Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Chin-Chin Lim"'
Autor:
Xixian Chen, Rehka T, Jérémy Esque, Congqiang Zhang, Sudha Shukal, Chin Chin Lim, Leonard Ong, Derek Smith, Isabelle André
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-10 (2022)
Retrosynthetic pathway design using promiscuous enzymes can provide a solution to the biosynthetic production of natural products. Here, the authors design a pathway for the production of cis-α-irone with a promiscuous methyltransferase using struct
Externí odkaz:
https://doaj.org/article/913a9e6923b0454cb3e5d54b2cd70510
Autor:
Chin Chin Lim, Yin Hoe Yau, Gang Zou, Pei Yong Shi, Yen Liang Chen, Hongping Dong, Susana Geifman Shochat, Julien Lescar, Li Jian Yap
Publikováno v:
Journal of Biological Chemistry
Flavivirus NS5 protein encodes methyltransferase and RNA-dependent RNA polymerase (RdRp) activities. Structural analysis of flavivirus RdRp domains uncovered two conserved cavities (A and B). Both cavities are located in the thumb subdomains and repr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf56704f07bc28aba586c03f225953e0
Autor:
Wai Ling Chan, Bo Zhang, Thomas H. Keller, Wouter Schul, Min Qing, Pei Yong Shi, Andy Yip, Kristen A. Bernard, Gang Zou, Hao Ying Xu, Suresh B. Lakshminarayana, Gang Wang, Anne Goh, Wei Liu, Min Dong, Boping Liu, Hui Pen Tan, Handan He, Qing Yin Wang, Margaret Weaver, Feng Gu, Yen Liang Chen, Zheng Yin, Pornwaratt Niyomrattanakit, Chuan Young Ng, Arkadius Pichota, Christine E. Garrett, Véronique Dartois, Joanne Y.H. Lim, Ravinder Reddy Kondreddi, Jeyaraj Duraiswamy, Kai Lin, Chin Chin Lim, Karen Beltz
Publikováno v:
Proceedings of the National Academy of Sciences. 106:20435-20439
Dengue virus (DENV), a mosquito-borne flavivirus, is a major public health threat. The virus poses risk to 2.5 billion people worldwide and causes 50 to 100 million human infections each year. Neither a vaccine nor an antiviral therapy is currently a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a316c5d40ed9639ddcd32990e5f5a43e
https://doi.org/10.1073/pnas.0907010106
https://doi.org/10.1073/pnas.0907010106
Autor:
Ka Yan Chung, Pei Yong Shi, Hongping Dong, Pornwaratt Niyomrattanakit, David Beer, Siti Nurdiana Abas, Cheah Chen Seh, Kah Fei Wan, Chang Bok Lee, Siew Pheng Lim, Julien Lescar, Shahul Nilar, Chin Chin Lim, Alex Chao
Publikováno v:
Antiviral research. 119
Dengue virus (DENV) NS5 protein comprises an N-terminal methyltransferase domain and a C-terminal RNA-dependent RNA polymerase domain (RdRp). DENV RdRp is responsible for viral RNA synthesis via a de novo initiation mechanism and represents an attrac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9209cdfa37cfd4c2099dcc30ed003190
https://pubmed.ncbi.nlm.nih.gov/25896272
https://pubmed.ncbi.nlm.nih.gov/25896272
Publikováno v:
Physiologia Plantarum. 116:522-530
S-Adenosylmethionine synthetase (SAMS, EC 2.5.1.6) catalyses the conversion of methionine to S-adenosylmethionine, which is a precursor of ethylene biosynthesis. To investigate whether regulation of ethylene synthesis is associated with transcript ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5cf0646c6ca5f28d3fe2beb17efed922
https://doi.org/10.1034/j.1399-3054.2002.1160411.x
https://doi.org/10.1034/j.1399-3054.2002.1160411.x
Autor:
Michael D. Green, Thitikornkovit Dumrong, Aline Plançon, Yen Hui Lau, Dana M. Hostetler, Suon Nara, Paul N. Newton, Ruth Lee Choo Ai, Mam Boravann, Sourisak Sounvoravong, Chin-Chin Lim, Nurjaya Bangsawan, Facundo M. Fernández, Min Yong Low, Yuk-Lin Yong
Publikováno v:
The American Journal of Tropical Medicine and Hygiene
Counterfeit (or falsified) and substandard medicines pose a major public health risk. We describe the findings of Operation Storm I and II conducted in 2008–2009 to combat counterfeit medicines through partnership between national customs, Drug Reg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37df9eba9a3f82334a39f4fedaf31ee6
https://pubmed.ncbi.nlm.nih.gov/26446619
https://pubmed.ncbi.nlm.nih.gov/26446619
Publikováno v:
Tetrahedron: Asymmetry. 8:2045-2050
The physically stable but chemically reactive square-planar complex (+)-[(dichloro){(S,S)-1,4-dimesyloxy-2,3-butanediamine} palladium(II)] and its platinum(II) analogue have been prepared from the reactions between the dihydrochloride salt of the dia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::87e0fce0d51423719b897b6246a29c5d
https://doi.org/10.1016/s0957-4166(97)00179-1
https://doi.org/10.1016/s0957-4166(97)00179-1
Publikováno v:
Tetrahedron: Asymmetry. 5:1883-1886
A resolution of the asymmetric ligand H 2 NCH 2 CH 2 S(O)Me, (±)- 1 , has been achieved by using ( R )-[(acetonitrile)[1-[1-(dimethylamino)ethyl]-2-naphthalenyl](triphenyl-phosphine)]palladium(II) perchlorate as the resolving agent. The ( S )- enant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8819e8ce35c307609230098e380ff542
https://doi.org/10.1016/s0957-4166(00)86257-6
https://doi.org/10.1016/s0957-4166(00)86257-6
Publikováno v:
ChemInform. 23
An efficient NMR determination of the enantiomeric excess of C 2 -symmetric 1,2-diamines can be achieved by coordination of the bidentates to the optically active forms of the diamagnetic [dimethyl(1-(2-naphthyl)ethyl)aminato- C 2 , N ]palladium(II)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::50e0502e92775bd267f5b69b4e2ef814
https://doi.org/10.1002/chin.199233066
https://doi.org/10.1002/chin.199233066
Autor:
Min Qing, Wai Ling Chan, Boping Liu, Melissa Lo, Helen Gu, Hui Pen Tan, Wouter Schul, Handan He, Ranga Rao, Hao Ying Xu, Gang Wang, Jeyaraj Duraiswamy, Thomas H. Keller, Sarah Liung, Pei Yong Shi, Yen Liang Chen, Chin Chin Lim, Ravinder Reddy Kondreddi, Andy Yip, Zheng Yin
Publikováno v:
Antimicrobial agents and chemotherapy. 54(7)
We recently reported that (2 R ,3 R ,4 R ,5 R )-2-(4-amino-pyrrolo[2,3- d ]pyrimidin-7-yl)-3-ethynyl-5-hydroxy-methyl-tetrahydro-furan-3,4-diol is a potent inhibitor of dengue virus (DENV), with 50% effective concentration (EC 50 ) and cytotoxic conc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91beaee7c743c979448a64d12f871a38
https://pubmed.ncbi.nlm.nih.gov/20457821
https://pubmed.ncbi.nlm.nih.gov/20457821