Mumefural prevents insulin resistance and amyloid-beta accumulation in the brain by improving lowered interstitial fluid pH in type 2 diabetes mellitus

Autor: Shigekuni Hosogi, Atsukazu KUWAHARA, Yuko KUWAHARA, Saori TANAKA, Chikao SHIMAMOTO, Noriko TAGAWA, Ikuo KATO, Kanji YOSHIMOTO, Wataru AOI, Kazuyuki TAKATA, Hiroaki MIYAZAKI, Naomi NIISATO, Yasuhiro TSUBO, Katsumi YAGI, Takashi NAKAHARI, Yoshinori MARUNAKA

Publikováno v: Biomedical Research. 44:17-29

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::067e27bdebe8e7857a65904595e3c88b
https://doi.org/10.2220/biomedres.44.17

Measurement of [Cl−]i unaffected by the cell volume change using MQAE-based two-photon microscopy in airway ciliary cells of mice

Autor: Takashi Nakahari, Shigekuni Hosogi, Toshio Inui, Yoshinori Marunaka, Chikao Shimamoto, Saori Tanaka, Yukiko Ikeuchi, Haruka Kogiso

Publikováno v: The Journal of Physiological Sciences. 68:191-199

MQAE is a ‘non-ratiometric’ chloride ion (Cl−)-quenched fluorescent indicator that is used to determine intracellular Cl− concentration ([Cl−]i). MQAE-based two-photon microscopy is reported to be a useful method to measure [Cl−]i, but it

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::121a3084308550c13cddbbe073b411e1
https://doi.org/10.1007/s12576-018-0591-y

Retrospective Analysis of the Risk Factors for Grade IV Neutropenia in Oesophageal Cancer Patients Treated with a Docetaxel, Cisplatin, and 5-Fluorouracil Regimen

Autor: Chikao Shimamoto, Tomoya Yamamoto, Masahito Naito, Yoshihiro Miwa

Publikováno v: Chemotherapy. 62:215-224

Background: Previous Japanese trials of the docetaxel, cisplatin, and 5-fluorouracil regimen for oesophageal cancer have demonstrated that a large proportion of patients also develop grade IV neutropenia. Our aim was to examine the risk factors for n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0835110ebbdfe2b1352396ac15044f7e
https://doi.org/10.1159/000464273

Seihai-to (TJ-90)-Induced Activation of Airway Ciliary Beatings of Mice: Ca2+ Modulation of cAMP-Stimulated Ciliary Beatings via PDE1

Autor: Shigekuni Hosogi, Takashi Nakahari, Chikao Shimamoto, Masako Sumiya, Saori Tanaka, Yukiko Ikeuchi, Haruka Kogiso, Yoshinori Marunaka, Toshio Inui

Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences; Volume 19; Issue 3; Pages: 658
International Journal of Molecular Sciences, Vol 19, Iss 3, p 658 (2018)

Sei-hai-to (TJ-90, Qing Fei Tang), a Chinese traditional medicine, increases ciliary beat frequency (CBF) and ciliary bend angle (CBA) mediated via cAMP (3′,5′-cyclic adenosine monophosphate) accumulation modulated by Ca2+-activated phosphodieste

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d564fd04797b76dbed1496f598a5039b
http://europepmc.org/articles/PMC5877519

Disinfection potential of electrolyzed strongly acidic water against Mycobacteria: Conditions of disinfection and recovery of disinfection potential by reelectrolysis

Autor: Hideki Hayashi, Hong Wu, Takashi Nakano, Kouichi Sano, Chikao Shimamoto

Publikováno v: Biomedical Research. 36:109-113

We attempted to clarify in detail the conditions of disinfection using electrolyzed strongly acidic water (ESW) against Mycobacteria, and the recovery of the disinfection potential of inactivated ESW by re-electrolysis. We mixed ESW containing 10, 20

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0bc9bbe40b88bf4279074f0fc67fd6ea
https://doi.org/10.2220/biomedres.36.109