Virotherapy combined with anti-PD-1 transiently reshapes the tumor immune environment and induces anti-tumor immunity in a preclinical PDAC model

Autor: Rūta Veinalde, Gemma Pidelaserra-Martí, Coline Moulin, Chin Leng Tan, Theresa E. Schäfer, Na Kang, Claudia R. Ball, Jonas Leichsenring, Albrecht Stenzinger, Lars Kaderali, Dirk Jäger, Guy Ungerechts, Christine E. Engeland

Publikováno v: Frontiers in Immunology, Vol 13 (2023)

IntroductionPancreatic ductal adenocarcinoma (PDAC) is largely refractory to cancer immunotherapy with PD-1 immune checkpoint blockade (ICB). Oncolytic virotherapy has been shown to synergize with ICB. In this work, we investigated the combination of

Externí odkaz: https://doaj.org/article/ba74acb47dae49da8309a7f9f1784388

MHC class II-restricted antigen presentation is required to prevent dysfunction of cytotoxic T cells by blood-borne myeloids in brain tumors

Autor: Michael Kilian, Ron Sheinin, Chin Leng Tan, Christopher Kraemer, Mirco Friedrich, Ayelet Kaminitz, Khwab Sanghvi, Katharina Lindner, Frederik Cichon, Stafanie Jung, Kristine Jaehne, Miriam Ratliff, Robert Prins, Andreas von Deimling, Wolfgang Wick, Asaf Madi, Lukas Bunse, Michael Platten

Cancer immunotherapy critically depends on fitness of cytotoxic and helper T cell responses. Dysfunctional cytotoxic T cell states in the tumor microenvironment (TME) are a major cause of resistance to immunotherapy. Intratumoral myeloid cells, parti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b796ec78e4bab995e33c51fc64a30523
https://doi.org/10.1101/2022.06.10.495502

Common T-Cell-Receptor Motifs and Features in Patients with Cytomegalovirus (CMV)-Seronegative End-Stage Renal Disease Receiving a Peptide Vaccination against CMV

Autor: Lukas Bunse, Claudia Sommerer, Chin Leng Tan, Felix Korell, Anita Schmitt, Angela Hückelhoven-Krauss, Brigitte Neuber, Thomas Mertens, Michael Platten, Edward W. Green, Martin Zeier, Michael Schmitt

Publikováno v: International Journal of Molecular Sciences, Vol 23, Iss 1029, p 1029 (2022)
International Journal of Molecular Sciences; Volume 23; Issue 3; Pages: 1029

After solid-organ transplantation, reactivation of the cytomegalovirus (CMV) is often observed in seronegative patients and associated with a high risk of disease and mortality. CMV-specific T cells can prevent CMV reactivation. In a phase 1 trial, C

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8814d2a289436d017337bb438847984
https://www.mdpi.com/1422-0067/23/3/1029

Dichotomous response to immune checkpoint blockade in syngeneic experimental glioma allows for identification and characterization of intratumoral tumor-reactive T cells

Autor: Verena Turco, Chin Leng Tan, Dennis Alexander Agardy, Katrin Aslan, Katharina Lindner, Edward W. Green, Michael Platten, Theresa Bunse

Publikováno v: WFNOS 2022 Abstract Book.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7babead6710f6fb050f9d156929ae7dc
https://doi.org/10.14791/btrt.2022.10.f-1294

IMMU-41. HIGH-THROUGHPUT RETRIEVAL OF THERAPEUTIC T CELL RECEPTORS FROM GLIOMA

Autor: Richard Harbottle, Andreas von Deimling, Katharina A.M. Lindner, Matthias Bozza, Felix Sahm, Lukas Bunse, Khwab Sanghvi, Edward W. Green, Chin Leng Tan, Isabel Poschke, Wolfgang Wick, Michael Platten

Publikováno v: Neuro Oncol

Gliomas are tumors with low mutational burden with the majority of them being resistant to checkpoint inhibition due to few immunogenic antigens. Multicenter vaccine trials targeting personalized neoantigens in gliomas demonstrated feasibility and il

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2457548ef4fe38752e6651bb0149659f
https://doi.org/10.1093/neuonc/noaa215.471