A resource database for protein kinase substrate sequence-preference motifs based on large-scale mass spectrometry data

Autor: Brian G. Poll, Kirby T. Leo, Venky Deshpande, Nipun Jayatissa, Trairak Pisitkun, Euijung Park, Chin-Rang Yang, Viswanathan Raghuram, Mark A. Knepper

Publikováno v: Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-12 (2024)

Abstract Background Protein phosphorylation is one of the most prevalent posttranslational modifications involved in molecular control of cellular processes, and is mediated by over 520 protein kinases in humans and other mammals. Identification of t

Externí odkaz: https://doaj.org/article/58a7eaa096d5461f9c37d64fd8eca33d

Bayesian analysis of dynamic phosphoproteomic data identifies protein kinases mediating GPCR responses

Autor: Kirby T. Leo, Chung-Lin Chou, Chin-Rang Yang, Euijung Park, Viswanathan Raghuram, Mark A. Knepper

Publikováno v: Cell Communication and Signaling, Vol 20, Iss 1, Pp 1-17 (2022)

Abstract Background A major goal in the discovery of cellular signaling networks is to identify regulated phosphorylation sites (“phosphosites”) and map them to the responsible protein kinases. The V2 vasopressin receptor is a G-protein coupled r

Externí odkaz: https://doaj.org/article/316a33efa3484183bbb261c726bde790

Linking splicing to Pol II transcription stabilizes pre-mRNAs and influences splicing patterns.

Autor: Martin J Hicks, Chin-Rang Yang, Matthew V Kotlajich, Klemens J Hertel

Publikováno v: PLoS Biology, Vol 4, Iss 6, p e147 (2006)

RNA processing is carried out in close proximity to the site of transcription, suggesting a regulatory link between transcription and pre-mRNA splicing. Using an in vitro transcription/splicing assay, we demonstrate that an association of RNA polymer

Externí odkaz: https://doaj.org/article/cf3042a3e34a4732ba67adaac8d51c96

Circadian gene expression in mouse renal proximal tubule

Autor: Molly A. Bingham, Kim Neijman, Chin-Rang Yang, Angel Aponte, Angela Mak, Hiroaki Kikuchi, Hyun Jun Jung, Brian G. Poll, Viswanathan Raghuram, Euijung Park, Chung-Lin Chou, Lihe Chen, Jens Leipziger, Mark A. Knepper, Margo Dona

Publikováno v: Bingham, M A, Neijman, K, Yang, C R, Aponte, A, Mak, A, Kikuchi, H, Jung, H J, Poll, B G, Raghuram, V, Park, E, Chou, C L, Chen, L, Leipziger, J, Knepper, M A & Dona, M 2023, ' Circadian gene expression in mouse renal proximal tubule ', American Journal of Physiology: Renal Physiology, vol. 324, no. 3, pp. F301-F314 . https://doi.org/10.1152/ajprenal.00231.2022
American Journal of Physiology : Renal Physiology, 324, F301-F314
American Journal of Physiology : Renal Physiology, 324, 3, pp. F301-F314

Item does not contain fulltext Circadian variability in kidney function is well recognized but is often ignored as a potential confounding variable in physiological experiments. Here, we have created a data resource consisting of expression levels fo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c037b3699b9ffbec9a72178fa392149c
https://hdl.handle.net/2066/290755

Vasopressin V2 receptor, tolvaptan, and ERK1/2 phosphorylation in the renal collecting duct.

Autor: Khan, Shaza, Raghuram, Viswanathan, Lihe Chen, Chung-Lin Chou, Chin-Rang Yang, Khundmiri, Syed J., Knepper, Mark A.

Publikováno v: American Journal of Physiology: Renal Physiology; Jan2024, Vol. 326 Issue 1, pF57-F68, 12p