Zobrazeno 1 - 10
of 71
pro vyhledávání: '"Chin-Chuan Hung"'
Autor:
Meng-Hsuan Lin, Yi-Cheng Shen, Han-Yun Cheng, Chi-Kang Teng, Wei-Cheng Chen, Yu-Chao Lin, Chin-Chuan Hung
Publikováno v:
Journal of Global Antimicrobial Resistance, Vol 34, Iss , Pp 46-58 (2023)
ABSTRACT: Objectives: The increasing epidemic of infections caused by drug-resistant Gram-negative bacteria has led to the development of several antibiotic therapies. Owing to the scarcity of head-to-head comparisons of current and emerging antibiot
Externí odkaz:
https://doaj.org/article/93be93abb57047bb9b48a0a1a1488c5f
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 156, Iss , Pp 113832- (2022)
Cancer treatment is an evolving field with various challenges to clinical practice. One unresolved problem in this field is multidrug resistance (MDR) mediated by ABC efflux transporters, particularly P-glycoprotein (P-gp). In this study, by prescree
Externí odkaz:
https://doaj.org/article/fa61006aa5084e1c987930f24ede8524
Autor:
Yu-Ning Teng, Ming-Chang Kao, Shih-Ya Huang, Tian-Shung Wu, Tsui-Er Lee, Chan-Yen Kuo, Chin-Chuan Hung
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 150, Iss , Pp 112995- (2022)
Multidrug resistance (MDR) is a multifactorial issue in cancer treatment. Drug efflux transporters, particularly P-glycoprotein (P-gp), are major contributors to such resistance. In the present study, we evaluated the P-gp-inhibiting and MDR-reversin
Externí odkaz:
https://doaj.org/article/0823098d0d5d4cdcbf69b2bf53844fa8
Publikováno v:
Pharmaceuticals, Vol 16, Iss 2, p 205 (2023)
Enhanced drug efflux through ATP-binding cassette transporters, particularly P-glycoprotein (P-gp), is a key mechanism underlying multidrug resistance (MDR). In the present study, we investigated the inhibitory effects of pinostrobin and tectochrysin
Externí odkaz:
https://doaj.org/article/60aa15db0eb64702b125cd55c4a36d97
Autor:
Yu-Ning Teng, Bo-Hau Huang, Shih-Ya Huang, I-Ting Wu, Tian-Shung Wu, Tsui-Er Lee, Chin-Chuan Hung
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 144, Iss , Pp 112379- (2021)
Cancer multi-drug resistance (MDR) caused by P-glycoprotein (P-gp) efflux is a critical unresolved clinical concern. The present study analyzed the effect of cinnamophilin on P-gp inhibition and MDR reversion. The effect of cinnamophilin on P-gp was
Externí odkaz:
https://doaj.org/article/8de39f178a3c42a8ad05755b13c86a09
Autor:
Ying-Tzu Chang, Yu-Ning Teng, Kun-I Lin, Charles C. N. Wang, Susan L. Morris-Natschke, Kuo-Hsiung Lee, Chin-Chuan Hung
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-11 (2019)
Abstract Multidrug resistance presents an obstacle in cancer treatment. Among numerous combative strategies, collateral sensitivity (CS) drugs have opened a new avenue to defeat cancer by exploiting selective toxicity against multidrug-resistant (MDR
Externí odkaz:
https://doaj.org/article/aadb4fb6502e4754853b555fcbdbf894
Autor:
Ko-Hua Yu, Chin-Chuan Hung, Tian-Shung Wu, Chin-Fu Chen, I-Ting Wu, Ping-Chung Kuo, Sio-Hong Lam, Hsin-Yi Hung
Publikováno v:
Pharmaceuticals, Vol 14, Iss 9, p 916 (2021)
Multidrug resistance (MDR), for which the mechanisms are not yet fully clear, is one of the major obstacles to cancer treatment. In recent years, signal transducer and activator of transcription 3 (STAT3) were found to be one of the important MDR mec
Externí odkaz:
https://doaj.org/article/f2f5b048a2db4d5c9c90095ab05a00ea
Publikováno v:
Journal of Functional Foods, Vol 26, Iss , Pp 681-690 (2016)
Multidrug resistance (MDR) cancer is one of the major issues in systemic chemotherapy. Development of MDR reversal agents from natural products has been considered as a potential and safe solution. The present study aimed at investigating whether cor
Externí odkaz:
https://doaj.org/article/0f337ac2788d4e21866ff6258036c363
Publikováno v:
Molecules, Vol 25, Iss 2, p 247 (2020)
Multidrug resistance (MDR) is a complicated ever-changing problem in cancer treatment, and P-glycoprotein (P-gp), a drug efflux pump, is regarded as the major cause. In the way of developing P-gp inhibitors, natural products such as phenolic acids ha
Externí odkaz:
https://doaj.org/article/3d5b0fa81d194190a774b7527e865d48
Autor:
Ruey-Yun Wang, Hsiu-Ju Chen, Chieh-Liang Huang, Jiun-Yi Wang, Tsui-Er Lee, Hsiang-Yen Lee, Chin-Chuan Hung
Publikováno v:
PLoS ONE, Vol 13, Iss 7, p e0201408 (2018)
Opioid addiction is a major public health issue worldwide. Methadone maintenance treatment (MMT) is used to detoxify users of illicit opiates, but drug relapse is common and associated with poor quality of life (QoL). This study investigated the asso
Externí odkaz:
https://doaj.org/article/13a82e06d29543e893e9df3f568f6ab3