent D. Taylor, Donald W. Bowden, Lucia Sobrin, Tien Yin Wong, Emily Y. Chew, Sharon G. Adler, Samuela Pollack, Jane Z. Kuo

Publikováno v: Am J Ophthalmol

To identify functionally related genes associated with diabetic retinopathy (DR) risk using gene set enrichment analyses applied to genome-wide association study meta-analyses.MethodsWe analyzed DR GWAS meta-analyses performed on 3246 Europeans and 2

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86ad6e49bb0953ea357e7561f1b3b1a6
https://doi.org/10.1016/j.ajo.2021.06.014

Multiethnic Genome-Wide Association Study of Diabetic Retinopathy Using Liability Threshold Modeling of Duration of Diabetes and Glycemic Control

Autor: Mark I. McCarthy, Weihua Meng, Brian L. Yaspan, M Imamura, Mark W. Christiansen, Niina Sandholm, Yii-Der Ida Chen, Sharon G. Adler, Lucia Sobrin, Craig L. Hanis, Valeriya Lyssenko, Shiro Maeda, Yang Hai, Paul Mitchell, Roberta McKean-Cowdin, Xiuqing Guo, John R. Sedor, David S. Siscovick, Sudha K. Iyengar, Heather Hancock, Jane Z. Kuo, Barbara E.K. Klein, David-Alexandre Tregouet, Elisabet Agardh, Kent D. Taylor, Andrew D. Morris, S. Mohsen Hosseini, Andrew D. Paterson, I-Te Lee, Wayne Huey-Herng Sheu, Emma Ahlqvist, Kathryn P. Burdon, Leif Groop, Ayellet V. Segrè, Samy Hadjadj, Samaneh Davoudi, Lynn K. Stanwyck, Emily Y. Chew, Xiaohui Li, Michael A. Grassi, Jie Jin Wang, Samuela Pollack, Albert V. Smith, Kyu Hyung Park, Michiaki Kubo, Mary Frances Cotch, Yucheng Jia, Ching J. Chen, Colin N. A. Palmer, Helen M. Colhoun, Alan D. Penman, R. Varma, Per-Henrik Groop, Tien Yin Wong, Barry I. Freedman, Eli Ipp, Alex S. F. Doney, Gavin Tan, Ronald Klein, Kaanan P. Shah, Jamie E Craig, Donald W. Bowden, Jerome I. Rotter, Robert P. Igo, Darryl Nousome, Ching-Yu Cheng, Michel Marre, Maggie C.Y. Ng, Latchezar Dimitrov, Jeeyun Ahn, Atsushi Takahashi, Richard A. Jensen, Aaron Leong, Jihye Kim, Iiro Toppila, Elizabeth J. Rossin, Alkes L. Price

Publikováno v: Diabetes
2018, ' Multiethnic Genome-wide Association Study of Diabetic Retinopathy using Liability Threshold Modeling of Duration of Diabetes and Glycemic Control ', Diabetes . https://doi.org/10.2337/db18-0567

To identify genetic variants associated with diabetic retinopathy (DR), we performed a large multiethnic genome-wide association study. Discovery included eight European cohorts (n = 3,246) and seven African American cohorts (n = 2,611). We meta-anal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3c06ced2484457b77b42e102a713972
https://doi.org/10.2337/db18-0567

Genetically Determined Plasma Lipid Levels and Risk of Diabetic Retinopathy: A Mendelian Randomization Study

Autor: Paul Mitchell, Alan D. Penman, Vilmundur Gudnason, Xiuqing Guo, Mark W. Christiansen, Yii-Der Ida Chen, Yang Hai, Alfred Tau Liang Gan, Yi-Jen Hung, Barbara E.K. Klein, Wen-Ling Liao, Richard A. Jensen, Wen-Jane Lee, Bruce M. Psaty, Kathryn P. Burdon, Ching J. Chen, Albert V. Smith, Lynn K. Stanwyck, Yong He Chong, Jie Jin Wang, Qiao Fan, Yucheng Jia, Georgia Kaidonis, Craig L. Hanis, Ronald Klein, Gavin Tan, Jihye Kim, Jane Kuo, Eli Ipp, Ching-Yu Cheng, Samuela Pollack, Fuu Jen Tsai, Tien Yin Wong, Gerald Liew, Mary Frances Cotch, Alkes L. Price, Jerome I. Rotter, Xiaohui Li, Kevin Sandow, Yu-Chuen Huang, Lucia Sobrin, Jamie E Craig, Heather Hancock

Publikováno v: Diabetes

Results from observational studies examining dyslipidemia as a risk factor for diabetic retinopathy (DR) have been inconsistent. We evaluated the causal relationship between plasma lipids and DR using a Mendelian randomization approach. We pooled gen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62dcef438dd7e42b843492cf1ca085fa
https://doi.org/10.2337/db17-0398

Surgical management of diabetic tractional retinal detachments

Autor: Ching J. Chen, Kathleen A. Regan, Siva S R Iyer, Jordan M. Burnham

Publikováno v: Survey of ophthalmology. 64(6)

Tractional retinal detachment is an end-stage form of diabetic retinopathy that occurs when contractile forces in the vitreous and neovascular tissue lead to the detachment of the neurosensory retina. We review the literature related to the managemen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f87cdf251980f58d73e74274515a7ad5
https://pubmed.ncbi.nlm.nih.gov/31077688

Gene Set Enrichment Analsyes Identify Pathways Involved in Genetic Risk for Diabetic Retinopathy.

Autor: SOBRIN, LUCIA, SUSARLA, GAYATRI, STANWYCK, LYNN, ROUHANA, JOHN M., LI, ASHLEY, POLLACK, SAMUELA, IGO JR, ROBERT P., JENSEN, RICHARD A., XIAOHUI LI, NG, MAGGIE C. Y., SMITH, ALBERT V., KUO, JANE Z., TAYLOR, KENT D., FREEDMAN, BARRY I., BOWDEN, DONALD W., PENMAN, ALAN, CHING J. CHEN, CRAIG, JAMIE E., ADLER, SHARON G., CHEW, EMILY Y.

Publikováno v: Transactions of the American Ophthalmological Society; 2021, Vol. 119, p111-123, 13p