Zobrazeno 1 - 10
of 21
pro vyhledávání: '"China N. Byrns"'
Autor:
Lihong Sheng, Emily J. Shields, Janko Gospocic, Masato Sorida, Linyang Ju, China N. Byrns, Faith Carranza, Shelley L. Berger, Nancy Bonini, Roberto Bonasio
Publikováno v:
Aging Cell. 22
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0cb88c521f414a0afd3abb30895be62d
https://doi.org/10.1111/acel.13803
https://doi.org/10.1111/acel.13803
Publikováno v:
Nat Aging
The emergence of degenerative disease after traumatic brain injury is often described as an acceleration of normal age-related processes. Whether similar molecular processes occur after injury and in age is unclear. Here we identify a functionally dy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c7259f78d2db60562db46d95c5a2c44
https://doi.org/10.1038/s43587-021-00072-0
https://doi.org/10.1038/s43587-021-00072-0
The emergence of degenerative disease after traumatic brain injury is often described as an acceleration of normal age-related processes. Whether similar molecular processes occur in injury and in age is unclear. Here we identify a functionally dynam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::27e2ae46d217d4de5f443ecfd6be9046
https://doi.org/10.1101/2021.06.17.448817
https://doi.org/10.1101/2021.06.17.448817
Autor:
Nancy M. Bonini, Oksana Shcherbakova, Alexandra E Perlegos, China N. Byrns, Olivia M. Rifai, Faith R Carranza, Hyung-Jun Kim, Henry W Zhou, Leeanne McGurk, Yongqing Zhu
Publikováno v:
Human Molecular Genetics
Spinocerebellar ataxia type 2 is a polyglutamine (polyQ) disease associated with an expanded polyQ domain within the protein product of the ATXN2 gene. Interestingly, polyQ repeat expansions in ATXN2 are also associated with amyotrophic lateral scler
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b94082898927c78b8a9c537fb47d87d
https://pubmed.ncbi.nlm.nih.gov/34077532
https://pubmed.ncbi.nlm.nih.gov/34077532
Autor:
Jay Shendure, Megan L. Clark, Robert J. Norgard, Kamen P. Simeonov, China N. Byrns, Aaron McKenna, Ben Z. Stanger, Christopher J. Lengner, Beth Martin
Metastatic cancer remains largely incurable due to an incomplete understanding of how cancer cells disseminate throughout the body. However, tools for probing metastatic dissemination and associated molecular changes at high resolution are lacking. H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f1734ed19ab3b6f4cdd923b63a3c8346
https://doi.org/10.1101/2020.08.11.245787
https://doi.org/10.1101/2020.08.11.245787
Dynamic neural and glial responses of a head-specific model for traumatic brain injury in Drosophila
Publikováno v:
Proc Natl Acad Sci U S A
Traumatic brain injury (TBI) is the strongest environmental risk factor for the accelerated development of neurodegenerative diseases. There are currently no therapeutics to address this due to lack of insight into mechanisms of injury progression, w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17b140066698a0fac852a45b2ee1ace5
https://europepmc.org/articles/PMC7382229/
https://europepmc.org/articles/PMC7382229/
Autor:
Janani Saikumar, Joshua Kim, Nancy M. Bonini, Matthew A. Hemphill, China N. Byrns, David F. Meaney
Drosophila models have been instrumental in providing insights into molecular mechanisms of neurodegeneration, that are applicable to human disease. We have recently described a model of controlled head injury to flies, which remarkably parallels man
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9a71eabce83b11225de6e617a6d90186
https://doi.org/10.21203/rs.3.pex-949/v1
https://doi.org/10.21203/rs.3.pex-949/v1
Inducing different severities of traumatic brain injury in Drosophila using a piezoelectric actuator
Autor:
Joshua Kim, Nancy M. Bonini, David F. Meaney, Matthew A. Hemphill, Janani Saikumar, China N. Byrns
Publikováno v:
Nat Protoc
Drosophila models have been instrumental in providing insights into molecular mechanisms of neurodegeneration, with wide applications to human disease. The brain degeneration associated with traumatic brain injury (TBI) has been modeled in Drosophila
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2684f0e145d4f9a30d5f84a8e371f7dd
https://pubmed.ncbi.nlm.nih.gov/33277631
https://pubmed.ncbi.nlm.nih.gov/33277631
Autor:
China N. Byrns, Nancy M. Bonini
Publikováno v:
Neuron
To identify the molecular mechanisms and novel therapeutic targets of late-onset Alzheimer’s Disease (LOAD), we performed an integrative network analysis of multi-Omic profiling of four cortical areas across 364 donors with varying cognitive and ne
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::525306dc558a6030aada9351dc01db94
https://doi.org/10.1016/j.neuron.2020.12.015
https://doi.org/10.1016/j.neuron.2020.12.015
Autor:
Jay Shendure, Beth Martin, Megan L. Clark, Kamen P. Simeonov, Christopher J. Lengner, Ben Z. Stanger, Aaron McKenna, Robert J. Norgard, China N. Byrns
Publikováno v:
Cancer Cell. 39:1150-1162.e9
Summary The underpinnings of cancer metastasis remain poorly understood, in part due to a lack of tools for probing their emergence at high resolution. Here we present macsGESTALT, an inducible CRISPR-Cas9-based lineage recorder with highly efficient
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ca53a7343c5d0cb89c58aa09b7d62fb
https://doi.org/10.1016/j.ccell.2021.05.005
https://doi.org/10.1016/j.ccell.2021.05.005