Zobrazeno 1 - 10
of 3 292
pro vyhledávání: '"Chimeric antigen receptor T-cell"'
Autor:
Daniel H. Chen, Maeve O'Reilly, Kathleen P. Cheok, Ryan Low, Rajesh Puranik, Samuel Clark, John Malcolm Walker, Charlotte Manisty, Arjun K. Ghosh, Claire Roddie
Publikováno v:
eJHaem, Vol 5, Iss 6, Pp 1283-1289 (2024)
Abstract Introduction Chimeric antigen receptor T‐cell (CAR‐T) therapy is highly effective in B‐cell blood cancers, but there is limited data on its safety and efficacy in intra‐cardiac lymphoma, due to the potential risks of cardiotoxicity a
Externí odkaz:
https://doaj.org/article/0617db4ddb0a419c84e7c492e3415f1b
Publikováno v:
Biomarker Research, Vol 12, Iss 1, Pp 1-36 (2024)
Abstract The application of chimeric antigen receptor T-cell therapy in central nervous system tumors has significantly advanced; however, challenges pertaining to the blood-brain barrier, immunosuppressive microenvironment, and antigenic heterogenei
Externí odkaz:
https://doaj.org/article/60954a8e09d34cf2a8244022f988b5b1
Autor:
Songnan Sui, Mengjun Zhong, Shuxin Zhong, Xueting Peng, Lipeng Mao, Cunte Chen, Chengwu Zeng, Oscar Junhong Luo, Yangqiu Li
Publikováno v:
Biomarker Research, Vol 12, Iss 1, Pp 1-16 (2024)
Abstract Background Exhaustion is a key factor that influences the efficacy of chimeric antigen receptor T (CAR-T) cells. Our previous study demonstrated that a bromodomain protein 4 (BRD4) inhibitor can revise the phenotype and function of exhausted
Externí odkaz:
https://doaj.org/article/4ffb6b26b2d74680b653b6d87757a4c9
Publikováno v:
Journal of Ovarian Research, Vol 17, Iss 1, Pp 1-21 (2024)
Abstract Ovarian cancer, often referred to as the “silent killer,” is notoriously difficult to detect in its early stages, leading to a poor prognosis for many patients. Diagnosis is often delayed until the cancer has advanced, primarily due to i
Externí odkaz:
https://doaj.org/article/27ce0c22a5cb4ddc8eb5304d7b6146e5
Autor:
Orla McCourt, Paul Maciocia, Claire Roddie, Angela Hwang, Leigh Wood, Aikaterini Panopoulou, Deborah Ann Springell, Maise Al Bakir, Maeve O'Reilly
Publikováno v:
eJHaem, Vol 5, Iss 5, Pp 1033-1037 (2024)
Abstract Introduction This report outlines the evaluation of physiotherapist‐led prehabilitation/rehabilitation for recipients of chimeric antigen receptor T (CAR‐T) cell therapy. Methods A hybrid approach was used, incorporating in‐person asse
Externí odkaz:
https://doaj.org/article/6bd3cfb7d68a4538b79ef361cacaa10c
Autor:
Esther Choi, BS, Cuong V. Nguyen, MD
Publikováno v:
JAAD Case Reports, Vol 52, Iss , Pp 42-45 (2024)
Externí odkaz:
https://doaj.org/article/c328054274a048bab92adc7b39b774c4
Publikováno v:
Stem Cell Research & Therapy, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Background Chimeric antigen receptor (CAR)-T therapy has emerged as a promising treatment for hematologic malignancies. However, cytopenia remains one of the most frequent and challenging adverse effects of this therapy. Methods We conducted
Externí odkaz:
https://doaj.org/article/d3c85e66332f47c3b2f0ba5e50178e89
Publikováno v:
Journal of Hematology & Oncology, Vol 17, Iss 1, Pp 1-19 (2024)
Abstract Given its nearly ubiquitous expression on plasma cells and limited expression on essential normal tissue, the G protein-coupled receptor class C group 5 member D (GPRC5D) presents a promising opportunity for utilization as an immunotherapy t
Externí odkaz:
https://doaj.org/article/b4b2d848e2a5405c903b6328a7211437
Publikováno v:
陆军军医大学学报, Vol 46, Iss 17, Pp 1951-1958 (2024)
Objective To use superparamagnetic iron oxide nanoparticles (SPIONs) to label chimeric antigen receptor (CAR) T cells targeting carcinoembryonic antigen (CEA), and perform magnetic resonance imaging (MRI) to real time trace CEA CAR-T cells in vivo. M
Externí odkaz:
https://doaj.org/article/82f0ee9c17b44669b1d55df548b5b1a5
Publikováno v:
Journal of Hematology & Oncology, Vol 17, Iss 1, Pp 1-4 (2024)
Abstract Multiple classes of therapies targeting claudin-18 isoform 2 (CLDN18.2) are under development for the treatment of advanced gastroesophageal adenocarcinoma and other solid tumors. At the 2024 American Society of Clinical Oncology (ASCO) Annu
Externí odkaz:
https://doaj.org/article/7c852dae49844599adeca9f938191bc2