Zobrazeno 1 - 10
of 83
pro vyhledávání: '"Chikara Dohno"'
Autor:
Sanjukta Mukherjee, Asako Murata, Ryoga Ishida, Ayako Sugai, Chikara Dohno, Michiaki Hamada, Sudhir Krishna, Kazuhiko Nakatani
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 27, Iss , Pp 165-174 (2022)
Selective targeting of biologically relevant RNAs with small molecules is a long-standing challenge due to the lack of clear understanding of the binding RNA motifs for small molecules. The standard SELEX procedure allows the identification of specif
Externí odkaz:
https://doaj.org/article/4395786fe8e84c3e961dcc08eaac9c5a
Autor:
Yu, Mikame, Yui, Sakai, Ryo, Tahara, Kinuka, Doi, Tsuyoshi, Yamamoto, Chikara, Dohno, Takayuki, Shibata, Asako, Yamayoshi
Publikováno v:
Chemical and Pharmaceutical Bulletin. 70:726-730
Several psoralen-conjugated oligonucleotides (Ps-Oligos) have been developed as photo-crosslinkable oligonucleotides targeting DNA or RNA. To avoid potential off-target effects, it is important to investigate the selective photo-crosslinking reactivi
Autor:
Juki Nakao, Yu Mikame, Honoka Eshima, Tsuyoshi Yamamoto, Chikara Dohno, Takehiko Wada, Asako Yamayoshi
Publikováno v:
ChemBioChem.
Autor:
Tomonori Shibata, Chikara Dohno, Yuta Hishinuma, Kaoru Saito, Masaki Hagihara, Kazuhiko Nakatani, Kazuhiro Sugimoto, Yuri Sohma
Publikováno v:
Chemistry Letters. 50:1848-1851
We demonstrate here that DNA-binding small molecules stabilize hairpin structures formed in short tandem repeat sequences, leading to efficient contractions of repeats during in vitro DNA synthesis...
Autor:
Chikara Dohno, Daria Niewiadomska, Anna Baud, Katarzyna Taylor, Krzysztof Sobczak, Patryk Konieczny, Agnieszka Walczak, Ewa Stepniak-Konieczna, Sanjukta Mukherjee, Agnieszka Piasecka, Kazuhiko Nakatani
Publikováno v:
Nucleic Acids Research
Fragile X-associated tremor/ataxia syndrome (FXTAS) is a late-onset neurodegenerative disorder caused by a limited expansion of CGG repeats in the FMR1 gene. Degeneration of neurons in FXTAS cell models can be triggered by accumulation of polyglycine
Autor:
Nursakinah Mohd Zaifuddin, Mizuki Nihei, Masaki Hagihara, Chikara Dohno, Kaoru Saito, Kazuhiko Nakatani
Publikováno v:
Chemical Communications. 57:3235-3238
We demonstrated that a synthetic ligand NA, which selectively binds to a 5′-CAG-3′/5′-CAG-3′ triad, induced repeat contractions during DNA polymerase-mediated primer extension through the CAG repeat template. A thorough capillary electrophore
Publikováno v:
Nucleic acids research. 50(9)
The −1 programmed ribosomal frameshifting (−1 PRF) has been explored as a gene regulatory circuit for synthetic biology applications. The −1 PRF usually uses an RNA pseudoknot structure as the frameshifting stimulator. Finding a ligand-responsi
Autor:
Kazuhiko Nakatani, Jun Matsumoto, Tatsumasa Okamoto, Asako Murata, Chikara Dohno, Masayuki Nakamori
Publikováno v:
Chemistry (Weinheim an Der Bergstrasse, Germany)
Expanded CUG repeat RNA in the dystrophia myotonia protein kinase (DMPK) gene causes myotonic dystrophy type 1 (DM1) and sequesters RNA processing proteins, such as the splicing factor muscleblind‐like 1 protein (MBNL1). Sequestration of splicing f
Publikováno v:
Chemical Communications. 56:754-757
We have designed and synthesized a novel naphthyridine tetramer, p-NCTB, for the recognition of tandem guanine-guanine (G-G) mismatches in DNA. p-NCTB possesses a p-biphenyl linker connecting two naphthyridine carbamate dimer (NCD) moieties that reco
Autor:
Nadja A. Simeth, Chikara Dohno, Kazuhiko Nakatani, Shotaro Kobayashi, Wiktor Szymanski, Ben L. Feringa, Piermichele Kobauri, Stefano Crespi
Publikováno v:
Chemical Science, 12(26), 9207-9220. ROYAL SOC CHEMISTRY
Chemical Science
Chemical Science
Short, complementary DNA single strands with mismatched base pairs cannot undergo spontaneous formation of duplex DNA (dsDNA). Mismatch binding ligands (MBLs) can compensate this effect, inducing the formation of the double helix and thereby acting a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::568e5c2e593f5e256ecfc9157696f98f
https://research.rug.nl/en/publications/39f9f43d-cd29-4253-a918-8ec3f9ee9a66
https://research.rug.nl/en/publications/39f9f43d-cd29-4253-a918-8ec3f9ee9a66