Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Chim Kei Chan"'
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Wnt signaling functions in tissue homeostasis and tumorigenesis. Here the authors show that ROR2, a Wnt receptor, plays roles not only in transducing Wnt signaling, but also in regulation of DNA damage response critical for stem cell maintenance.
Externí odkaz:
https://doaj.org/article/b383d716f786422a92e3bc8bc8deba52
Publikováno v:
Journal of Functional Foods, Vol 38, Iss , Pp 221-231 (2017)
Microglial activation which results in neuroinflammation, plays a great significance in the pathogenesis of neurodegenerative diseases by secreting various neurotoxic factors. Suppression of microglial activation by the natural-derived compounds may
Externí odkaz:
https://doaj.org/article/d7736d7cb80446ee9e991d0326ac67cb
Autor:
Kai-Ching Tay, Loh Teng-Hern Tan, Chim Kei Chan, Sok Lai Hong, Kok-Gan Chan, Wei Hsum Yap, Priyia Pusparajah, Learn-Han Lee, Bey-Hing Goh
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
Cancer, a complex yet common disease, is caused by uncontrolled cell division and abnormal cell growth due to a variety of gene mutations. Seeking effective treatments for cancer is a major research focus, as the incidence of cancer is on the rise an
Externí odkaz:
https://doaj.org/article/5137ca93efab49e5998c2bcdbfb33c37
Autor:
Hadi Supriady, Muhamad Noor Alfarizal Kamarudin, Chim Kei Chan, Bey Hing Goh, Habsah Abdul Kadir
Publikováno v:
Journal of Functional Foods, Vol 17, Iss , Pp 434-448 (2015)
The ethyl acetate fraction from the seeds of Swietenia macrophylla (SMEAF) was studied for anti-inflammatory properties using lipopolysaccharide (LPS)-induced BV-2 microglia. SMEAF significantly attenuated the LPS-induced production of nitric oxide (
Externí odkaz:
https://doaj.org/article/179c76e4acc9465b965c3ede4f622ae1
Publikováno v:
Cancers, Vol 11, Iss 9, p 1216 (2019)
The skin functions as a barrier between the organism and the surrounding environment. Direct exposure to external stimuli and the accumulation of genetic mutations may lead to abnormal cell growth, irreversible tissue damage and potentially favor ski
Externí odkaz:
https://doaj.org/article/234c894a18d640118642dd7bfa888c31
Autor:
Habsah Abdul Kadir, Tara Shabab, Chim Kei Chan, Soheil Zorofchian Moghadamtousi, Bey Hing Goh
Publikováno v:
Molecules, Vol 18, Iss 9, Pp 10465-10483 (2013)
Swietenia macrophylla King (Meliaceae) is an endangered and medicinally important plant indigenous to tropical and subtropical regions of the World. S. macrophylla has been widely used in folk medicine to treat various diseases. The review reveals th
Externí odkaz:
https://doaj.org/article/03f8ba2acc6d47d7beaf04129461e72f
Publikováno v:
Molecules, Vol 17, Iss 6, Pp 6633-6657 (2012)
The aim of this study was to investigate the cytotoxic and apoptotic effects of Nephelium ramboutan-ake (pulasan) rind in selected human cancer cell lines. The crude ethanol extract and fractions (ethyl acetate and aqueous) of N. ramboutan-ake inhibi
Externí odkaz:
https://doaj.org/article/5ad3d5a33a3948548a6c627dfced3139
Publikováno v:
Molecules, Vol 21, Iss 3, p 385 (2016)
Deoxyelephantopin (DET), one of the major sesquiterpene lactones derived from Elephantopus scaber was reported to possess numerous pharmacological functions. This study aimed to assess the apoptosis inducing effects and cell cycle arrest by DET follo
Externí odkaz:
https://doaj.org/article/df68a770af3e486890eb69829201f983
Publikováno v:
Asian Pacific Journal of Tropical Biomedicine, Vol 10, Iss 3, Pp 120-135 (2020)
Objective: To systematically map the stepwise events leading to deoxyelephantopin-induced cell death of HCT116 human colorectal cancer cells and evaluate the effectiveness of deoxyelephantopin in vivo. Methods: HCT116 cells were treated with deoxyele
Autor:
Loh Teng Hern Tan, Siah Ying Tang, Chim Kei Chan, Yong Sze Ong, Hefa Mangzira Kemung, Darren Yi Sern Low, Bey Hing Goh, Kooi Yeong Khaw
Publikováno v:
Progress In Microbes & Molecular Biology. 3
Biofilms form protective layers over bacteria that are associated with a majority of the hospital infections contributing to antibiotic resistance development in susceptible strains. Nowadays, there is a pressing need for developing effective anti-bi