Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Chinatsu Kamikokuryo"'
Autor:
Kenshin Shimono, Takashi Ito, Chinatsu Kamikokuryo, Shuhei Niiyama, Shingo Yamada, Hirokazu Onishi, Hideaki Yoshihara, Ikuro Maruyama, Yasuyuki Kakihana
Publikováno v:
Thrombosis Journal, Vol 21, Iss 1, Pp 1-9 (2023)
Abstract Background Upon cellular injury, damage-associated molecular patterns (DAMPs) are released into the extracellular space and evoke proinflammatory and prothrombotic responses in animal models of sterile inflammation. However, in clinical sett
Externí odkaz:
https://doaj.org/article/143e0f6f3bf446d59c4cf6e14e30df40
Autor:
Yutaro Madokoro, Chinatsu Kamikokuryo, Shuhei Niiyama, Takashi Ito, Satoshi Hara, Hiroshi Ichinose, Yasuyuki Kakihana
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Oxidation of BH4, a cofactor of nitric oxide synthase (NOS), produces reactive oxygen species (ROS) through uncoupling of NOS and affects vascular endothelial dysfunction. Ascorbic acid (AsA) inhibits the oxidation of BH4 and reduces ROS. However, th
Externí odkaz:
https://doaj.org/article/a8064972502749719bba3590fe8b7a01
Autor:
Satoshi Hara, Tama Sanatani, Natsuo Tachikawa, Yukihiro Yoshimura, Nobuyuki Miyata, Hiroaki Sasaki, Risa Kuroda, Chinatsu Kamikokuryo, Tomohiro Eguchi, Shuhei Niiyama, Yasuyuki Kakihana, Hiroshi Ichinose
Publikováno v:
Heliyon, Vol 8, Iss 5, Pp e09371- (2022)
Background: Neopterin (NP) is a biomarker for activated cellular immunity and is elevated in diseases including viral and bacterial infections, autoimmune diseases, and cancer. However, the clinical assessment of neopterin has not been used for these
Externí odkaz:
https://doaj.org/article/08bdf100546844748a192ce65ec1558a
Autor:
Kosaku Hatanaka, Takashi Ito, Yutaro Madokoro, Chinatsu Kamikokuryo, Shuhei Niiyama, Shingo Yamada, Ikuro Maruyama, Yasuyuki Kakihana
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 8 (2021)
Background: Sepsis is defined as life-threatening organ dysfunction caused by dysregulated host responses to infection. Recent studies have suggested that endotheliopathy may be the common basis for multiple organ failure in sepsis. Under septic cond
Externí odkaz:
https://doaj.org/article/19e0edb065b444b4be541b99414f1dc2
Autor:
Hiroaki Furubeppu, Takashi Ito, Midori Kakuuchi, Tomotsugu Yasuda, Chinatsu Kamikokuryo, Shingo Yamada, Ikuro Maruyama, Yasuyuki Kakihana
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
BackgroundSkeletal muscle ischemia/reperfusion (I/R) injury is an important clinical issue that can cause remote organ injury. Although its pathogenesis has not been fully elucidated, recent studies have suggested that damage-associated molecular pat
Externí odkaz:
https://doaj.org/article/72fdcbaf7abe45979e42857fe914c03c
Autor:
Yayoi Yokoyama, Takashi Ito, Tomotsugu Yasuda, Hiroaki Furubeppu, Chinatsu Kamikokuryo, Shingo Yamada, Ikuro Maruyama, Yasuyuki Kakihana
Publikováno v:
Thrombosis Journal, Vol 17, Iss 1, Pp 1-7 (2019)
Abstract Background Nuclear histone proteins are released into the extracellular space, and act as major mediators of coagulopathy and remote organ failure in septic animals. However, the circulating histone levels in septic patients have not been pr
Externí odkaz:
https://doaj.org/article/9500dc76080a4fc39bcb6df2819184d8
Autor:
Koichiro Suemori, Masayuki Saijo, Atsushi Yamanaka, Daisuke Himeji, Masafumi Kawamura, Takashi Haku, Michihiro Hidaka, Chinatsu Kamikokuryo, Yasuyuki Kakihana, Taichi Azuma, Katsuto Takenaka, Toru Takahashi, Akitsugu Furumoto, Toshiyuki Ishimaru, Masayuki Ishida, Masahiko Kaneko, Norimitsu Kadowaki, Kenichi Ikeda, Shigetoshi Sakabe, Tomohiro Taniguchi, Hiroki Ohge, Takeshi Kurosu, Tomoki Yoshikawa, Masayuki Shimojima, Masaki Yasukawa
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 15, Iss 2, p e0009103 (2021)
Severe fever with thrombocytopenia syndrome (SFTS) is a bunyavirus infection with high mortality. Favipiravir has shown effectiveness in preventing and treating SFTS virus (SFTSV) infection in animal models. A multicenter non-randomized, uncontrolled
Externí odkaz:
https://doaj.org/article/920dd2f0bda94c97829881ddaf926a42
Autor:
Takashi Ito, Mayumi Nakahara, Yoshiki Masuda, Sachie Ono, Shingo Yamada, Hiroyasu Ishikura, Hitoshi Imaizumi, Chinatsu Kamikokuryo, Yasuyuki Kakihana, Ikuro Maruyama
Publikováno v:
Journal of Intensive Care, Vol 6, Iss 1, Pp 1-6 (2018)
Abstract Background Nuclear histone proteins are released into the extracellular space during sepsis and act as major mediators of death. However, circulating histone levels have not been precisely quantified. Methods We developed a novel enzyme-link
Externí odkaz:
https://doaj.org/article/cac994eecd734d4cafc7ac2abd62f3b4
Autor:
Takuro Arishima, Takashi Ito, Tomotsugu Yasuda, Nozomi Yashima, Hiroaki Furubeppu, Chinatsu Kamikokuryo, Takahiro Futatsuki, Yutaro Madokoro, Shotaro Miyamoto, Tomohiro Eguchi, Hiroyuki Haraura, Ikuro Maruyama, Yasuyuki Kakihana
Publikováno v:
Thrombosis Journal, Vol 16, Iss 1, Pp 1-7 (2018)
Abstract Background Recombinant human soluble thrombomodulin (rTM) has been used for the treatment of disseminated intravascular coagulation in Japan, and an international phase III clinical trial for rTM is currently in progress. rTM mainly exerts i
Externí odkaz:
https://doaj.org/article/da843b2c0fd24c6f91b2e21f13318f91
Autor:
Chinatsu Kamikokuryo, Satoshi Hara, Yasuyuki Kakihana, Hiroshi Ichinose, Yutaro Madokoro, Takashi Ito, Shuhei Niiyama
Publikováno v:
Frontiers in Pharmacology. 13
Background: Ascorbic acid (AsA) therapy for sepsis is thought to have a protective effect on vascular endothelial cells. However, the effect of AsA therapy on endothelial cell dysfunction over time and the appropriate timing for AsA administration to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32a63c0ad43bb26fedcbe24d4ead9673
https://doi.org/10.3389/fphar.2022.929448
https://doi.org/10.3389/fphar.2022.929448