Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Chinaza Egbuta"'
Autor:
Unnati M. Pandya, Chinaza Egbuta, Trefa M. Abdullah Norman, Chih-Yuan (Edward) Chiang, Valerie R. Wiersma, Rekha G. Panchal, Edwin Bremer, Paul Eggleton, Leslie I Gold
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 2, p 408 (2019)
The endoplasmic reticulum (ER) chaperone protein, calreticulin (CRT), is essential for proper glycoprotein folding and maintaining cellular calcium homeostasis. During ER stress, CRT is overexpressed as part of the unfolded protein response (UPR). In
Externí odkaz:
https://doaj.org/article/ea26aac3bf024ba5b3e4c9e177b8e6b1
Autor:
Chinaza Egbuta, Miguel A. Manzanares, Unnati M. Pandya, Fares Samra, Ana Tellechea, Leslie I. Gold, Alexa Fredston-Hermann, Khalil Saadipour, Julien Daubriac, Couger Jimenez-Jaramillo
Publikováno v:
The FASEB Journal. 34:15849-15874
Topical application of extracellular calreticulin (eCRT), an ER chaperone protein, in animal models enhances wound healing and induces tissue regeneration evidenced by epidermal appendage neogenesis and lack of scarring. In addition to chemoattractio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::478702da44563fb534d7db7ba381293b
https://doi.org/10.1096/fj.202001161r
https://doi.org/10.1096/fj.202001161r
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 181:11-19
Cytochrome P450 aromatase (AROM) catalyzes the biosynthesis of estrogen from androgen. Previously crystal structures of human AROM in complex with the substrate androstenedione, and inhibitors exemestane, as well as the newly designed steroidal compo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f3c1d723c6a35a42d93e66991ded5ad
https://doi.org/10.1016/j.jsbmb.2018.02.009
https://doi.org/10.1016/j.jsbmb.2018.02.009
Publikováno v:
Journal of Medicinal Chemistry. 59:5131-5148
Human aromatase catalyzes the synthesis of estrogen from androgen with high substrate specificity. For the past 40 years, aromatase has been a target of intense inhibitor discovery research for the prevention and treatment of estrogen-dependent breas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05ee8d7abe897a8edbb2e296ad00d07d
https://doi.org/10.1021/acs.jmedchem.5b01281
https://doi.org/10.1021/acs.jmedchem.5b01281
Autor:
Chinaza Egbuta, Paul Eggleton, Valerie R. Wiersma, Trefa M Abdullah Norman, Edwin Bremer, Chih-Yuan Edward Chiang, Rekha G. Panchal, Unnati M. Pandya, Leslie I. Gold
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 2, p 408 (2019)
International Journal of Molecular Sciences
Volume 20
Issue 2
International Journal of Molecular Sciences, 20(2):408. MDPI AG
International Journal of Molecular Sciences
Volume 20
Issue 2
International Journal of Molecular Sciences, 20(2):408. MDPI AG
The endoplasmic reticulum (ER) chaperone protein, calreticulin (CRT), is essential for proper glycoprotein folding and maintaining cellular calcium homeostasis. During ER stress, CRT is overexpressed as part of the unfolded protein response (UPR). In
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a906d03a8546c5b7aeeb37d972b6184
https://doi.org/10.3390/ijms20020408
https://doi.org/10.3390/ijms20020408
Autor:
Chinaza Egbuta, Gianfranco Gilardi, Jessica Lo, Debashis Ghosh, Giovanna Di Nardo, Wenhua Jiang, Jennifer Griswold
Publikováno v:
Biochemistry. 52:5821-5829
Cytochrome P450 aromatase (CYP19A1) is the only enzyme known to catalyze the biosynthesis of estrogens from androgens. The crystal structure of human placental aromatase (pArom) has paved the way toward understanding the structure-function relationsh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff4746d2adb6759f51509ed096be8486
https://doi.org/10.1021/bi400669h
https://doi.org/10.1021/bi400669h
Autor:
Chinaza Egbuta, Jessica Lo, Susan Hubbell, Jingle Xi, Debashis Ghosh, Daniel Morton, Damien Valette, Jennifer Griswold, Huw M. L. Davies, Jing An, Wenhua Jiang
Publikováno v:
Journal of Medicinal Chemistry. 55:8464-8476
Human cytochrome P450 aromatase catalyzes with high specificity the synthesis of estrogens from androgens. Aromatase inhibitors (AIs) such as exemestane, 6-methylideneandrosta-1,4-diene-3,17-dione, are preeminent drugs for the treatment of estrogen-d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b59ff685777f71791738c21905aa535
https://doi.org/10.1021/jm300930n
https://doi.org/10.1021/jm300930n
Autor:
Shanshan Duan, Leslie I. Gold, John K. Dickson, Nadim Shohdy, Xinyan Huang, Miguel A. Manzanares, Julien Dubrulle, Yunfeng Li, Mirco Meniconi, Bing Hao, Michael A. Mancini, Michelle Pagano, Chinaza Egbuta, Kuo-sen Huang, Ana Tellechea
Publikováno v:
Cancer Research. 78:5231-5231
We have previously shown that ubiquitin-mediated degradation of the cyclin-dependent kinase inhibitor, p27kip1 (p27), critical for G1 arrest, is involved in the pathogenesis of Type I endometrial cancer (ECA; 80% of ECAs), which is estrogen (E2) indu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::804a07906c0707e5542b22da88d73b57
https://doi.org/10.1158/1538-7445.am2018-5231
https://doi.org/10.1158/1538-7445.am2018-5231
Publikováno v:
Steroids. 76(8)
Aromatase (CYP19A1) is an integral membrane enzyme that catalyzes the removal of the 19-methyl group and aromatization of the A-ring of androgens. All human estrogens are synthesized from their androgenic precursors by this unique cytochrome P450. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58d688132ffc2a97e2eb54ad93061442
https://pubmed.ncbi.nlm.nih.gov/21392520
https://pubmed.ncbi.nlm.nih.gov/21392520