Viral transduction of primary human lymphoma B cells reveals mechanisms of NOTCH-mediated immune escape

Autor: Mangolini, Maurizio, Maiques-Diaz, Alba, Charalampopoulou, Stella, Gerhard-Hartmann, Elena, Bloehdorn, Johannes, Moore, Andrew, Giachetti, Giorgia, Lu, Junyan, Roamio Franklin, Valar Nila, Chilamakuri, Chandra Sekkar Reddy, Moutsopoulos, Ilias, Rosenwald, Andreas, Stilgenbauer, Stephan, Zenz, Thorsten, Mohorianu, Irina, D'Santos, Clive, Deaglio, Silvia, Hodson, Daniel J, Martin-Subero, Jose I, Ringshausen, Ingo

Hotspot mutations in the PEST-domain of NOTCH1 and NOTCH2 are recurrently identified in B cell malignancies. To address how NOTCH-mutations contribute to a dismal prognosis, we have generated isogenic primary human tumor cells from patients with Chro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e11899aea8fad9f4ca973b6120f75a29

Viral transduction of primary human lymphoma B cells reveals mechanisms of NOTCH-mediated immune escape.

Autor: Mangolini M; Wellcome/MRC Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge, CB2 0AW, UK.; Department of Haematology, University of Cambridge, Cambridge, CB2 0AH, UK., Maiques-Diaz A; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain., Charalampopoulou S; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain., Gerhard-Hartmann E; Pathologisches Institut Universität Würzburg, 97080, Würzburg, Germany., Bloehdorn J; Department of Internal Medicine III, Division of CLL, Ulm University, Ulm, Germany., Moore A; Wellcome/MRC Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge, CB2 0AW, UK.; Department of Haematology, University of Cambridge, Cambridge, CB2 0AH, UK., Giachetti G; Wellcome/MRC Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge, CB2 0AW, UK.; Department of Haematology, University of Cambridge, Cambridge, CB2 0AH, UK., Lu J; European Molecular Biology Laboratory (EMBL), Heidelberg, Germany.; Molecular Medicine Partnership Unit (MMPU), Heidelberg, Germany., Roamio Franklin VN; Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK., Chilamakuri CSR; Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK., Moutsopoulos I; Wellcome/MRC Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge, CB2 0AW, UK., Rosenwald A; Pathologisches Institut Universität Würzburg, 97080, Würzburg, Germany., Stilgenbauer S; Department of Internal Medicine III, Division of CLL, Ulm University, Ulm, Germany., Zenz T; Department of Medical Oncology and Hematology, University Hospital Zürich and University of Zürich, Zürich, Switzerland.; Molecular Therapy in Hematology and Oncology, National Center for Tumor Diseases and German Cancer, Research Centre, Heidelberg, Germany., Mohorianu I; Wellcome/MRC Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge, CB2 0AW, UK., D'Santos C; Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK., Deaglio S; Department of Medical Sciences, University of Turin, Turin, Italy., Hodson DJ; Wellcome/MRC Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge, CB2 0AW, UK.; Department of Haematology, University of Cambridge, Cambridge, CB2 0AH, UK., Martin-Subero JI; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.; Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain., Ringshausen I; Wellcome/MRC Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge, CB2 0AW, UK. ir279@cam.ac.uk.; Department of Haematology, University of Cambridge, Cambridge, CB2 0AH, UK. ir279@cam.ac.uk.

Publikováno v: Nature communications [Nat Commun] 2022 Oct 20; Vol. 13 (1), pp. 6220. Date of Electronic Publication: 2022 Oct 20.