Zobrazeno 1 - 10
of 56
pro vyhledávání: '"Chilman Bae"'
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 18 (2024)
Microglia are the resident macrophages of the central nervous system (CNS) that control brain development, maintain neural environments, respond to injuries, and regulate neuroinflammation. Despite their significant impact on various physiological an
Externí odkaz:
https://doaj.org/article/4d579cd2e5d24e57a7d4ed0e04e04d42
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 17 (2023)
Piezo1 mechanosensitive ion channel (MSC) plays a significant role in human physiology. Despite several research on the function and expression of Piezo1 in the nervous system, its electrophysiological properties in neuroinflammatory astrocytes remai
Externí odkaz:
https://doaj.org/article/275050b337524bafa8880c16cd2c7464
Autor:
Austin Kearns, Jazmine Jayasi, Xin Liu, Jigong Wang, Yuqiang Shi, Jin Mo Chung, Jun-Ho La, Shao-Jun Tang, Chilman Bae
Publikováno v:
Frontiers in Synaptic Neuroscience, Vol 13 (2021)
Opioids are widely used for pain relief; however, chronic opioid use causes a paradoxical state of enhanced pain sensitivity, termed “Opioid-induced hyperalgesia (OIH).” Despite the clinical importance of OIH, the detailed mechanism by which it e
Externí odkaz:
https://doaj.org/article/a985fcbed4b740049b7845885ae721ae
Autor:
Charles D. Cox, Chilman Bae, Lynn Ziegler, Silas Hartley, Vesna Nikolova-Krstevski, Paul R. Rohde, Chai-Ann Ng, Frederick Sachs, Philip A. Gottlieb, Boris Martinac
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
PIEZO1 is a mechanosensitive ion channel, but the mechanism of force transduction is unknown. Here Cox and Bae et al.disrupt the cortical cytoskeleton in HEK293 cells to show that PIEZO1 is gated directly by membrane tension.
Externí odkaz:
https://doaj.org/article/8bb6428e3a354f2a80b77e5eb08f7827
Publikováno v:
PLoS ONE, Vol 13, Iss 11, p e0207309 (2018)
PIEZO1 and PIEZO2 are mechanosensitive channels (MSCs) important for cellular function and mutations in them lead to human disorders. We examined how functional heteromers form between subunits of PIEZO1 using the mutants E2117K, E2117D, and E2117A.
Externí odkaz:
https://doaj.org/article/569bcb0c660447f9baf30f4189d3b3c0
Publikováno v:
PLoS ONE, Vol 11, Iss 3, p e0151289 (2016)
PIEZO1 is a mechanosensitive eukaryotic cation-selective channel that rapidly inactivates in a voltage-dependent manner. We previously showed that a fluorescent protein could be encoded within the hPIEZO1 sequence without loss of function. In this wo
Externí odkaz:
https://doaj.org/article/cb3209a747334edea5cc65bc15f82598
Publikováno v:
PLoS ONE, Vol 10, Iss 5, p e0125503 (2015)
Members of the eukaryotic PIEZO family (the human orthologs are noted hPIEZO1 and hPIEZO2) form cation-selective mechanically-gated channels. We characterized the selectivity of human PIEZO1 (hPIEZO1) for alkali ions: K+, Na+, Cs+ and Li+; organic ca
Externí odkaz:
https://doaj.org/article/0470e082561b4c6f9959640422473e33
Autor:
Chilman Bae, Peter J. Butler
Publikováno v:
BioTechniques, Vol 41, Iss 4, Pp 399-402 (2006)
Externí odkaz:
https://doaj.org/article/2162682638ac412c891c9c8a9bf48e12
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e72894 (2013)
Mutations that lead to muscular dystrophy often create deficiencies in cytoskeletal support of the muscle sarcolemma causing hyperactive mechanosensitive cation channel (MSC) activity and elevated intracellular Ca(2+). Caveolae are cholesterol-rich m
Externí odkaz:
https://doaj.org/article/adf9410c40e54898bddeaa0ad308a457
Publikováno v:
Biophysical Journal. 122:523a