Zobrazeno 1 - 10
of 88
pro vyhledávání: '"Chincisan A"'
Autor:
Kara, Eleanna, Crimi, Alessandro, Wiedmer, Anne, Emmenegger, Marc, Manzoni, Claudia, Bandres-Ciga, Sara, D’Sa, Karishma, Reynolds, Regina H., Botía, Juan A., Losa, Marco, Lysenko, Veronika, Carta, Manfredi, Heinzer, Daniel, Avar, Merve, Chincisan, Andra, Blauwendraat, Cornelis, García-Ruiz, Sonia, Pease, Daniel, Mottier, Lorene, Carrella, Alessandra, Beck-Schneider, Dezirae, Magalhães, Andreia D., Aemisegger, Caroline, Theocharides, Alexandre P.A., Fan, Zhanyun, Marks, Jordan D., Hopp, Sarah C., Abramov, Andrey Y., Lewis, Patrick A., Ryten, Mina, Hardy, John, Hyman, Bradley T., Aguzzi, Adriano
Publikováno v:
In Cell Reports 8 June 2021 35(10)
Autor:
Assunta Senatore, Karl Frontzek, Marc Emmenegger, Andra Chincisan, Marco Losa, Regina Reimann, Geraldine Horny, Jingjing Guo, Sylvie Fels, Silvia Sorce, Caihong Zhu, Nathalie George, Stefan Ewert, Thomas Pietzonka, Simone Hornemann, Adriano Aguzzi
Publikováno v:
EMBO Molecular Medicine, Vol 12, Iss 9, Pp 1-19 (2020)
Abstract Prion immunotherapy may hold great potential, but antibodies against certain PrP epitopes can be neurotoxic. Here, we identified > 6,000 PrP‐binding antibodies in a synthetic human Fab phage display library, 49 of which we characterized in
Externí odkaz:
https://doaj.org/article/c41b503363134ee683fd9afef525f6b5
Autor:
Daniel Heinzer, Merve Avar, Daniel Patrick Pease, Ashutosh Dhingra, Jiang-An Yin, Elke Schaper, Berre Doğançay, Marc Emmenegger, Anna Spinelli, Kevin Maggi, Andra Chincisan, Simon Mead, Simone Hornemann, Peter Heutink, Adriano Aguzzi
Publikováno v:
PLoS Pathogens, Vol 17, Iss 10 (2021)
The cellular prion protein PrPC is necessary for prion replication, and its reduction greatly increases life expectancy in animal models of prion infection. Hence the factors controlling the levels of PrPC may represent therapeutic targets against hu
Externí odkaz:
https://doaj.org/article/0bb9cfda63ef41b79c0071537284dc38
Autor:
Silvia Sorce, Mario Nuvolone, Giancarlo Russo, Andra Chincisan, Daniel Heinzer, Merve Avar, Manuela Pfammatter, Petra Schwarz, Mirzet Delic, Micha Müller, Simone Hornemann, Despina Sanoudou, Claudia Scheckel, Adriano Aguzzi
Publikováno v:
PLoS Pathogens, Vol 16, Iss 6, p e1008653 (2020)
The clinical course of prion diseases is accurately predictable despite long latency periods, suggesting that prion pathogenesis is driven by precisely timed molecular events. We constructed a searchable genome-wide atlas of mRNA abundance and splici
Externí odkaz:
https://doaj.org/article/3378ce74ef8f40b7a548373f25fdab25
Autor:
Annika Keller, Mario Nuvolone, Irina Abakumova, Andra Chincisan, Regina Reimann, Merve Avar, Daniel Heinzer, Simone Hornemann, Josephin Wagner, Daniel Kirschenbaum, Fabian F Voigt, Caihong Zhu, Luca Regli, Fritjof Helmchen, Adriano Aguzzi
Publikováno v:
PLoS Pathogens, Vol 14, Iss 11, p e1007424 (2018)
Transmissible spongiform encephalopathies (TSEs) are caused by the prion, which consists essentially of PrPSc, an aggregated, conformationally modified form of the cellular prion protein (PrPC). Although TSEs can be experimentally transmitted by intr
Externí odkaz:
https://doaj.org/article/154e8661ae744cb885de7f2073c95e14
Autor:
Avar, Merve, Heinzer, Daniel, Thackray, Alana M, Liu, Yingjun, Hruska‐Plochan, Marian, Sellitto, Stefano, Schaper, Elke, Pease, Daniel P, Yin, Jiang‐An, Lakkaraju, Asvin KK, Emmenegger, Marc, Losa, Marco, Chincisan, Andra, Hornemann, Simone, Polymenidou, Magdalini, Bujdoso, Raymond, Aguzzi, Adriano
Funder: Donation from the Estate of Dr Hans Salvisberg
Funder: Nomis Foundation; Id: http://dx.doi.org/10.13039/501100008483
A defining characteristic of mammalian prions is their capacity for self-sustained propagation. Theoretical conside
Funder: Nomis Foundation; Id: http://dx.doi.org/10.13039/501100008483
A defining characteristic of mammalian prions is their capacity for self-sustained propagation. Theoretical conside
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ead20968a0f89ca07a3af670f227b543
https://www.zora.uzh.ch/id/eprint/230580/
https://www.zora.uzh.ch/id/eprint/230580/
Autor:
Marc Emmenegger, A. D. Magalhaes, Simone Hornemann, Andra Chincisan, Karl Frontzek, E. De Cecco, Adriano Aguzzi, Manfredi Carta
The microtubule-associated protein tau is involved in several neurodegenerative diseases and is currently being investigated as a plasma biomarker for the detection and monitoring of Alzheimer’s disease and as an immunotherapeutical target in clini
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b7e549f9231bab61714ea2a07748c8a1
https://doi.org/10.1101/2021.11.24.21266833
https://doi.org/10.1101/2021.11.24.21266833
Autor:
Simon Mead, Simone Hornemann, Marc Emmenegger, Elke Schaper, Kevin Maggi, Peter Heutink, Jiang-An Yin, Anna Spinelli, Ashutosh Dhingra, Daniel Heinzer, Berre Doğançay, Merve Avar, Daniel Patrick Pease, Adriano Aguzzi, Andra Chincisan
Publikováno v:
PLoS Pathogens, Vol 17, Iss 10 (2021)
PLoS pathogens 17(10), e1010013 (2021). doi:10.1371/journal.ppat.1010013
PLoS Pathogens, Vol 17, Iss 10, p e1010013 (2021)
PLoS Pathogens
PLoS pathogens 17(10), e1010013 (2021). doi:10.1371/journal.ppat.1010013
PLoS Pathogens, Vol 17, Iss 10, p e1010013 (2021)
PLoS Pathogens
The cellular prion protein PrPC is necessary for prion replication, and its reduction greatly increases life expectancy in animal models of prion infection. Hence the factors controlling the levels of PrPC may represent therapeutic targets against hu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59f070e22194fd9e3258e126ce44b9be
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8575309/?tool=EBI
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8575309/?tool=EBI
Akademický článek
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Publikováno v:
Cell Reports
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=r3c4b2081b22::b40b27e19217ec952405e268043f8c7a