Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Chinavenmeni S. Velu"'
Autor:
Clemencia Colmenares, Amit Verma, Kith Pradhan, H. Leighton Grimes, Chinavenmeni S. Velu, David E. Muench, Nathan Salomonis, Matthew T. Weirauch, Kyle Ferchen, Kashish Chetal, Xiaoting Chen
Publikováno v:
Blood. 132:e24-e34
The transforming growth factor beta (TGF-β) signaling pathway controls hematopoietic stem cell (HSC) behavior in the marrow niche; however, TGF-β signaling becomes chronic in early-stage myelodysplastic syndrome (MDS). Although TGF-β signaling nor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1ff22ff1954b5342892d2c5084bfdb4
https://doi.org/10.1182/blood-2018-06-860890
https://doi.org/10.1182/blood-2018-06-860890
Autor:
Paritha I Arumugam, Fabrizia Urbinati, Chinavenmeni S Velu, Tomoyasu Higashimoto, H Leighton Grimes, Punam Malik
Publikováno v:
PLoS ONE, Vol 4, Iss 9, p e6995 (2009)
Chromatin insulators separate active transcriptional domains and block the spread of heterochromatin in the genome. Studies on the chicken hypersensitive site-4 (cHS4) element, a prototypic insulator, have identified CTCF and USF-1/2 motifs in the pr
Externí odkaz:
https://doaj.org/article/15b5776a3d7144058cef5583685da0d2
Autor:
Anil G. Jegga, Guido Marcucci, Craig T. Jordan, Jianjun Chen, Mark Wunderlich, Monica L. Guzman, Balkrishen Bhat, Bruce J. Aronow, H. Leighton Grimes, James C. Mulloy, James D. Phelan, Aditya Chaubey, Shane R. Horman, Chinavenmeni S. Velu, Jose A. Cancelas, Nancy J. Zeleznik-Le, Brian Gebelein
Publikováno v:
Journal of Clinical Investigation. 124:222-236
Acute myelogenous leukemia (AML) subtypes that result from oncogenic activation of homeobox (HOX) transcription factors are associated with poor prognosis. The HOXA9 transcription activator and growth factor independent 1 (GFI1) transcriptional repre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c68e2626d00fd58823055a37189de2c
https://doi.org/10.1172/jci66005
https://doi.org/10.1172/jci66005
Autor:
Shunqian Jin, Kenneth D. Patrene, H. Leighton Grimes, Benedicte Sammut, Shibing Yu, Quanhong Sun, Chang Sook Hong, Davide Del Prete, Guozhi Xiao, Sonia D'Souza, Deborah L. Galson, G. David Roodman, Judith L. Anderson, Alissa Huston, Chinavenmeni S. Velu, Flavia Esteve Kostov
Publikováno v:
Blood. 118:6871-6880
Protracted inhibition of osteoblast (OB) differentiation characterizes multiple myeloma (MM) bone disease and persists even when patients are in long-term remission. However, the underlying pathophysiology for this prolonged OB suppression is unknown
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db5e30827d53e32c7bef177b57ee9aad
https://doi.org/10.1182/blood-2011-04-346775
https://doi.org/10.1182/blood-2011-04-346775
Autor:
David Muench, Kyle Ferchen, Chinavenmeni S. Velu, Kith Pradhan, Kashish Chetal, Clemencia Colmenares, Amit Verma, Nathan Salomonis, H. Leighton Grimes
Publikováno v:
Blood. 132:4350-4350
The transforming growth factor-beta (TGFβ) signaling pathway controls hematopoietic stem cell (HSC) behavior in the marrow niche; however, TGFb signaling becomes chronic in early-stage myelodysplasia (MDS) where it may select MDS-genic HSC clones. I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::572be7406215a1b0e54fa30b984dfd43
https://doi.org/10.1182/blood-2018-99-119441
https://doi.org/10.1182/blood-2018-99-119441
Autor:
David A. Hildeman, Pulak Tripathi, Fukun Guo, H. Leighton Grimes, Chinavenmeni S. Velu, Yi Zheng
Publikováno v:
Proceedings of the National Academy of Sciences. 107:18505-18510
T-cell homeostasis is essential for normal functioning of the immune system. IL-7 receptor (IL-7R) and T-cell receptor (TCR) signaling are pivotal for T-cell homeostatic regulation. The detailed mechanisms regulating T-cell homeostasis and how IL-7R
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fdfc6b1a201f09d717d21f715306440
https://doi.org/10.1073/pnas.1010249107
https://doi.org/10.1073/pnas.1010249107
Publikováno v:
Blood. 114:2909-2916
Cdc42 is a member of the Rho GTPase family that has been implicated in several cell functions including proliferation and migration, but its physiologic role needs to be dissected in each cell type. We achieved B-cell and hematopoietic stem cell dele
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f467585a652af21ee994f9f7e156c0b
https://doi.org/10.1182/blood-2009-04-214676
https://doi.org/10.1182/blood-2009-04-214676
Autor:
William E. Paul, Chinavenmeni S. Velu, Tristan Bourdeau, Jinfang Zhu, H. Leighton Grimes, Shane R. Horman, Brian Gebelein, Aditya Chaubey
Publikováno v:
Blood. 113:5466-5475
In patients with severe congenital neutropenia (SCN) and mice with growth factor independent-1 (Gfi1) loss of function, arrested myeloid progenitors accumulate, whereas terminal granulopoiesis is blocked. One might assume that Gfi-null progenitors ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7481d2030585b8072f36b9ef5280ef55
https://doi.org/10.1182/blood-2008-09-179747
https://doi.org/10.1182/blood-2008-09-179747
Autor:
Avedis Kazanjian, Diego E. Montoya-Durango, H. Leighton Grimes, Meghan E. B. Rojas, Gregory D. Longmore, Chinavenmeni S. Velu, Chris M. Jay
Publikováno v:
Journal of Biological Chemistry. 283:32056-32065
Growth factor independent-1 (Gfi1) is a zinc finger protein with a SNAG-transcriptional repressor domain. Ajuba is a LIM domain protein that shuttles between the cytoplasm and the nucleus. Ajuba functions as a co-repressor for synthetic Gfi1 SNAG-rep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::baab02ed87ff17466876cc4ee39a4c27
https://doi.org/10.1074/jbc.m802320200
https://doi.org/10.1074/jbc.m802320200
Publikováno v:
Methods in Molecular Biology ISBN: 9781627030076
MicroRNAs (miRNAs) are highly conserved small RNAs which regulate gene expression primarily through base pairing to the 3′ untranslated region of target messenger RNA (mRNA), leading to mRNA degradation or translation inhibition depending on the co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1891f3974a18e958cad5d10b592689a7
https://doi.org/10.1007/978-1-62703-008-3_15
https://doi.org/10.1007/978-1-62703-008-3_15
