Frailty before and during austerity: A time series analysis of the English Longitudinal Study of Ageing 2002-2018.

Autor: Carys Pugh, Chima Eke, Sohan Seth, Bruce Guthrie, Alan Marshall

Publikováno v: PLoS ONE, Vol 19, Iss 2, p e0296014 (2024)

BackgroundFrailty is characterised by a reduced resilience to adversity. In this analysis we examined changes in frailty in people aged 50+ before and during a period of austere public spending in England.MethodsData from the English Longitudinal Stu

Externí odkaz: https://doaj.org/article/0dd22f388a65415987604756ec0bd694

Effect of competing mortality risks on predictive performance of the QFracture risk prediction tool for major osteoporotic fracture and hip fracture:external validation cohort study in a UK primary care population

Autor: Shona J Livingstone, Daniel R Morales, Megan McMinn, Chima Eke, Peter Donnan, Bruce Guthrie

Publikováno v: Livingstone, S J, Morales, D R, McMinn, M, Eke, C, Donnan, P T & Guthrie, B 2022, ' Effect of competing mortality risks on predictive performance of the QFracture risk prediction tool for major osteoporotic fracture and hip fracture : external validation cohort study in a UK primary care population ', BMJ Medicine, vol. 1, no. 1, e000316 . https://doi.org/10.1136/bmjmed-2022-000316

ObjectiveTo externally evaluate the QFracture risk prediction tool for predicting the risk of major osteoporotic fracture and hip fracture.DesignExternal validation cohort study.SettingUK primary care population. Linked general practice (Clinical Pra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e23dbc6aee4931d48a61dbf89fc9e44
https://www.pure.ed.ac.uk/ws/files/310582474/e000316.full.pdf

Integrated stress responses in okra plants (cv. ‘’Meya’]: unravelling the mechanisms underlying drought and nematode co-occurrence

Autor: Uchenna Egedigwe, Obi Udengwu, Chima Ekeleme-Egedigwe, Chima Maduakor, Clifford Urama, Chidera Odo, Eugene Ojua

Publikováno v: BMC Plant Biology, Vol 24, Iss 1, Pp 1-18 (2024)

Abstract Background Climate change threatens sub-Saharan Africa’s agricultural production, causing abiotic and biotic stressors. The study of plant responses to joint stressors is crucial for understanding molecular processes and identifying resili

Externí odkaz: https://doaj.org/article/88757b8cf3994230887064a4a61a9e4c

Morin hydrate downregulates inflammation‐mediated nitric oxide overproduction and potentiates antioxidant mechanism against anticancer drug doxorubicin oxidative hepatorenal toxicity in rats

Autor: Ademola Famurewa, Chima Ekeleme-Egedigwe, Patience Ogbu, Ayodeji Ajibare, Moshood Folawiyo, Doris Obasi, Arunaksharan Narayanankutty

Publikováno v: Avicenna Journal of Phytomedicine, Vol 13, Iss 5, Pp 475-487 (2023)

Objective: Doxorubicin (DOX) is a frontline antineoplastic drug that kills cancer cells through genotoxic mechanism; however, it induces organ toxicities. This study assayed whether morin hydrate (MOH) could abrogate DOX hepatorenal toxicity in rats.

Externí odkaz: https://doaj.org/article/2bf26b4a167e408fbb94784aa5558116

Nephroprotective activity of virgin coconut oil on diclofenac-induced oxidative nephrotoxicity is associated with antioxidant and anti-inflammatory effects in rats

Autor: Ademola Famurewa, Gabriel Akunna, Joseph Nwafor, Onyebuchi Chukwu, Chima Ekeleme-Egedigwe, Janet Oluniran

Publikováno v: Avicenna Journal of Phytomedicine, Vol 10, Iss 3, Pp 316-324 (2020)

Objective: Diclofenac is a non-steroidal anti-inflammatory drug linked with considerable organ toxicity caused via increased generation of reactive oxygen species. We evaluated whether the antioxidant effect of virgin coconut oil (VCO) could prevent

Externí odkaz: https://doaj.org/article/c74162dfab064a06b8f327986143ac57