Clinical Association of Achilles Tendinopathy and Hypertension Mediated by CaV1.2 Voltage-gated Ca2+ Channel

Autor: David J. Ciufo MD, Chike Cao PhD, Christopher Mendias PhD, ATC, Haiyin Li MD, PhD

Publikováno v: Foot & Ankle Orthopaedics, Vol 8 (2023)

Category: Basic Sciences/Biologics; Hindfoot Introduction/Purpose: The Achilles tendon is subject to acute- and overuse-injuries, which may result in degenerative tendinopathy. Achilles tendinopathy is associated with pain, disability, and functional

Externí odkaz: https://doaj.org/article/534f9d7f096f46ce8205b479b48239dc

Polyester Modification of the Mammalian TRPM8 Channel Protein: Implications for Structure and Function

Autor: Chike Cao, Yevgen Yudin, Yann Bikard, Wei Chen, Tong Liu, Hong Li, Dieter Jendrossek, Alejandro Cohen, Evgeny Pavlov, Tibor Rohacs, Eleonora Zakharian

Publikováno v: Cell Reports, Vol 4, Iss 2, Pp 302-315 (2013)

The TRPM8 ion channel is expressed in sensory neurons and is responsible for sensing environmental cues, such as cold temperatures and chemical compounds, including menthol and icilin. The channel functional activity is regulated by various physical

Externí odkaz: https://doaj.org/article/b71b0dc9c68c46f78119db6e3547693a

Voltage-Gated Calcium Channels in Nonexcitable Tissues

Autor: Chike Cao, Geoffrey S. Pitt, Maiko Matsui

Publikováno v: Annu Rev Physiol

The identification of a gain-of-function mutation in CACNA1C as the cause of Timothy syndrome, a rare disorder characterized by cardiac arrhythmias and syndactyly, highlighted roles for the L-type voltage-gated Ca2+ channel CaV1.2 in nonexcitable cel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5c0ca518f01ef3e61c6fa49184cc9b0
https://doi.org/10.1146/annurev-physiol-031620-091043

The Ca(V)1.2 L-type calcium channel regulates bone homeostasis in the middle and inner ear

Autor: Yinshi Ren, Chike Cao, George Trainor, Ramona M. Rodriguiz, Geoffrey S. Pitt, Brian A. Fabella, Aaron Oswald, Matthew B. Greenblatt, Matthew J. Hilton

Publikováno v: Bone

Bone remodeling of the auditory ossicles and the otic capsule is highly restricted and tightly controlled by the osteoprotegerin (OPG) / receptor activator of nuclear factor kappa-B ligand (RANKL) / receptor activator of nuclear factor kappa-B (RANK)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a532a13e989d599fe8112364e78b86b
https://europepmc.org/articles/PMC6615562/

Oxytocin Modulates Nociception as an Agonist of Pain-Sensing TRPV1

Autor: Lusine Demirkhanyan, Sebastian Brauchi, Ricardo Kusuda, Xiaohui Sun, Deny Cabezas-Bratesco, Eleonora Zakharian, Victoria Oakes, Krishna Kumar Veeravalli, Alejandro Cohen, Bharath Chelluboina, Katharina Zimmermann, Tyler Dawson, Carmen Domene, Chike Cao, Yelena Nersesyan

Publikováno v: Nersesyan, Y, Demirkhanyan, L, Cabezas-Bratesco, D, Oakes, V, Kusuda, R, Dawson, T, Sun, X, Cao, C, Cohen, A M, Chelluboina, B, Veeravalli, K K, Zimmermann, K, Domene, C, Brauchi, S & Zakharian, E 2017, ' Oxytocin Modulates Nociception as an Agonist of Pain-Sensing TRPV1 ', Cell Reports, vol. 21, no. 6, pp. 1681-1691 . https://doi.org/10.1016/j.celrep.2017.10.063
Cell Reports, Vol 21, Iss 6, Pp 1681-1691 (2017)

Summary: Oxytocin is a hormone with various actions. Oxytocin-containing parvocellular neurons project to the brainstem and spinal cord. Oxytocin release from these neurons suppresses nociception of inflammatory pain, the molecular mechanism of which

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8888771c37431f4a6bc295e9d9fd8860
https://kclpure.kcl.ac.uk/ws/files/81600885/Oxytocin_Modulates_Nociception_as_NERSESYAN_Published7November2017_GOLD_VoR_CC_BY_NC_ND_.pdf