Zobrazeno 1 - 10
of 66
pro vyhledávání: '"Chimie médicinale"'
Autor:
Flynn-Robitaille, Joël
Problématique : Le cancer du sein est un des types du cancer les plus diagnostiqués au Canada et il est une cause majeure de mortalité liée au cancer chez la femme. Le cancer du sein triple négatif (CSTN) a un mauvais pronostic dû à son agress
Externí odkaz:
http://hdl.handle.net/1866/28072
Autor:
MacDougall, Thomas
Les relations entre la structure des composés chimiques et leurs propriétés sont complexes et à haute dimension. Dans le processus de développement de médicaments, plusieurs proprié- tés d’un composé doivent souvent être optimisées simul
Autor:
Jourdain de Muizon, Capucine
This manuscript describes the chemical and biological studies carried out on the nacre of pearl oysters and marine calcareous sponges. The main objective was to identify new osteogenic compounds.Nacre is a mineral biocompatible and osteoinductive mat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______166::e4ea54e9740b7366139a8548166ce62a
https://theses.hal.science/tel-03945776
https://theses.hal.science/tel-03945776
Autor:
Ait Amiri, Sabrina
Publikováno v:
Biochimie, Biologie Moléculaire. Sorbonne Université, 2021. Français. ⟨NNT : 2021SORUS064⟩
KLK6 and KLK8 are serine proteases (SP) essential for central nervous system homeostasis and whose activities are deregulated in multiple sclerosis (MS). The development of inhibitors of KLK6 and KLK8 constitutes a promising therapeutic avenue and th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______1398::95b792a02d8885655b0d6708acad70e3
https://theses.hal.science/tel-03585528/document
https://theses.hal.science/tel-03585528/document
Autor:
Mourot, Laura
Despite significant progress in the control of malaria with a net reduction of morbidity and mortality in recent years, in particular thanks to better diagnosis, increasing use of mosquito nets and improved access to healthcare, malaria remains one o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______166::29f7bb746fa559fbe437b16dfecd164c
https://theses.hal.science/tel-03677894
https://theses.hal.science/tel-03677894
Autor:
Yvorra, Thomas
Publikováno v:
Medicinal Chemistry. Université Paris sciences et lettres, 2020. English. ⟨NNT : 2020UPSLT011⟩
MAIT cells are innate-like T lymphocytes that recognize a series of microbial antigens derived from the riboflavin (vitamin B2) biosynthesis pathway, which are exclusively present in bacteria and some yeasts. The TCR dependent activation of MAIT cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::ffa39b0f97ab02bcbf4364efd0c963c6
https://tel.archives-ouvertes.fr/tel-03200069/document
https://tel.archives-ouvertes.fr/tel-03200069/document
Autor:
Le Bescont, Julie
Publikováno v:
Chimie organique. Université Paris-Saclay, 2020. Français. ⟨NNT : 2020UPASF016⟩
The TAM family consists in 3 tyrosine kinases : Tyro3, Axl and Mer. These proteins are involved in many cellular processes and pathways. The TAM family has been identified as a new promising target for cancer therapy, autoimmune diseases and viral in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______2592::2bd77d80c302707a61bd90c3deb008c0
https://tel.archives-ouvertes.fr/tel-03092007
https://tel.archives-ouvertes.fr/tel-03092007
Autor:
Juillet, Charlotte
Publikováno v:
Chimie thérapeutique. Université Paris-Saclay, 2020. Français. ⟨NNT : 2020UPASF019⟩
This manuscript describes the design, synthesis and biological evaluation of oroidin analogs. Oroidin is a monomer of benzosceptrin C, belonging to the pyrrole-2-aminoimidazole family, isolated from marine sponges. The simplification and structural d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::96360b6832f7b305d520638bcba47b66
https://theses.hal.science/tel-02992052
https://theses.hal.science/tel-02992052
Autor:
Laurent, Arthur
Endothelin is a peptide product by endothelial cells which interacts with two G protein coupled receptors, ETA et ETB. It’s involved in a numerous of pathophysiological processes, especially into the vascular system. Its role in vascular tone regul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______2592::e7302d33e178dca563901d62c6d78c1a
https://dumas.ccsd.cnrs.fr/dumas-02497130
https://dumas.ccsd.cnrs.fr/dumas-02497130
Autor:
Rosales Hurtado, Miyanou
Publikováno v:
Chimie organique. Université de Nîmes, 2019. Français. ⟨NNT : 2019NIME0003⟩
Chimie thérapeutique. Université de Nîmes, 2019. Français. ⟨NNT : 2019NIME0003⟩
Chimie thérapeutique. Université de Nîmes, 2019. Français. ⟨NNT : 2019NIME0003⟩
The recent and persistent emergence of antibiotic-resistant bacterial strains, typically used clinically, is a serious public health problem. This is all the more accentuated by the misuse of antibiotics. It is therefore urgent to find new antibacter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::12b4141de54d4e6a51228fd907cf78a6
https://tel.archives-ouvertes.fr/tel-02976570
https://tel.archives-ouvertes.fr/tel-02976570