Výsledky vyhledávání - "Ching Chun Yang"

Akademický článek

Hepatitis B virus virion secretion is a CRM1-spike-mediated late event

Autor: Pei-Yi Su, Shin-Chwen Bruce Yen, Ching-Chun Yang, Chih-Hsu Chang, Wen-Chang Lin, Chiaho Shih

Publikováno v: Journal of Biomedical Science, Vol 29, Iss 1, Pp 1-16 (2022)

Abstract Background Hepatitis B virus (HBV) is a major human pathogen worldwide. To date, there is no curative treatment for chronic hepatitis B. The mechanism of virion secretion remains to be investigated. Previously, we found that nuclear export o

Externí odkaz: https://doaj.org/article/2d36e4a7b21d4504afc6b382465902c8

Zobrazit plný text záznamu

Plný text ve formátu HTML

Akademický článek

PPARγ activation improves the microenvironment of perivascular adipose tissue and attenuates aortic stiffening in obesity

Autor: Ju-Yi Chen, Yi-Pin Wu, Chih-Yi Li, Huei-Fen Jheng, Ling-Zhen Kao, Ching-Chun Yang, Sy-Ying Leu, I-Chia Lien, Wen-Tsan Weng, Haw-Chih Tai, Yu-Wei Chiou, Ming-Jer Tang, Pei-Jane Tsai, Yau-Sheng Tsai

Publikováno v: Journal of Biomedical Science, Vol 28, Iss 1, Pp 1-19 (2021)

Abstract Background Obesity-related cardiovascular risk, end points, and mortality are strongly related to arterial stiffening. Current therapeutic approaches for arterial stiffening are not focused on direct targeting within the vessel. Perivascular

Externí odkaz: https://doaj.org/article/5b17b69d7358490680525dca5b3d78a1

Zobrazit plný text záznamu

Akademický článek

CRM1-spike-mediated nuclear export of hepatitis B virus encapsidated viral RNA

Autor: Ching-Chun Yang, Chih-Hsu Chang, Heng-Li Chen, Ming-Chieh Chou, Ching-Jen Yang, Ren-Shiang Jhou, Er-Yi Huang, Hung-Cheng Li, Ching-Shu Suen, Ming-Jing Hwang, Chiaho Shih

Publikováno v: Cell Reports, Vol 38, Iss 10, Pp 110472- (2022)

Summary: Hepatitis B virus (HBV) is a global pathogen. We report here that the cellular CRM1 machinery can mediate nuclear export of entire HBV core (HBc) particles containing encapsidated viral RNAs. Two CRM1-mediated nuclear export signals (NESCRM1

Externí odkaz: https://doaj.org/article/5a528bb9aafa41d2b5d8fc3ad3130db4

Zobrazit plný text záznamu

NLRP3 inflammasome activation, metabolic danger signals, and protein binding partners

Autor: Sy-Ying Leu, Yi-Ling Tsang, Li-Chun Ho, Ching-Chun Yang, Ai-Ning Shao, Chia-Yu Chang, Hui-Kuan Lin, Pei-Jane Tsai, Junne-Ming Sung, Yau-Sheng Tsai

Publikováno v: Journal of Endocrinology. 257

The NOD-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome is an oligomeric complex that assembles in response to exogenous signals of pathogen infection and endogenous danger signals of non-microbial origin. When NLRP3 inflammasome

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ad3413ee7eb4ccac2cdc056e94382252
https://doi.org/10.1530/joe-22-0184

Zobrazit plný text záznamu

Inhibitory effect of PPARγ on NLRP3 inflammasome activation

Autor: Yi Ning Cheng, Chih Hsing Wu, Kuo Ting Lee, Ching Chun Yang, Pei Jane Tsai, Yau Sheng Tsai, Ta Chun Lin, Chin Sung Chang

Publikováno v: Theranostics

Rationale: Stimulation of the NLRP3 inflammasome by metabolic byproducts is known to result in inflammatory responses and metabolic diseases. However, how the host controls aberrant NLRP3 inflammasome activation remains unclear. PPARγ, a known regul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a98b5a11ac219249286861e18c38eae
https://doi.org/10.7150/thno.46873

Zobrazit plný text záznamu

Loss of EGR-1 uncouples compensatory responses of pancreatic β cells

Autor: Yan Shen Shan, Yun-Wen Chen, Yau Sheng Tsai, Junne Ming Sung, Pei Jane Tsai, Ching-Chun Yang, Yi-Ning Cheng, Po-Hsiu Chien, Li-Chun Ho, Wen-Tsan Weng, Tai-Tzu Hsieh, Li-Hua Kuo, Shun Hua Chen, Sy-Ying Leu, I-Chia Lien

Publikováno v: Theranostics

Rationale: Subjects unable to sustain β-cell compensation develop type 2 diabetes. Early growth response-1 protein (EGR-1), implicated in the regulation of cell differentiation, proliferation, and apoptosis, is induced by diverse metabolic challenge

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d90363d32d0d52fb2e93e29978396d9
https://doi.org/10.7150/thno.40664

Zobrazit plný text záznamu

Akademický článek

Influenza A Virus PB1-F2 Gene in Recent Taiwanese Isolates

Autor: Guang-Wu Chen, Ching-Chun Yang, Kuo-Chien Tsao, Chung-Guei Huang, Li-Ang Lee, Wen-Zhi Yang, Ya-Ling Huang, Tzou-Yien Lin, Shin-Ru Shih

Publikováno v: Emerging Infectious Diseases, Vol 10, Iss 4, Pp 630-636 (2004)

Influenza A virus contains eight RNA segments and encodes 10 viral proteins. However, an 11th protein, called PB1-F2, was found in A/Puerto Rico/8/34 (H1N1). This novel protein is translated from an alternative open reading frame (ORF) in the PB1 gen

Externí odkaz: https://doaj.org/article/770e852193b54712a0828a2bcacaf89c

Zobrazit plný text záznamu

Akademický článek

Nuclear export of human hepatitis B virus core protein and pregenomic RNA depends on the cellular NXF1-p15 machinery.

Autor: Ching-Chun Yang, Er-Yi Huang, Hung-Cheng Li, Pei-Yi Su, Chiaho Shih

Publikováno v: PLoS ONE, Vol 9, Iss 10, p e106683 (2014)

Hepatitis B virus (HBV) core protein (HBc) can shuttle between nucleus and cytoplasm. Cytoplasm-predominant HBc is clinically associated with severe liver inflammation. Previously, we found that HBc arginine-rich domain (ARD) can associate with a hos

Externí odkaz: https://doaj.org/article/c4ba329739724631bb5ca15049c2a54d

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání