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The effect of cotinine or cigarette smoke co-administration on the formation of O6-methylguanine adducts in the lung and liver of A/J mice treated with 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) [published erratum appears in Toxicol Sci 1999 Jul;50(1):153]

Autor: Paul H. Ayres, C.-J. G. Chang, Chin K. Lee, David J. Doolittle, Buddy G. Brown

Publikováno v: Toxicological Sciences. 47:33-39

4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), a tobacco-specific nitrosamine, induces lung adenomas in A/J mice, following a single intraperitoneal (ip) injection. However, inhalation of tobacco smoke has not induced or promoted tumors in the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::86d24dad254757f94be8af692b352a64
https://doi.org/10.1093/toxsci/47.1.33

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Comparative study of DNA adduct formation in mice following inhalation of smoke from cigarettes that burn or primarily heat tobacco

Autor: Paul H. Ayres, Betsy Bombick, Arnold T. Mosberg, Chin K. Lee, David J. Doolittle, Buddy G. Brown

Publikováno v: Environmental and Molecular Mutagenesis. 29:303-311

The genotoxic potential of mainstream smoke from a test cigarette (TOB-HT) that primarily heats tobacco and a representative tobacco-burning cigarette (Kentucky reference 1R4F) was compared in male B6C3/F1 mice after nose-only inhalation exposure. Mi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::17605529c12896713d3034176e93fece
https://doi.org/10.1002/(sici)1098-2280(1997)29:3<303::aid-em11>3.0.co

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Effect of pH of the T4 Polynucleotide Kinase Reaction on the 32P-Postlabeling Assay of DNA Adducts

Autor: B.G. Brown, Chin K. Lee, B.R. Bombick, D.J. Doolittle

Publikováno v: Analytical Biochemistry. 227:156-161

Among the currently available methods for detecting bulky hydrophobic compounds bound to DNA, the 32P-postlabeling is the most sensitive and most widely practiced. One of the key reaction steps of this assay is the polynucleotide kinase (PNK)-catalyz

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8926cfe6aa97ec29c699de85e0eb5359
https://doi.org/10.1006/abio.1995.1265

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DNA adduct formation in mice following dermal application of smoke condensates from cigarettes that burn or heat tobacco

Autor: A. W. Hayes, Arnold T. Mosberg, M. Hejtmancik, E. A. Reed, Chin K. Lee, B. C. Brown, David J. Doolittle

Publikováno v: Environmental and Molecular Mutagenesis. 20:313-319

A prototype cigarette that heats tobacco (test cigarette), developed by R.J. Reynolds Tobacco Company, has yielded consistently negative results in several in vivo and in vitro genetic toxicology tests. The objective of the present study was to evalu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78746a6245393554c6f97f56d761d54c
https://doi.org/10.1002/em.2850200410

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The effect of exposure to nicotine, carbon monoxide, cigarette smoke or cigarette smoke condensate on the mutagenicity of rat urine

Autor: Carolyn A. Rahn, Chin K. Lee, David J. Doolittle

Publikováno v: Mutation Research/Genetic Toxicology. 260:9-18

Cigarette smokers have been reported to void urine which is more mutagenic than that voided by non-smokers, but the specific urinary mutagen(s) have not been identified. Since mechanistic studies are best performed in animal models, the objective of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe19ec5ad0a147e9e5bf108343272293
https://doi.org/10.1016/0165-1218(91)90075-w

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Comparative genotoxicity testing of mainstream whole smoke from cigarettes which burn or heat tobacco

Autor: Gary T. Burger, Chin K. Lee, David J. Doolittle, A. Wallace Hayes

Publikováno v: Mutation Research/Genetic Toxicology. 242:37-45

The genotoxic potential of mainstream whole smoke (MWS) from cigarettes which heat tobacco (TEST) was compared to the genotoxic potential of MWS from a cigarette which burns tobacco (REFERENCE). MWS was collected from a University of Kentucky 1R4F ci

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68c1b35ab0df21df1585c1c18547d867
https://doi.org/10.1016/0165-1218(90)90097-l

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Analysis of cytogenetic effects in bone-marrow cells of rats subchronically exposed to smoke from cigarettes which burn or only heat tobacco

Autor: Cindy Fulp, Paul H. Ayres, Susan C. McKarns, Grayland D. Lowe, Elizabeth A. Reed, Christopher R. E. Coggins, Chin K. Lee, Buddy G. Brown, David J. Doolittle

Publikováno v: Mutation Research/Genetic Toxicology. 240:251-257

The genotoxic effects of 90-day nose-only exposures to smoke from new cigarettes, which heat but do not burn tobacco (New), or from reference cigarettes, which burn tobacco, were evaluated in Sprague-Dawley rats by examining the cytogenetic endpoints

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e72aa08c4f1411a4c90da8efac371563
https://doi.org/10.1016/0165-1218(90)90075-d

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Genetic toxicology studies comparing the activity of sidestream smoke from cigarettes which burn or only heat tobacco

Autor: J. L. Ivett, C. J. Rudd, Jon C. Mirsalis, Gary T. Burger, David J. Doolittle, Edward S. Riccio, A.W. Hayes, Chin K. Lee

Publikováno v: Mutation Research/Genetic Toxicology. 240:59-72

The results of in vitro genetic toxicology studies of sidestream cigarette smoke (SSCS) from cigarettes which heat but do not burn tobacco were compared to those of sidestream smoke from cigarettes which burn tobacco. SSCSs from 5 cigarettes were com

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79228a286e5b553cf7fd692e492b0ff9
https://doi.org/10.1016/0165-1218(90)90008-p

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