Výsledky vyhledávání - "Chin-Pu Jason Chen"

Supplementary Figures 1-9, Supplementary Table 1 from Targeting Mutant PPM1D Sensitizes Diffuse Intrinsic Pontine Glioma Cells to the PARP Inhibitor Olaparib

Autor: Hai Yan, Matthew S. Waitkus, Yiping He, Liwei Zhang, Paula K. Greer, Huishan Zhu, Changzheng Du, Lee H. Chen, Chin-Pu Jason Chen, Casey J. Moure, Bill H. Diplas, Cheng Xu, Zhaohui Wang

Supplementary Fig. 1. Confirmation of SF7761 derived PPM1D-/- clones by Sanger sequencing. Supplementary Fig. 2. Effect of DNA repair inhibitors on cell viability in SF7761 parental and PPM1D-/- clones. Supplementary Fig. 3. GSK2830371 treatment syne

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09eac298f5735baf414fca4eed2478b6
https://doi.org/10.1158/1541-7786.22513743

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Targeting Mutant PPM1D Sensitizes Diffuse Intrinsic Pontine Glioma Cells to the PARP Inhibitor Olaparib

Autor: Paula K. Greer, Zhaohui Wang, Cheng Xu, Changzheng Du, Matthew S. Waitkus, Huishan Zhu, Casey J. Moure, Lee H. Chen, Yiping He, Chin-Pu Jason Chen, Bill H. Diplas, Hai Yan, Liwei Zhang

Publikováno v: Molecular cancer research : MCR. 18(7)

Diffuse intrinsic pontine glioma (DIPG) is an invariably fatal brain tumor occurring predominantly in children. Up to 90% of pediatric DIPGs harbor a somatic heterozygous mutation resulting in the replacement of lysine 27 with methionine (K27M) in ge

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ec496e438dd0b33b19e20a3fe5e7401
https://pubmed.ncbi.nlm.nih.gov/32229503

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Mutant allele quantification reveals a genetic basis for TP53 mutation-driven castration resistance in prostate cancer cells

Autor: Yiping He, Lee H. Chen, Paula K. Greer, Wenzhe Wang, Kefeng Lei, Bill H. Diplas, Yulei Tao, Casey J. Moure, Xufeng Chen, Ran Sun, Hai Yan, Jiaoti Huang, Landon J. Hansen, Darell D. Bigner, Chin-Pu Jason Chen, Fangping Zhao

Publikováno v: Scientific Reports
Scientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)

The concept that human cancer is in essence a genetic disease driven by gene mutations has been well established, yet its utilization in functional studies of cancer genes has not been fully explored. Here, we describe a simple genetics-based approac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae74b421ea6b4dd2270e47a504463670
https://pubmed.ncbi.nlm.nih.gov/30131529

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