Zobrazeno 1 - 10
of 851
pro vyhledávání: '"Chimeric antibody"'
Publikováno v:
Shanghai Jiaotong Daxue xuebao. Yixue ban, Vol 43, Iss 6, Pp 718-727 (2023)
Objective·To screen the human-mouse chimeric antibodies that neutralize the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and analyse the key amino acid site changes in their light chain.Methods·Antibody heavy chain gene-humanized m
Externí odkaz:
https://doaj.org/article/8e6ffb69cc984a36936074554f1a08c2
Akademický článek
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Autor:
Lixuan Zhou, Hongchao Wu, Mengmeng Du, Huanhuan Song, Ningning Huo, Xiao Chen, Xiaorui Su, Weiguo Li, Lulu Wang, Jie Wang, Baicheng Huang, Feifei Tan, Kegong Tian
Publikováno v:
AMB Express, Vol 12, Iss 1, Pp 1-9 (2022)
Key points A canine-derived chimeric MAb 11D9 was produced by CHO cell lines. The MAb 11D9 exhibited high HI and neutralization titers against new CPV-2 variants. The MAb 11D9 had a high therapeutic effect in beagles infected with the new CPV-2a vari
Externí odkaz:
https://doaj.org/article/cdc9b8f4d2864d7b803a2375c213571e
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Recent advances in the development of therapeutic antibodies (Abs) have greatly improved the treatment of otherwise drug-resistant cancers and autoimmune diseases. Antibody activities are mediated by both their Fab and the Fc. However, therapeutic Ab
Externí odkaz:
https://doaj.org/article/ce8a4736796f4b36983e0ff2cb7d0b54
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
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Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 20, p 12358 (2022)
Ovarian cancer is the fifth leading cause of cancer, followed by front line is mostly platinum agents and PARP inhibitors, and very limited option in later lines. Therefore, there is a need for alternative therapeutic options. Nectin-2, which is over
Externí odkaz:
https://doaj.org/article/78991ca348064d68a12a607e7f0e2086
Autor:
Andrey L. Matveev, Irina V. Kozlova, Elena K. Doroshchenko, Oleg V. Stronin, Oksana V. Lisak, Olga V. Suntsova, Yulia S. Savinova, Lyudmila A. Emelyanova, Ivan K. Baykov, Nina V. Tikunova
Publikováno v:
Acta Biomedica Scientifica, Vol 4, Iss 1, Pp 143-149 (2019)
Tick-borne encephalitis virus (TBEV), belonging to the Flaviviridae family, is the most significant pathogen transmitted by Ixodes ticks and causing one of the most severe human neuroinfections. In Russia, serum immunoglobulin produced from the donor
Externí odkaz:
https://doaj.org/article/56a245efbbbb4a9b859d177ec2ad5582
Autor:
Guanjie Li, Tomokazu Ohishi, Mika K. Kaneko, Junko Takei, Takuya Mizuno, Manabu Kawada, Masaki Saito, Hiroyuki Suzuki, Yukinari Kato
Publikováno v:
Cells, Vol 10, Iss 12, p 3599 (2021)
The epidermal growth factor receptor (EGFR) contributes to tumor malignancy via gene amplification and protein overexpression. Previously, we developed an anti-human EGFR (hEGFR) monoclonal antibody, namely EMab-134, which detects hEGFR and dog EGFR
Externí odkaz:
https://doaj.org/article/b4584176140744e8a74f598e78bd78bf
Autor:
S M Gheibi hayat, AH Sahebkar
Publikováno v:
Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, Vol 19, Iss 7, Pp 20-27 (2017)
BACKGROUND AND OBJECTIVE: In recent decades, the use of antibody drugs conjugates (ADCs) generated promise for the treatment of cancer. In this type of treatment, a monoclonal antibody against a cancer specific antigen is used, and a cytotoxic drug i
Externí odkaz:
https://doaj.org/article/94b18ed328f242dda0d5ade4e1b61b92
Autor:
Mika K. Kaneko, Shinji Yamada, Takuro Nakamura, Shinji Abe, Yasuhiko Nishioka, Akiko Kunita, Masashi Fukayama, Yuki Fujii, Satoshi Ogasawara, Yukinari Kato
Publikováno v:
Cancer Medicine, Vol 6, Iss 4, Pp 768-777 (2017)
Abstract Human podoplanin (hPDPN), a platelet aggregation‐inducing transmembrane glycoprotein, is expressed in different types of tumors, and it binds to C‐type lectin‐like receptor 2 (CLEC‐2). The overexpression of hPDPN is involved in invas
Externí odkaz:
https://doaj.org/article/f64aafaa15d94144a962e413ae1ea3d0