Zobrazeno 1 - 10
of 4 219
pro vyhledávání: '"Chimera (genetics)"'
Publikováno v:
Trends in Cancer. 8:123-134
Engineered T cell therapies, mainly chimeric antigen receptor (CAR)-T and T cell receptor (TCR)-T, have become the new frontier of cancer treatment. CAR-T and TCR-T therapies differ in many aspects, including cell persistence and toxicity, leading to
Publikováno v:
Journal of Thrombosis and Haemostasis. 20:208-221
BACKGROUND Tissue dynamics of von Willebrand factor (VWF) that are vital to its biological function have not been fully characterized. OBJECTIVE To develop a new fluorescent protein--VWF chimera (FP-VWF) that has similar hematologic function to wild-
Publikováno v:
Nuclear Medicine and Biology. :28-37
Introduction Prostate-specific membrane antigen (PSMA) is highly expressed in prostate cancer (PCa). The aptamer (Apt) A10-3.2 can be used as a specific ligand for the early diagnosis and targeted treatment of PCa. siRNA-Apt has been used to therapeu
Publikováno v:
Известия высших учебных заведений: Прикладная нелинейная динамика, Vol 29, Iss 6, Pp 943-952 (2021)
The aim of the research is to study the influence of inhomogeneity in a control parameter of all partial elements in a ring of nonlocally coupled chaotic maps on the possibility of observing chimera states in the system and to compare the changes in
Publikováno v:
Applied Biochemistry and Biotechnology. 194:1636-1644
Sea lamprey immunization can yield leucine-rich repeat (LRR) protein binders analogous to globular antibodies developed from mammals. A novel minimal LRR was discovered through lamprey immunization with human immunoglobulin G Fc domain (IgG Fc). Init
Autor:
Kristóf Ferentzi, Kim Hoang Yen Duong, Viktória Goldschmidt Gőz, András Perczel, Dániel Horváth, Viktor Farkas
Publikováno v:
European Journal of Organic Chemistry. 2021:6071-6083
Autor:
Cheng-Feng Qin, Yongchun Li, Fei Yuan, Jiankai Liu, Jianguo Zhao, Shujun Liu, Aihua Zheng, Junfeng Hao, Chaoyue Zhao, Hongyue Li, Yong-Qiang Deng, Dan Wen, Dong Li, Yuhang Zhang, Hongde Xu, Shuguang Duo, Jiandong Liu, Yong Wu
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 6, Iss 1, Pp 1-12 (2021)
Signal Transduction and Targeted Therapy
Signal Transduction and Targeted Therapy
SARS-CoV-2 and SARS-CoV are genetically related coronavirus and share the same cellular receptor ACE2. By replacing the VSV glycoprotein with the spikes (S) of SARS-CoV-2 and SARS-CoV, we generated two replication-competent recombinant viruses, rVSV-
Autor:
Rodrigo Barros de Pinho, Rafael Danelon dos Santos Woloski, Mirna Samara Dié Alves, Nicole Ramos Scholl, Mara Thais de Oliveira Silva, Francisco Silvestre Brilhante Bezerra, Sibele Borsuk, Luiza Domingues Moron, Frederico Schmitt Kremer
Publikováno v:
Applied Microbiology and Biotechnology
Caseous lymphadenitis (CLA) is an infectious disease that affects goats and sheep causing drastic impacts on milk and meat production and is caused by Corynebacterium pseudotuberculosis. The disease can be prevented through vaccination but currently,
Autor:
Bishal Marasini, Akil Akhtar, Samir K. Lakhashe, Dinesh Hariraju, Ruth M. Ruprecht, Sarah J. Ratcliffe, Hemant K. Vyas
Publikováno v:
AIDS (London, England)
Objective Antibody-dependent enhancement (ADE) affects host-virus dynamics in fundamentally different ways: i) enhancement of initial virus acquisition, and/or ii) increased disease progression/severity. Here we address the question whether anti-HIV-
Autor:
Heng Zhang, Feng Lin, Jian Lin, Yu Han, Kexin Li, Linghao Kong, Yuan-Fan Yang, Peng Chen, Yongjun Dang, Hongxiang Liu
Publikováno v:
Journal of the American Chemical Society. 143:16377-16382
The targeted degradation of membrane proteins would afford an attractive and general strategy for treating various diseases that remain difficult with the current proteolysis-targeting chimera (PROTAC) methodology. We herein report a covalent nanobod