Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Chin-Ju Park"'
Publikováno v:
ACS Omega, Vol 5, Iss 24, Pp 14513-14522 (2020)
Externí odkaz:
https://doaj.org/article/39e8cfdece4940fdba5eb42b71db710d
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 6, p 3099 (2022)
Proteins from Sulfolobus solfataricus (S. solfataricus), an extremophile, are active even at high temperatures. The single-stranded DNA (ssDNA) binding protein of S. solfataricus (SsoSSB) is overexpressed to protect ssDNA during DNA metabolism. Altho
Externí odkaz:
https://doaj.org/article/2edd143e51ad40fd901d3be3f2138c0a
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 8, p 2673 (2020)
The non-canonical structures of nucleic acids are essential for their diverse functions during various biological processes. These non-canonical structures can undergo conformational exchange among multiple structural states. Data on their dynamics c
Externí odkaz:
https://doaj.org/article/85b6e7d638d44a8db36b541e7b4f0304
Publikováno v:
Sensors, Vol 19, Iss 13, p 2857 (2019)
A simple and rapid As3+ detection method using 3-nitro-L-tyrosine (N-Tyr) is reported. We discovered the specific property of N-Tyr, which specifically chelates As3+. The reaction between As3+ and N-Tyr induces a prompt color change to vivid yellow,
Externí odkaz:
https://doaj.org/article/a2cd93ab4f4f44c4be8fd3bd42efc32f
Publikováno v:
The FEBS Journal. 289:3163-3182
Cellular senescence is protective against external oncogenic stress, but its accumulation causes aging-related diseases. Forkhead box O4 (FOXO4) and p53 are human transcription factors known to promote senescence by interacting each other and activat
Autor:
Sungjin Lee, Jihyeon Yu, Wanki Yoo, Sangsu Bae, Chan Young Kang, Kyeong Kyu Kim, Amen Shamim, Ambarnil Ghosh, Jeong Hwan Hur, Nazia Parveen, Chin-Ju Park
Publikováno v:
Nucleic Acids Research
I-motif or C4 is a four-stranded DNA structure with a protonated cytosine:cytosine base pair (C+:C) found in cytosine-rich sequences. We have found that oligodeoxynucleotides containing adenine and cytosine repeats form a stable secondary structure a
Autor:
Min Ju Kim, Jieun Choi, Chin-Ju Park, Jiwon Seo, Yong-Chul Kim, Dongjae Lee, Kyeong-Ryoon Lee, Yoo-Kyung Song, Myung Ae Bae, Jun-Ho Choi, Sungjin Lee, Dae-Seop Shin
Publikováno v:
Journal of Medicinal Chemistry. 64:8272-8286
A macrocyclic peptide scaffold with well-established structure-property relationship is desirable for tackling undruggable targets. Here, we adopted a natural macrocycle, cyclosporin O (CsO) and its derivatives (CP1-3), and evaluated the impact of co
Publikováno v:
ACS Omega, Vol 5, Iss 24, Pp 14513-14522 (2020)
ACS Omega
ACS Omega
G-quadruplex (G4) is a noncanonical DNA secondary structure formed by Hoogsteen base pairing. It is recognized by various DNA helicases involved in DNA metabolism processes such as replication and transcription. Human Bloom syndrome protein (BLM), on
Autor:
Yo-Han Song, Jungwook Kim, Donguk Kang, Chin-Ju Park, Inkyu Lee, Haushabhau S. Pagire, Kang Taek Lee, Jihoon Kang, Jin Hee Ahn
Publikováno v:
Biochemical and Biophysical Research Communications. 527:778-784
Pyruvate dehydrogenase kinase (PDK) controls the activity of pyruvate decarboxylase complex (PDC) by phosphorylating key serine residues on the E1 subunit, which leads to a decreased oxidative phosphorylation in mitochondria. Inhibition of PDK activi
Publikováno v:
Analytical chemistry. 93(50)
To effectively control the spread of new infectious diseases, there is a need for highly sensitive diagnostic methods to detect viral nucleic acids rapidly. This study outlines a universal and simple detection strategy that uses magnetic nanoparticle