Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Chimno I Nnadi"'
Autor:
David Mavor, Kyle Barlow, Samuel Thompson, Benjamin A Barad, Alain R Bonny, Clinton L Cario, Garrett Gaskins, Zairan Liu, Laura Deming, Seth D Axen, Elena Caceres, Weilin Chen, Adolfo Cuesta, Rachel E Gate, Evan M Green, Kaitlin R Hulce, Weiyue Ji, Lillian R Kenner, Bruk Mensa, Leanna S Morinishi, Steven M Moss, Marco Mravic, Ryan K Muir, Stefan Niekamp, Chimno I Nnadi, Eugene Palovcak, Erin M Poss, Tyler D Ross, Eugenia C Salcedo, Stephanie K See, Meena Subramaniam, Allison W Wong, Jennifer Li, Kurt S Thorn, Shane Ó Conchúir, Benjamin P Roscoe, Eric D Chow, Joseph L DeRisi, Tanja Kortemme, Daniel N Bolon, James S Fraser
Publikováno v:
eLife, Vol 5 (2016)
Ubiquitin is essential for eukaryotic life and varies in only 3 amino acid positions between yeast and humans. However, recent deep sequencing studies indicate that ubiquitin is highly tolerant to single mutations. We hypothesized that this tolerance
Externí odkaz:
https://doaj.org/article/f3e8373dbc7b4012a1c82425c9fb49fb
Autor:
Daniel Gentile, Meredith L. Jenkins, Kevan M. Shokat, John E. Burke, Nir London, Daniel K. Nomura, Leslie A. Bateman, Chimno I Nnadi, Daniel Zaidman, Trent E. Balius
Publikováno v:
Journal of chemical information and modeling, vol 58, iss 2
The success of targeted covalent inhibitors in the global pharmaceutical industry has led to a resurgence of covalent drug discovery. However, covalent inhibitor design for flexible binding sites remains a difficult task due to a lack of methodologic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e246e8a4b9a1dde427eae062510acc24
https://escholarship.org/uc/item/95j8d04k
https://escholarship.org/uc/item/95j8d04k
Autor:
Clinton L. Cario, Seth D. Axen, Weiyue Ji, Kurt S. Thorn, Adolfo Cuesta, Daniel N. Bolon, Kaitlin R. Hulce, Kyle A. Barlow, Marco Mravic, Jennifer X. Li, Lillian R. Kenner, Garrett Gaskins, Eugenia C Salcedo, Elena L. Caceres, David Mavor, Stefan Niekamp, Allison W. Wong, Weilin Chen, Bruk Mensa, Samuel Thompson, Benjamin A Barad, Erin M. Poss, Ryan K Muir, Rachel E. Gate, Laura Deming, Zairan Liu, Shane Ó Conchúir, Joseph L. DeRisi, Meena Subramaniam, James S. Fraser, Evan M. Green, Eugene Palovcak, Tanja Kortemme, Tyler D Ross, Alain R Bonny, Steven M. Moss, Stephanie K. See, Chimno I Nnadi, Benjamin P. Roscoe, Leanna S. Morinishi, Eric D. Chow
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::93a8a47dec29f83dc18d99f9ad48e8e5
https://doi.org/10.7554/elife.15802.023
https://doi.org/10.7554/elife.15802.023
Autor:
Marco Mravic, Chimno I Nnadi, Weiyue Ji, Benjamin P. Roscoe, Benjamin A Barad, Clinton L. Cario, Meena Subramaniam, Bruk Mensa, Ryan K Muir, Weilin Chen, Jennifer X. Li, Leanna S. Morinishi, Adolfo Cuesta, Daniel N. Bolon, Garrett Gaskins, Rachel E. Gate, Lillian R. Kenner, Kyle A. Barlow, Stefan Niekamp, Allison W. Wong, Tanja Kortemme, Eric D. Chow, Alain R Bonny, Joseph L. DeRisi, Zairan Liu, Shane Ó Conchúir, Kurt S. Thorn, Samuel Thompson, Seth D. Axen, Eugenia C Salcedo, Stephanie K. See, Kaitlin R. Hulce, Erin M. Poss, Elena L. Caceres, James S. Fraser, Eugene Palovcak, Laura Deming, David Mavor, Tyler D Ross, Evan M. Green, Steven M. Moss
Publikováno v:
eLife
eLife, Vol 5 (2016)
eLife, Vol 5 (2016)
Ubiquitin is essential for eukaryotic life and varies in only 3 amino acid positions between yeast and humans. However, recent deep sequencing studies indicate that ubiquitin is highly tolerant to single mutations. We hypothesized that this tolerance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b3aa255e8efa144b140b0f3d04b5bbc
http://europepmc.org/articles/PMC4862753
http://europepmc.org/articles/PMC4862753
Autor:
Chimno I. Nnadi, Mark J. S. Kelly, Robert J. Fletterick, Danica Galonić Fujimori, Idelisse Ortiz Torres, Kristopher M. Kuchenbecker
Publikováno v:
Nature communications, vol 6, iss 1
The retinoblastoma binding protein KDM5A removes methyl marks from lysine 4 of histone H3 (H3K4). Misregulation of KDM5A contributes to the pathogenesis of lung and gastric cancers. In addition to its catalytic jumonji C domain, KDM5A contains three
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e14a75281a57a1f79d3df0a49a03ecc2
https://pubmed.ncbi.nlm.nih.gov/25686748
https://pubmed.ncbi.nlm.nih.gov/25686748