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Autor:
Luca Santarelli, Eriene A. Youssef, Jorge A. Quiroz, Christian Czech, Paulo Fontoura, Randi J Hagerman, Elizabeth Berry-Kravis, Russell Kinch, Lothar Lindemann, Michael Rabbia, Dennis Deptula, Rachel Langland, Chin Y Wong, Moritz Marcinowski, David R Hessl, Philip Drewitt, Carsten Horn, Amy John
Publikováno v:
Neuropsychopharmacology
Preclinical data suggest that inhibition of the metabotropic glutamate receptor 5 (mGluR5) receptor might hold therapeutic benefits in Fragile X syndrome (FXS). Treatment of Fmr1 knockout mice with mGluR5-negative allosteric modulators (NAMs) has bee